PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Extracts and isolated neolignans demonstrate significant anti-inflammatory activity in vitro by inhibiting NO production and key inflammatory enzymes [PMID:12576203, PMID:38623908, PMID:19900811].
Piper kadsura extract and components (Hancinone, Futoquinol) improved cell viability, restored glycolysis, and reduced neuronal damage in Aβ25-35-induced mouse models and cell lines [PMID:40576700, PMID:38330236, PMID:35933005].
Galgravin isolated from P. kadsura ameliorated LPS-induced endotoxemia in mice by suppressing proinflammatory cytokines in the lungs and serum [PMID:38068895].
Extracts protected human SW1353 cells against H2O2-induced apoptosis by upregulating antioxidant enzymes (SOD-2, GPx, CAT) [PMID:34684868].
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 16724856 (2006) — Anti-inflammatory neolignans from Piper kadsura. · Journal of natural products
- 2.PMID: 40576700 (2025) — Piper Kadsura Extract and its Bioactive Components Attenuates Aβ25-35-Induced Neurotoxicity by Modulating Glycolysis and Activating the SIRT1/PPARγ/GLUT1 Axis. · Neurochemical research
- 3.PMID: 40424233 (2025) — Hancinone possesses potentials on increasing the ability of HMC3 cells to phagocytosis of Aβ1-42 via TREM2/Syk/PI3K/AKT/mTOR signaling pathway. · PloS one
- 4.PMID: 26260180 (2016) — The complete plastid genome of Piper kadsura (Piperaceae), an East Asian woody vine. · Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis
- 5.PMID: 38068895 (2023)