PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Ingestion of sun-dried Nelumbo nucifera leaf extract significantly decreased whole body fat in both men and women; men also showed significant reductions in visceral fat and waist circumference [PMID:34852695].
Extracts inhibited neutral fat accumulation in mice and suppressed adipogenesis in 3T3-L1 preadipocytes [PMID:34462872, 36297031].
Lotus leaf flavonoids inhibited proliferation and induced apoptosis in human lung cancer A549 and H446 cells [PMID:33653412]; leaf extract showed concentration-dependent cytotoxicity against osteosarcoma Saos-2 cells [PMID:38021731].
Nuciferine alleviated steatosis and insulin resistance in NAFLD mice [PMID:35755273].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 33653412 (2021) — Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS/p38 MAPK pathway. · Biological research
- 2.PMID: 35755273 (2022) — Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway. · Acta pharmaceutica Sinica. B
- 3.PMID: 35770727 (2022) — Research Advances in Lotus Leaf as Chinese Dietary Herbal Medicine. · The American journal of Chinese medicine
- 4.PMID: 38021731 (2023) — Nelumbo nucifera Leaf Extract Induces Cytotoxicity in Osteosarcoma Saos-2 Cells. · Cureus
- 5.PMID: 34852695 (2022) — Fat reducing effects of Nelumbo nucifera leaf extract in overweight patients.