PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Subcritical water extract of C. japonicum significantly down-regulated pro-inflammatory molecules (nitrite, PGE2, IL-6, IL-8, TNF-α), decreased permeability, and increased expression of tight junction proteins (ZO-1, occludin, claudin-1) in a Caco-2 and RAW264.7 co-culture model [PMID:31276135].
An ethyl acetate extract of C. japonicum leaves (CJL3) exhibited anti-inflammatory effects on lipopolysaccharide (LPS)-activated Kupffer cells [PMID:37895873].
Ethyl acetate extracts of C. japonicum branches (CJB3) suppressed oxidative stress and ROS production in LPS-activated cells [PMID:36838961].
Evidence summary
PubMed sources
- 1.PMID: 37895873 (2023) — Anti-Inflammatory Effect of Cinnamomum japonicum Siebold's Leaf through the Inhibition of p38/JNK/AP-1 Signaling. · Pharmaceuticals (Basel, Switzerland)
- 2.PMID: 36838961 (2023) — Cinnamomum japonicum Siebold Branch Extracts Attenuate NO and ROS Production via the Inhibition of p38 and JNK Phosphorylation. · Molecules (Basel, Switzerland)
- 3.PMID: 31276135 (2019) — Cinnamon subcritical water extract attenuates intestinal inflammation and enhances intestinal tight junction in a Caco-2 and RAW264.7 co-culture model. · Food & function