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Trigonella foenum-graecum
Fenugreek is an annual leguminous plant used in traditional medicine across India, the Middle East, and North Africa. Its seeds are particularly valued for blood sugar regulation, digestive support, and lactation promotion. It contains a unique amino acid, 4-hydroxyisoleucine, that has direct insulin-sensitizing effects.
| Drug | Severity | Description |
|---|---|---|
| Insulin | moderate | Fenugreek may enhance the blood sugar-lowering effect of insulin, increasing hypoglycemia risk. |
| Warfarin (Coumadin) | moderate | Fenugreek contains coumarin compounds that may enhance warfarin's anticoagulant effect. |
| Glipizide | moderate | Fenugreek may enhance blood sugar-lowering effects of sulfonylureas, increasing hypoglycemia risk. |