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Piper methysticum
Kava is a plant native to the Pacific Islands where it has been consumed ceremonially for over 3,000 years. It is widely used for its anxiolytic and relaxant properties, and clinical evidence supports its effectiveness for generalized anxiety. Concerns about liver toxicity led to bans in some countries, though quality-controlled products appear safe.
| Drug | Severity | Description |
|---|---|---|
| Alprazolam (Xanax) | severe | Kava combined with benzodiazepines may cause excessive sedation, coma, or respiratory depression. A case of coma has been reported with this combination. |
| Levodopa | severe | Kava may reduce the effectiveness of levodopa, worsening Parkinsonian symptoms. Case reports document worsening of symptoms. |
| Acetaminophen (Tylenol) | severe | Kava combined with acetaminophen may increase risk of liver damage, as both are hepatotoxic. |
| Alcohol | severe | Combining kava with alcohol significantly increases the risk of liver damage and excessive CNS depression. |