Question 1

How does DGL licorice work for stomach ulcers?

Accepted Answer

DGL (deglycyrrhizinated licorice) works by stimulating mucus production and enhancing mucosal defense in the gastrointestinal tract. Its active flavonoids, including isoliquiritigenin and liquiritigenin, increase prostaglandin synthesis and promote epithelial cell proliferation, coating and protecting the stomach lining. Unlike regular licorice, DGL has glycyrrhizin removed, eliminating mineralocorticoid effects while retaining gastroprotective properties. Evidence Level B supports its use for gastric mucosal protection.

Question 2

Does DGL licorice interact with any medications?

Accepted Answer

DGL licorice has minimal drug interactions compared to standard licorice because glycyrrhizin—the compound responsible for most interactions—has been removed. However, DGL may still interact with anticoagulants and antiplatelet medications due to its flavonoid content. Patients taking warfarin, aspirin, or other blood thinners should consult a healthcare provider before use. DGL does not typically cause potassium depletion or blood pressure changes associated with regular licorice root.

Question 3

What is the recommended dosage for DGL licorice?

Accepted Answer

The standard adult dosage for DGL licorice is 380-400mg of chewable tablets taken before meals, typically two to three times daily. Chewable forms are preferred because mixing with saliva activates the mucilaginous compounds that coat and protect the gastric mucosa. For peptic ulcers and GERD symptoms, this dosage has demonstrated efficacy in clinical studies. Evidence Level B supports this dosing regimen for gastrointestinal applications.

Question 4

Is DGL licorice safe to take during pregnancy?

Accepted Answer

DGL licorice is considered unsafe during pregnancy despite the removal of glycyrrhizin. While DGL lacks the mineralocorticoid effects of standard licorice, insufficient safety data exists for pregnant women. Traditional use and animal studies suggest potential uterine stimulation and hormonal effects from licorice compounds. Pregnant and breastfeeding women should avoid DGL supplementation and consult a healthcare provider before using any herbal products.

Question 5

What is DGL licorice used for?

Accepted Answer

DGL (deglycyrrhizinated licorice) is primarily used for gastrointestinal conditions including peptic ulcers, gastric mucosal protection, gastroesophageal reflux disease (GERD), and aphthous ulcers (canker sores). Unlike standard licorice, DGL provides GI benefits without hormonal side effects because glycyrrhizin has been removed. The flavonoids and compounds like glabridin promote healing of the digestive tract lining. Evidence Level B supports its therapeutic use for these gastrointestinal applications.

Licorice DGL

Sources & Citations

Fennel

Meadowsweet

Marshmallow Leaf

Summary

Background

Traditional uses

Active compounds

Mechanism of action

Clinical evidence

Safety & adverse effects

Pregnancy & lactation

Evidence summary

PubMed sources

Government sources