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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Leonurus cardiaca is a perennial herb used traditionally for nervous heart conditions, digestive disorders, and gynecological afflictions [PMID:23042598, PMID:31119169].
Background
Leonurus cardiaca is a perennial plant indigenous to central Europe and Scandinavia, also found in temperate Russia, central Asia, and North America [PMID:23042598]. The herb consists of aerial parts gathered during the flowering period [PMID:23042598].
Traditional uses
Traditionally used internally for nervous heart conditions, digestive disorders, bronchial asthma, climacteric symptoms, and amenorrhoea, and externally for wounds [PMID:23042598]. It has also been used as a cardiotonic and for treating dysmenorrhea, menopausal anxiety, and postpartum depression [PMID:31119169].
Active compounds
Identified compounds include flavonoids (such as hyperoside, catechin, and rutin), phenolic acids (chlorogenic, caffeic, and rosmarinic acids), ellagic acid, monoterpenes, diterpenes, triterpenes, nitrogen-containing compounds, phenylpropanoids, volatile oils, sterols, tannins, and polysaccharides [PMID:23042598, PMID:33503956, PMID:39472158, PMID:42279633]. Stachydrine is also found in L. cardiaca [PMID:23923634].
Clinical evidence
Evidence APostpartum hemorrhage (PPH) prevention
Motherwort injection, alone or combined with oxytocin, is used to prevent PPH after vaginal delivery, cesarean section, and induced abortion [PMID:29882344, PMID:31354850, PMID:35935833, PMID:40527062].
Evidence APost-partum blood loss
Add-on therapy of motherwort injection to carboprost tromethamine significantly reduced post-partum blood loss at 2h and 24h [PMID:30288846].
Evidence DBlood hyperviscosity
Intravenous administration of motherwort (Leonurus Heterophyllus Sweet) showed improvement in hemorheology, decreasing blood viscosity and fibrinogen volume [PMID:2589238].
Safety & adverse effects
In a case report of hepatitis, motherwort was part of a herbal remedy containing mistletoe; however, mistletoe was identified as the probable cause of the illness [PMID:6779941].
Pregnancy & lactation
Motherwort injection is used in clinical practice for the prevention of uterine hemorrhage during and after delivery and abortion [PMID:29882344, PMID:35935833, PMID:40527062].
Evidence summary
Strong evidence (Meta-analyses/SRs) exists for the use of motherwort injections in preventing postpartum hemorrhage, primarily based on L. japonicus. Evidence for L. cardiaca specifically is largely based on traditional use and phytochemical reviews.
PubMed sources
1.PMID: 23042598 (2013) — Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. · Phytotherapy research : PTR
2.PMID: 40527062 (2025) — Motherwort synergized with oxytocin for postpartum hemorrhage prevention: Integrated clinical efficacy and mechanism exploration. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 33503956 (2021) — Phytochemical and Psychotropic Research of Motherwort (Leonurus cardiaca L.) Modified Dry Extracts. · Plants (Basel, Switzerland)
4.PMID: 35935833 (2022) — Motherwort Injection for Preventing Uterine Hemorrhage in Women With Induced Abortion: A Systematic Review and Meta-Analysis of Randomized Evidence. · Frontiers in pharmacology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Motherwort injection for preventing postpartum hemorrhage in pregnant women with cesarean section: A systematic review and meta-analysis.
· Journal of evidence-based medicine
6.PMID: 31119169 (2019) — Leonurus cardiaca L. as a Source of Bioactive Compounds: An Update of the European Medicines Agency Assessment Report (2010). · BioMed research international
7.PMID: 42279633 (2026) — Water Infusions of Motherwort (Leonurus cardiaca) as a Source of Chlorogenic Acid and Antioxidant Properties. · Foods (Basel, Switzerland)
8.PMID: 39472158 (2024) — Stable Leonurus cardiaca L. polysaccharide-stabilized palladium nanoparticles for sensitive colorimetric detection of acetylcholine. · International journal of biological macromolecules
9.PMID: 30288846 (2019) — Efficacy and safety of motherwort injection add-on therapy to carboprost tromethamine for prevention of post-partum blood loss: A meta-analysis of randomized controlled trials. · The journal of obstetrics and gynaecology research
10.PMID: 31354850 (2019) — Motherwort Injection for Preventing Postpartum Hemorrhage in Women with Vaginal Delivery: A Systematic Review and Meta-Analysis of Randomized Evidence. · Evidence-based complementary and alternative medicine : eCAM
11.PMID: 6779941 (1981) — Mistletoe hepatitis. · British medical journal (Clinical research ed.)
12.PMID: 2589238 (1989) — Effect of motherwort on blood hyperviscosity. · The American journal of Chinese medicine
13.PMID: 23923634 (2013) — Stachydrine in Leonurus cardiaca, Leonurus japonicus, Leonotis leonurus: detection and quantification by instrumental HPTLC and 1H-qNMR analyses. · Die Pharmazie