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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Nopal (Opuntia ficus-indica) is a cactus known for its nutritional value and bioactive compounds that exhibit antioxidant, anti-inflammatory, and metabolic benefits [PMID:35921318, PMID:25232708].
Background
Opuntia ficus-indica, commonly known as nopal or prickly pear, is a dicotyledonous angiosperm of the Cactaceae family [PMID:25232708, PMID:36771630]. It is highly adapted to arid and semi-arid climates in tropical and subtropical regions and is cultivated globally, particularly in Mexico, Africa, the Middle East, and India [PMID:25232708, PMID:35927821, PMID:37631119].
Traditional uses
Nopal has been used in traditional medicine for conditions including diabetes, acne, arthrosis, dermatosis, diarrhea, fever, high blood pressure, prostatitis, rheumatism, stomachache, tumors, warts, allergies, wounds, and colitis [PMID:35927821]. It is also traditionally used for its medicinal properties in Mexico [PMID:37233362].
Active compounds
Bioactive components include betalains (such as betanin), polyphenols, flavonoids, tannins, phenolic acids, carotenoids, ascorbate, biopeptides, soluble and insoluble fibers, vitamins, polyunsaturated fatty acids, and amino acids [PMID:35921318, PMID:37631119, PMID:25232708, PMID:35927821, PMID:37860248].
Mechanism of action
Nopal may influence glucose metabolism by improving insulin sensitivity, reducing insulin resistance, and modulating gut microbiota [PMID:37994760]. Its beneficial effects are associated with the attenuation of oxidative stress and inflammation markers [PMID:38732528, PMID:37371904].
Clinical evidence
Evidence BIrritable Bowel Syndrome (IBS)
Nopal fiber powder (10, 20, or 30 g/day) improved symptoms in the short term compared to placebo [PMID:32935904].
Evidence CHyperglycemia/Diabetes
Consumption of prickly pear cladodes is reported to exert hypoglycemic effects [PMID:35208623]; it is the most commonly used herbal hypoglycemic among persons of Mexican descent [PMID:11926665].
Evidence CObesity and Metabolic Syndrome
Preclinical studies show a significant capacity to prevent obesity and related co-morbidities, though clinical studies have shown mixed results [PMID:38732528].
Evidence DHepatic Steatosis
In obese Zucker rats, a diet containing 4% nopal reduced hepatic triglycerides by approximately 50% and reduced biomarkers of hepatocyte injury [PMID:23014486].
Safety & adverse effects
Embedded prickly pear spines (glochids) can cause local and systemic inflammatory conditions, allergic contact dermatitis, and ocular keratoconjunctivitis [PMID:41941578, PMID:24669148]. The plant also has high potential as an invasive species [PMID:37631119].
Evidence summary
Evidence is primarily based on reviews and preclinical animal models (Level C and D), with one randomized controlled trial (Level B) supporting its use for IBS symptoms.
PubMed sources
1.PMID: 35921318 (2023) — Betalains: colours for human health. · Natural product research
2.PMID: 37631119 (2023) — Adapting to Climate Change with Opuntia. · Plants (Basel, Switzerland)
3.PMID: 36771630 (2023) — Opuntia ficus-indica Fruit: A Systematic Review of Its Phytochemicals and Pharmacological Activities. · Plants (Basel, Switzerland)
4.PMID: 24669148 (2014) — Prickly pear spine keratoconjunctivitis. · Middle East African journal of ophthalmology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
PMID: 36501373 (2022) — Challenges Inherent in Controlling Prickly Pear Species; a Global Review of the Properties of Opuntia stricta, Opuntia ficus-indica and Opuntia monacantha. · Plants (Basel, Switzerland)
7.PMID: 25232708 (2014) — Nopal cactus (Opuntia ficus-indica) as a source of bioactive compounds for nutrition, health and disease. · Molecules (Basel, Switzerland)
8.PMID: 33670110 (2021) — Opuntia ficus-indica (L.) Mill.: A Multi-Benefit Potential to Be Exploited. · Molecules (Basel, Switzerland)
9.PMID: 35927821 (2022) — Opuntia ficus indica (L.) Mill. An Ancient Plant Source of Nutraceuticals. · Current topics in medicinal chemistry
10.PMID: 37371904 (2023) — Beneficial Effects of Opuntia spp. on Liver Health. · Antioxidants (Basel, Switzerland)
11.PMID: 37860248 (2023) — Opuntia ficus-indica (L.) Mill. - anticancer properties and phytochemicals: current trends and future perspectives. · Frontiers in plant science
12.PMID: 11926665 (2002) — Natural products used for diabetes. · Journal of the American Pharmaceutical Association (Washington, D.C. : 1996)
13.PMID: 37233362 (2023) — Decellularized Scaffolds of Nopal (Opuntia Ficus-indica) for Bioengineering in Regenerative Dentistry. · Journal of functional biomaterials
14.PMID: 31604414 (2019) — Nopal (Opuntia spp.) and its Effects on Metabolic Syndrome: New Insights for the Use of a Millenary Plant. · Current pharmaceutical design
15.PMID: 30456012 (2018) — Prickly pear cactus cladodes powder of Opuntia ficus indica as a cost effective biosorbent for dyes removal from aqueous solutions. · 3 Biotech
16.PMID: 26476894 (2016) — Application of Opuntia ficus-indica in bioremediation of wastewaters. A critical review. · Journal of environmental management
17.PMID: 39684127 (2024) — Extraction of Purple Prickly Pear (Opuntia ficus-indica) Mucilage by Microfiltration, Composition, and Physicochemical Characteristics. · Polymers
18.PMID: 34443606 (2021) — Prickly Pear Seed Oil Extraction, Chemical Characterization and Potential Health Benefits. · Molecules (Basel, Switzerland)
19.PMID: 38732528 (2024) — Usefulness of Opuntia spp. on the Management of Obesity and Its Metabolic Co-Morbidities. · Nutrients
20.PMID: 32935904 (2021) — Nopal fiber (Opuntia ficus-indica) improves symptoms in irritable bowel syndrome in the short term: a randomized controlled trial. · Neurogastroenterology and motility
21.PMID: 35208623 (2022) — Prickly Pear Cacti (Opuntia spp.) Cladodes as a Functional Ingredient for Hyperglycemia Management: A Brief Narrative Review. · Medicina (Kaunas, Lithuania)
22.PMID: 28805459 (2018) — Opuntia ficus-indica (L.) Miller as a source of bioactivity compounds for health and nutrition. · Natural product research
23.PMID: 37256773 (2023) — Developmental dynamics of crassulacean acid metabolism (CAM) in Opuntia ficus-indica. · Annals of botany
24.PMID: 25356040 (2014) — Review of natural products with hepatoprotective effects. · World journal of gastroenterology
25.PMID: 36233157 (2022) — Protective Effect of Nopal Cactus (Opuntia ficus-indica) Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver. · International journal of molecular sciences
26.PMID: 39286769 (2024) — Phytochemical, biological, and nutritional properties of the prickly pear, Opuntia dillenii: A review. · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
27.PMID: 37994760 (2023) — Unraveling the Role of Prickly Pear Extract as a Potent Nutraceutical Agent Against Metabolic Syndromes. · La Clinica terapeutica
29.PMID: 37050137 (2023) — Physicochemical, Nutritional, and Medicinal Properties of Opuntia ficus-indica (L.) Mill. and Its Main Agro-Industrial Use: A Review. · Plants (Basel, Switzerland)
30.PMID: 23014486 (2012) — Opuntia ficus indica (nopal) attenuates hepatic steatosis and oxidative stress in obese Zucker (fa/fa) rats. · The Journal of nutrition