PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Systematic review of RCTs identified Poria cocos as one of the most frequently used herbs associated with positive cognitive enhancing outcomes [PMID:22303969].
Polysaccharidum of Poria cocos oral solution was approved by the Chinese FDA for treating multiple types of cancers [PMID:30444050].
Water-soluble and carboxymethylated polysaccharides reduced serum BUN, creatinine, and inflammatory factors in mouse models [PMID:40774496, PMID:40216133].
Ethanol extracts and exosome-like nanovesicles reduced lipid accumulation and liver injury in rat and mouse models [PMID:36278226, PMID:40076875].
PCP enhanced cognitive function and mitigated pathological alterations in 3xTg-AD mice [PMID:40254847].
Evidence summary
PubMed sources
- 1.PMID: 39482471 (2025) — Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology. · Acta pharmacologica Sinica
- 2.PMID: 37517750 (2023) — Poria cocos polysaccharide improves intestinal barrier function and maintains intestinal homeostasis in mice. · International journal of biological macromolecules
- 3.PMID: 36674937 (2023) — Poria cocos Polysaccharide Ameliorated Antibiotic-Associated Diarrhea in Mice via Regulating the Homeostasis of the Gut Microbiota and Intestinal Mucosal Barrier. · International journal of molecular sciences
- 4.PMID: 40076875 (2025) — Poria cocos-Derived Exosome-like Nanovesicles Alleviate Metabolic Dysfunction-Associated Fatty Liver Disease by Promoting Mitophagy and Inhibiting NLRP3 Inflammasome Activation. · International journal of molecular sciences
- 5.PMID: 40484558