PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Dichloromethane extracts of T. sinensis pericarps showed therapeutic effects in mice models of DKD [PMID:41831743]. n-butanol seed extracts demonstrated protective effects on the kidneys of diabetic nephropathy rats [PMID:27050993].
n-butanol soluble fractions of water extract from fruits reduced cerebral infarct and edema volume and attenuated neurological deficits in rats in a dose-dependent manner [PMID:24269248]. Fruit polyphenols demonstrated neuroprotective properties in MCAO/R rats [PMID:39828145].
Synthetic derivatives of natural compounds from T. sinensis (TRI-03) induced GSDME-mediated pyroptosis in melanoma cells by inhibiting TrxR1 and destabilizing XIAP [PMID:40486906].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 33164370 (2020) — [Terpenoids from Toona sinensis]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- 2.PMID: 41831743 (2026) — Identifying the active components and mechanisms of Toona sinensis pericarps for the treatment of diabetic kidney disease using network pharmacology and experimental verification. · Journal of ethnopharmacology
- 3.PMID: 27279719 (2016) — Quantitative Analysis and Comparison of Four Major Flavonol Glycosides in the Leaves of Toona sinensis (A. Juss.) Roemer (Chinese Toon) from Various Origins by High-Performance Liquid Chromatography-Diode Array Detector and Hierarchical Clustering Analysis. · Pharmacognosy magazine
- 4.PMID: 36292684 (2022) — Evolutionary Divergence between Toona ciliata and Toona sinensis Assayed with Their Whole Genome Sequences. · Genes
- 5.PMID: 38338461