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Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Berberine may increase dextromethorphan blood levels by inhibiting its metabolism.
Berberine inhibits CYP2D6, which is the primary enzyme responsible for dextromethorphan metabolism.
Source: Clinical Studies · Reviewed April 2026
Berberine + Dextromethorphan: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Berberine may increase dextromethorphan blood levels by inhibiting its metabolism.
Berberine inhibits CYP2D6, which is the primary enzyme responsible for dextromethorphan metabolism.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.