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Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Berberine may increase losartan levels and its active metabolite, potentially enhancing blood pressure effects.
Berberine inhibits CYP2C9 and CYP3A4 involved in losartan metabolism.
Source: Clinical Studies · Reviewed April 2026
Berberine + Losartan: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Berberine may increase losartan levels and its active metabolite, potentially enhancing blood pressure effects.
Berberine inhibits CYP2C9 and CYP3A4 involved in losartan metabolism.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.