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Actaea racemosa
Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Black cohosh has been associated with rare cases of liver damage. Combining with other hepatotoxic drugs may increase liver injury risk.
Potential additive hepatotoxicity when combined with drugs that stress liver function.
Source: Natural Medicines Database · Reviewed April 2026
Black Cohosh + Hepatotoxic medications (general): use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Black cohosh has been associated with rare cases of liver damage. Combining with other hepatotoxic drugs may increase liver injury risk.
Potential additive hepatotoxicity when combined with drugs that stress liver function.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.