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Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Feverfew (parthenolide) inhibits platelet aggregation and serotonin release from platelets, adding to aspirin's effect and increasing bleeding risk.
Parthenolide blocks platelet aggregation and granule secretion through mechanisms distinct from aspirin's COX inhibition, producing an additive effect.
Source: Natural Medicines Database · Reviewed September 2026
Feverfew + Aspirin: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Feverfew (parthenolide) inhibits platelet aggregation and serotonin release from platelets, adding to aspirin's effect and increasing bleeding risk.
Parthenolide blocks platelet aggregation and granule secretion through mechanisms distinct from aspirin's COX inhibition, producing an additive effect.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.