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Moderate· moderate-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Feverfew may increase bleeding risk when combined with warfarin due to antiplatelet effects.
Parthenolide inhibits platelet aggregation and may affect prostaglandin synthesis, adding to warfarin's anticoagulant activity.
Source: Natural Medicines Database · Reviewed April 2026
Feverfew + Warfarin (Coumadin): use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Feverfew may increase bleeding risk when combined with warfarin due to antiplatelet effects.
Parthenolide inhibits platelet aggregation and may affect prostaglandin synthesis, adding to warfarin's anticoagulant activity.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.