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Severe· well-documented
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Kava combined with benzodiazepines may cause excessive sedation, coma, or respiratory depression. A case of coma has been reported with this combination.
Kava kavapyrones enhance GABAergic activity, producing additive CNS depression with benzodiazepines.
Source: Clinical Studies · Reviewed April 2026
Kava + Alprazolam (Xanax): high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Kava combined with benzodiazepines may cause excessive sedation, coma, or respiratory depression. A case of coma has been reported with this combination.
Kava kavapyrones enhance GABAergic activity, producing additive CNS depression with benzodiazepines.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.