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Severe· moderate-evidence
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Concurrent use of valerian and alprazolam may lead to excessive sedation and respiratory depression.
Additive GABA-A receptor modulation causing enhanced CNS depression.
Source: Natural Medicines Database · Reviewed April 2026
Valerian + Alprazolam (Xanax): high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Concurrent use of valerian and alprazolam may lead to excessive sedation and respiratory depression.
Additive GABA-A receptor modulation causing enhanced CNS depression.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.