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Severe· well-documented
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Combining valerian with lorazepam increases risk of excessive sedation and CNS depression.
Additive GABAergic effects enhance CNS depression.
Source: Natural Medicines Database · Reviewed April 2026
Valerian + Lorazepam (Ativan): high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Combining valerian with lorazepam increases risk of excessive sedation and CNS depression.
Additive GABAergic effects enhance CNS depression.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.