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Severe· well-documented
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Valerian may enhance the sedative effects of benzodiazepines, causing excessive drowsiness, respiratory depression, and impaired motor function.
Valerian acts on GABA receptors similarly to benzodiazepines, creating additive central nervous system depression.
Source: Natural Medicines Database · Reviewed April 2026
Valerian + Diazepam (Valium): high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Valerian may enhance the sedative effects of benzodiazepines, causing excessive drowsiness, respiratory depression, and impaired motor function.
Valerian acts on GABA receptors similarly to benzodiazepines, creating additive central nervous system depression.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.