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Mild· limited-evidence
Low risk at usual doses, but report any unusual symptoms to a healthcare professional.
Milk thistle may slow the metabolism of diazepam, potentially increasing its sedative effects.
Silymarin inhibits CYP3A4 and CYP2C19, which are involved in diazepam metabolism.
Source: Clinical Studies · Reviewed April 2026
Milk Thistle + Diazepam (Valium): low risk. Low risk at usual doses, but report any unusual symptoms to a healthcare professional. Milk thistle may slow the metabolism of diazepam, potentially increasing its sedative effects.
Silymarin inhibits CYP3A4 and CYP2C19, which are involved in diazepam metabolism.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.