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Mild· limited-evidence
Low risk at usual doses, but report any unusual symptoms to a healthcare professional.
Milk thistle may slightly increase simvastatin levels through enzyme inhibition.
Silymarin may inhibit CYP3A4 and OATP1B1 transporters involved in statin metabolism and uptake.
Source: Clinical Studies · Reviewed April 2026
Milk Thistle + Simvastatin: low risk. Low risk at usual doses, but report any unusual symptoms to a healthcare professional. Milk thistle may slightly increase simvastatin levels through enzyme inhibition.
Silymarin may inhibit CYP3A4 and OATP1B1 transporters involved in statin metabolism and uptake.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.