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Hypericum perforatum
Severe· well-documented
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
St. John's Wort reduces simvastatin levels by approximately 50%, significantly diminishing its cholesterol-lowering effect.
CYP3A4 induction increases simvastatin metabolism.
Source: Clinical Studies · Reviewed April 2026
St. John's Wort + Simvastatin (Zocor): high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. St. John's Wort reduces simvastatin levels by approximately 50%, significantly diminishing its cholesterol-lowering effect.
CYP3A4 induction increases simvastatin metabolism.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.