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Moderate· limited-evidence
May be possible under supervision — talk to your prescriber or pharmacist before combining.
Peppermint oil may increase cyclosporine absorption and blood levels.
Menthol may inhibit CYP3A4 and P-glycoprotein in the intestine, increasing cyclosporine bioavailability.
Source: Clinical Studies · Reviewed April 2026
Peppermint + Cyclosporine: use caution. May be possible under supervision — talk to your prescriber or pharmacist before combining. Peppermint oil may increase cyclosporine absorption and blood levels.
Menthol may inhibit CYP3A4 and P-glycoprotein in the intestine, increasing cyclosporine bioavailability.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.