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Severe· well-documented
Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring.
Goldenseal (berberine) may significantly increase cyclosporine blood levels, increasing toxicity risk.
Berberine in goldenseal inhibits CYP3A4 and P-glycoprotein, reducing cyclosporine metabolism.
Source: Clinical Studies · Reviewed April 2026
Goldenseal + Cyclosporine: high risk. Avoid this combination unless your prescriber explicitly approves it with appropriate monitoring. Goldenseal (berberine) may significantly increase cyclosporine blood levels, increasing toxicity risk.
Berberine in goldenseal inhibits CYP3A4 and P-glycoprotein, reducing cyclosporine metabolism.
Do not stop either abruptly on your own. Talk to your prescriber or pharmacist promptly — bring this page to your appointment.
Educational information only — not medical advice. Always verify with a healthcare professional.