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Hydrastis canadensis
Goldenseal is a perennial herb native to North America, traditionally used by Native Americans for infections and digestive complaints. It contains berberine and hydrastine as primary active compounds. Due to overharvesting, it is now considered at risk in the wild, and cultivated sources are preferred.
| Drug | Severity | Description |
|---|---|---|
| Cyclosporine | severe | Goldenseal (berberine) may significantly increase cyclosporine blood levels, increasing toxicity risk. |
| Metformin | moderate | Berberine in goldenseal may enhance blood sugar-lowering effects of metformin. |