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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Aconite Root Processed (Aconitum carmichaelii), known as Fuzi or Chuanwu, is a traditional Asian medicinal herb used for cardiovascular and inflammatory conditions, though it contains potent alkaloids that can be toxic if not processed correctly [PMID:35240238, PMID:34315520].
Contexte
Aconitum carmichaelii Debx. is a herbaceous plant indigenous to China and used in traditional medicine across Asia, including Japan and Korea [PMID:35713121, PMID:35240238]. The two primary parts used in Traditional Chinese Medicine (TCM) are the lateral roots ('Fuzi') and mother roots ('Chuanwu') [PMID:35240238].
Usages traditionnels
Traditionally used to treat heart failure, acute myocardial infarction, rheumatoid arthritis, rheumatic fever, painful joints, endocrinal disorders, and as an analgesic [PMID:35405250, PMID:35240238, PMID:25479152].
Composés actifs
The plant contains C19-norditerpenoid alkaloids (aconitine, mesaconitine, hypaconitine) and C20-diterpene alkaloids (such as songorine) [PMID:35405250, PMID:33189984, PMID:22567575]. Other constituents include polysaccharides, phenolic compounds, flavonoids, and higenamine [PMID:35240238, PMID:36257343, PMID:35161335].
Mécanisme d'action
Cardiotonic effects are linked to the inhibition of myocardial fibrosis, apoptosis, and autophagy, and improvement of mitochondrial energy metabolism via the RAAS system, PI3K/AKT, JAK/STAT, and AMPK/mTOR signaling pathways [PMID:36324672]. Songorine specifically promotes cardiac mitochondrial biogenesis via Nrf2 induction and suppression of ROS [PMID:33189984]. Neuropharmacological actions involve modulation of ion transport and neurotransmitter synthesis [PMID:39527885].
Preuves cliniques
Preuve ARheumatoid Arthritis
Combination therapy of Aconitum and Western medicine showed improved efficacy and safety compared to Western medicine alone [PMID:29552837]
Preuve AAllergic Rhinitis
Ma-Huang-Fu-Zi-Xi-Xin decoction was evaluated for treatment effects and safety [PMID:29636787]
Preuve DHeart Failure/Myocardial Infarction
In rat models, aqueous extracts of brained aconite and water extraction of toasted Aconitum carmichaelii attenuated heart failure by inhibiting inflammation and abnormal vascular remodeling [PMID:36600948, PMID:36982912]
Preuve DCisplatin-induced Acute Kidney Injury
Total alkaloids of Aconitum carmichaelii alleviate injury by inhibiting inflammation and oxidative stress related to gut microbiota metabolism [PMID:39442279]
Sécurité et effets indésirables
Aconite is toxic; overdose or faulty processing can lead to aconite poisoning, characterized by fatal ventricular tachyarrhythmias and asystole [PMID:33551404, PMID:22469654, PMID:7839574]. Toxicity is primarily attributed to diester-diterpenoid alkaloids over-activating Na+ and Ca2+ ion channels and inducing mitochondrial apoptosis [PMID:36324672, PMID:39527885]. Tinctures are noted to be significantly more toxic than decoctions [PMID:22469654].
Posologie et administration
The Chinese Pharmacopeia regulates the safe clinical dosage of Fuzi at 3-15 g/person/day, though this lacks bench evidence and does not differentiate between processing types [PMID:36216199]. Consult a healthcare provider.
Synthèse des preuves
Evidence ranges from high-level meta-analyses for rheumatoid arthritis to preclinical animal models for cardiovascular and renal protection. Significant warnings exist regarding the high toxicity of unprocessed or improperly prepared forms.
Sources PubMed
1.PMID: 35405250 (2022) — Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification. · Journal of ethnopharmacology
2.PMID: 33189984 (2021) — Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis. · Redox biology
3.PMID: 36600948 (2022) — Cardioprotective Effects of Aconite in Isoproterenol-Induced Myocardial Infarction in Rats. · Oxidative medicine and cellular longevity
4.PMID: 33551404 (2022) — Adverse Effects of Kampo Medicines. · Internal medicine (Tokyo, Japan)
5.PMID: 35713121 (2022) — The clonal growth in Aconitum carmichaelii Debx. · Plant signaling & behavior
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 35240238 (2022) — Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots. · Journal of ethnopharmacology
8.PMID: 39442279 (2024) — Total alkaloids of Aconitum carmichaelii Debx alleviate cisplatin-induced acute renal injury by inhibiting inflammation and oxidative stress related to gut microbiota metabolism. · Phytomedicine : international journal of phytotherapy and phytopharmacology
9.PMID: 32186025 (2019) — Effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on excisional wound healing in a rat's model. · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
10.PMID: 36257343 (2023) — Ethnopharmacological use, pharmacology, toxicology, phytochemistry, and progress in Chinese crude drug processing of the lateral root of Aconitum carmichaelii Debeaux. (Fuzi): A review. · Journal of ethnopharmacology
11.PMID: 25479152 (2015) — A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux. · Journal of ethnopharmacology
12.PMID: 36174719 (2022) — Diterpenoids with anti-inflammatory activity from the lateral root of Aconitum carmichaelii debeaux. · Phytochemistry
13.PMID: 29636787 (2018) — Ma-Huang-Fu-Zi-Xi-Xin Decoction for Allergic Rhinitis: A Systematic Review. · Evidence-based complementary and alternative medicine : eCAM
14.PMID: 31837236 (2020) — Neuropharmacological effects of Aconiti Lateralis Radix Praeparata. · Clinical and experimental pharmacology & physiology
15.PMID: 36504130 (2023) — Root endophytic bacterial community composition of Aconitum carmichaelii debx. from three main producing areas in China. · Journal of basic microbiology
16.PMID: 36324672 (2022) — Processed lateral root of Aconitum carmichaelii Debx.: A review of cardiotonic effects and cardiotoxicity on molecular mechanisms. · Frontiers in pharmacology
17.PMID: 34315520 (2021) — The toxicology and detoxification of Aconitum: traditional and modern views. · Chinese medicine
18.PMID: 22469654 (2012) — Aconitum alkaloid content and the high toxicity of aconite tincture. · Forensic science international
19.PMID: 35161335 (2022) — Higenamine in Plants as a Source of Unintentional Doping. · Plants (Basel, Switzerland)
20.PMID: 35698356 (2022) — Polysaccharides from Aconitum carmichaelii leaves: Structure, immunomodulatory and anti-inflammatory activities. · Carbohydrate polymers
21.PMID: 36216199 (2023) — Safety evaluations of the processed lateral root of Aconitum carmichaelii Debx. And its hepatotoxicity mechanisms in rats. · Journal of ethnopharmacology
22.PMID: 29552837 (2018) — [Meta-analysis on efficacy and safety of combination therapy of Aconitum and Western medicine in treatment of rheumatoid arthritis]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
23.PMID: 40751788 (2025) — Metabolism of coclaurine into the WADA-banned substance higenamine: a doping-relevant analytical evaluation of Kampo extracts. · Journal of natural medicines
24.PMID: 36982912 (2023) — Aconitum carmichaelii Debx. Attenuates Heart Failure through Inhibiting Inflammation and Abnormal Vascular Remodeling. · International journal of molecular sciences
25.PMID: 37670420 (2024) — Bioactive polysaccharides in different plant parts of Aconitum carmichaelii. · Journal of the science of food and agriculture
26.PMID: 37958540 (2023) — Virome Analysis of Aconitum carmichaelii Reveals Infection by Eleven Viruses, including Two Potentially New Species. · International journal of molecular sciences
27.PMID: 22567575 (2012) — Quantitative and Qualitative Analysis of Aconitum Alkaloids in Raw and Processed Chuanwu and Caowu by HPLC in Combination with Automated Analytical System and ESI/MS/MS. · Journal of analytical methods in chemistry
28.PMID: 21508072 (2011) — Causes and prevention of herb-induced aconite poisonings in Asia. · Human & experimental toxicology
29.PMID: 7839574 (1994) — Aconitine poisoning due to Chinese herbal medicines: a review. · Veterinary and human toxicology