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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
BS
MetabolicRésumée par IA
Berberine Source
Berberis aquifolium
Soutien du foie et digestif dans la médecine amérindienne
How does berberine in Oregon grape work as an antimicrobial?
Berberine, the primary active compound in Berberis aquifolium, works through multiple antimicrobial mechanisms. It inhibits bacterial adhesion to cell surfaces, disrupts bacterial DNA replication, and interferes with microbial enzyme function. Research demonstrates berberine exhibits antimicrobial activity comparable to tetracycline against certain gastrointestinal pathogens. Additionally, berberine shows antiprotozoal effects against Giardia and antifungal activity against Candida species, making it effective for various intestinal infections. Evidence Level: B.
Does Oregon grape root interact with prescription medications?
Yes, Oregon grape root can interact with several medications. Berberine affects cytochrome P450 enzymes and may alter metabolism of drugs processed by the liver. It can interact with antibiotics, potentially reducing their effectiveness. Berberine may enhance the effects of blood sugar-lowering medications and blood thinners. Those taking cyclosporine, macrolide antibiotics, or medications metabolized by CYP450 should consult a healthcare provider before use. Evidence Level: B.
What is the recommended dosage for Oregon grape root extract?
The standard adult dosage for Berberis aquifolium root extract is 500 mg taken three times daily. This dosing provides therapeutic levels of berberine for antimicrobial and liver support applications. For digestive support, the extract is typically taken with meals. Duration of use should be limited, and treatment should be supervised by a qualified healthcare practitioner. Individual needs may vary based on the condition being addressed. Evidence Level: B, Traditional.
Is Oregon grape root safe during pregnancy and breastfeeding?
Oregon grape root is contraindicated during pregnancy and breastfeeding. Berberine can cross the placenta and stimulate uterine contractions, potentially causing miscarriage. It also passes into breast milk and may harm nursing infants. Neonates should not be exposed to berberine-containing herbs due to risks of kernicterus. Women who are pregnant, nursing, or attempting to conceive should avoid all Berberis species products. Evidence Level: B.
Can Oregon grape help with psoriasis and skin inflammation?
Yes, Berberis aquifolium has traditional and evidence-based use for skin conditions including psoriasis. The berberine content demonstrates anti-inflammatory and antimicrobial properties that may help reduce skin inflammation and support healing. Native American medicine has long used this herb for various skin diseases. Topical and internal preparations have been studied for dermatological applications. Consult a healthcare provider for appropriate formulation and duration of treatment. Evidence Level: B, Traditional.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids found in plants such as Berberis aquifolium [PMID:27671811]. It is recognized for its wide range of pharmacological activities, including anti-inflammatory, antidiabetic, and antimicrobial effects [PMID:32735398, PMID:10767672].
Contexte
Berberis aquifolium, also known as Oregon grape, is a plant source of the alkaloid berberine [PMID:27671811, PMID:10767672]. The alkaloid is located in the roots, rhizomes, and stem bark of the plant [PMID:10767672].
Usages traditionnels
Plants of the genus Mahonia have a long history of use in Traditional Chinese Medicine (TCM) for treating tuberculosis, periodontitis, dysentery, pharyngolaryngitis, eczema, and wounds [PMID:26387740]. In TCM theory, these species are used to relieve internal heat, eliminate dampness, remove toxins, suppress pain, promote blood circulation, inhibit cough, and alleviate inflammation [PMID:26387740]. Berberine also has a history of use in Ayurvedic and Chinese medicine [PMID:10767672].
Composés actifs
The primary active compound is berberine, a protoberberine isoquinoline alkaloid [PMID:27671811]. Other identified compounds in Mahonia aquifolium include berbamine, oxyacanthine [PMID:7997469], jatrorrhizine [PMID:11943071], norisocorydine, liriodenine, liriodendrine, sinomenine, and glaucine [PMID:40674142].
Mécanisme d'action
Berberine exerts anti-inflammatory and antioxidant activities [PMID:27671811]. It may operate through the Nrf2 signaling pathway to preserve redox balance [PMID:31609017]. In cancer cells, it acts by inducing apoptosis and autophagy, arresting the cell cycle, and inhibiting metastasis and invasion [PMID:32735398]. Additionally, Oregon grape root extracts have been shown to inhibit P-glycoprotein mediated efflux of certain drugs in vitro [PMID:38304488].
Preuves cliniques
Preuve BPsoriasis
Topical Mahonia aquifolium cream showed statistically significant improvement in PASI score and Dermatology Life Quality Index after 4 weeks of treatment [PMID:16148424].
Preuve BLipid levels and Insulin resistance
Lipid-lowering and insulin-resistance improving actions have been demonstrated in numerous randomized clinical trials [PMID:27671811].
Preuve CInfections
Predominant clinical uses include bacterial diarrhea, intestinal parasite infections, and ocular trachoma infections [PMID:10767672].
Interactions médicamenteuses
Oregon grape root extracts (0.1-1 mg/mL) inhibited the efflux of cyclosporine A (CsA) and digoxin in Caco-2 cells in vitro [PMID:38304488].
Synthèse des preuves
Evidence ranges from in vitro and animal studies (D) to clinical trials (B) and systematic reviews (A). Strongest clinical evidence supports its use for lipid management, insulin resistance, and topical treatment of psoriasis.
Sources PubMed
1.PMID: 27671811 (2016) — Berberine and Its Role in Chronic Disease. · Advances in experimental medicine and biology
2.PMID: 10767672 (2000) — Berberine. · Alternative medicine review : a journal of clinical therapeutic
3.PMID: 16148424 (2005) — A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis. · American journal of therapeutics
4.PMID: 32735398 (2020) — Berberine: A novel therapeutic strategy for cancer. · IUBMB life
5.PMID: 38304488 (2023) — Effect of Oregon grape root extracts on P-glycoprotein mediated transport in in vitro cell lines. · Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 26387740 (2015) — The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review. · Journal of ethnopharmacology
7.PMID: 40674142 (2025) — Bioactive isoquinoline alkaloids from Mahonia aquifolium (pursh.) Nutt acclimatized to natural conditions in Georgia. · Natural product research
8.PMID: 7997469 (1994) — The antipsoriatic Mahonia aquifolium and its active constituents; I. Pro- and antioxidant properties and inhibition of 5-lipoxygenase. · Planta medica
9.PMID: 11943071 (2002) — Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. · BMC complementary and alternative medicine
10.PMID: 31609017 (2020) — Therapeutic and biological activities of berberine: The involvement of Nrf2 signaling pathway. · Journal of cellular biochemistry