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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Chlorella vulgaris is a green unicellular microalgae with diverse biological and pharmacological properties beneficial for human health [PMID:26561078, PMID:40985044].
Contexte
Chlorella vulgaris is a freshwater, unicellular green microalga found widely in East Asian countries such as China, Korea, and Japan [PMID:40985044, PMID:39556490]. It is utilized as a food source, dietary supplement, and in various biotechnological, pharmaceutical, and cosmetic applications [PMID:26561078, PMID:39767096].
Usages traditionnels
It has a long history of use as a food source [PMID:26561078].
Composés actifs
C. vulgaris contains proteins, omega-3 polyunsaturated fatty acids, polysaccharides, vitamins, minerals, carotenes, and chlorophyll [PMID:26561078, PMID:30000882]. Specific active compounds extracted from the algae include dodecanoic acid and loliolide [PMID:40985044].
Mécanisme d'action
C. vulgaris may prevent histamine release by blocking extracellular Ca2+ uptake into mast cells and inhibit serum IgE overproduction via induction of T helper 1 (Th1) skewing dependent on interferon-γ (IFN-γ) and interleukin 12 (IL-12) secretion [PMID:23426977]. It may also modulate gut microbiota, increase short-chain fatty acid (SCFA) production, and promote the expansion of regulatory T cell (Treg) populations [PMID:37571230]. Additionally, it has been suggested to work for PAH-detoxification through epigenetic modulation, specifically reducing global hypermethylation (5-methylcytosine) [PMID:26432772].
Preuves cliniques
Preuve BHyperlipidemia and Hyperglycemia
Clinical trials suggest supplementation can ameliorate these conditions [PMID:26561078]
Preuve BOxidative Stress, Cancer, and COPD
Clinical trials suggest supplementation can protect against these conditions [PMID:26561078]
Preuve BPAH Exposure (Detoxification)
A randomized, double-blind, cross-over trial in healthy females showed reduced global hypermethylation and reduced levels of urinary 1-hydroxypyrene [PMID:26432772]
Preuve DAllergic Immune Response
Water extract (CVE) demonstrated antihistamine activity in rat peritoneal mast cells and inhibited serum IgE overproduction in OVA-immunised mice [PMID:23426977]
Preuve DColitis
In a DSS-induced colitis mouse model, C. vulgaris intervention alleviated pathological symptoms and increased Treg levels [PMID:37571230]
Sécurité et effets indésirables
Generally well tolerated, but may cause nausea, diarrhea, abdominal cramping, flatulence, and green stools [PMID:30000882]. Allergic reactions, including asthma and anaphylaxis, have been reported in users and those preparing tablets; photosensitivity reactions have also occurred following ingestion [PMID:30000882].
Grossesse et allaitement
Supplements during pregnancy may decrease dioxin content and increase carotenes and immunoglobulin A in breastmilk [PMID:30000882]. Intake is probably acceptable during breastfeeding and not expected to cause adverse effects in most infants, though green breastmilk discoloration has been reported [PMID:30000882].
Interactions médicamenteuses
The high vitamin K content of Chlorella may decrease the effectiveness of warfarin [PMID:30000882].
Synthèse des preuves
Evidence ranges from review-based claims of clinical benefits (C) and specific randomized clinical trials on epigenetic modulation (B) to animal and in-vitro studies (D) regarding immune regulation and toxicity.
Sources PubMed
1.PMID: 26561078 (2016) — Chlorella vulgaris: A Multifunctional Dietary Supplement with Diverse Medicinal Properties. · Current pharmaceutical design
2.PMID: 30000882 (2006) — Photosynthesis Responses of Tibetan Freshwater Algae Chlorella vulgaris to Herbicide Glyphosate. · International journal of environmental research and public health
3.PMID: 39556490 (2024) — Chlorella vulgaris as a food substitute: Applications and benefits in the food industry. · Journal of food science
4.PMID: 40985044 (2026) — Chlorella vulgaris, a representative edible algae as integrative and alternative medicine. · Integrative medicine research
5.PMID: 39767096 (2024) — Advances in Bioprocess Engineering for Optimising Chlorella vulgaris Fermentation: Biotechnological Innovations and Applications.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 23426977 (2013) — Inhibitory effect of unicellular green algae (Chlorella vulgaris) water extract on allergic immune response. · Journal of the science of food and agriculture
7.PMID: 26432772 (2015) — Epigenetic modulation of Chlorella (Chlorella vulgaris) on exposure to polycyclic aromatic hydrocarbons. · Environmental toxicology and pharmacology
8.PMID: 37571230 (2023) — Chlorella vulgaris Modulates Gut Microbiota and Induces Regulatory T Cells to Alleviate Colitis in Mice. · Nutrients