Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Cnidium monnieri increase testosterone levels?
Cnidium monnieri contains osthol, a coumarin compound that has demonstrated testosterone-enhancing properties in preclinical research. Osthol appears to stimulate testosterone production by acting on Leydig cells in the testes and may influence key enzymes involved in steroidogenesis. The herb also contains isopimpinellin and bergapten, which contribute to its bioactive profile. Evidence level C indicates these findings come primarily from laboratory and animal studies, with limited human clinical trials. In Traditional Chinese Medicine, the herb tonifies kidney yang, which correlates with reproductive and hormonal vitality.
Does Cnidium monnieri interact with any medications?
Cnidium monnieri contains photosensitizing furocoumarins including methoxsalen, bergapten, and xanthotoxol, which may increase sensitivity to ultraviolet light. These compounds can potentially interact with photosensitizing medications such as tetracyclines, fluoroquinolones, sulfonamides, and retinoids, compounding sun sensitivity reactions. Limited clinical interaction data exists (Evidence level C). Patients taking immunosuppressants or medications metabolized by liver enzymes should exercise caution. Always consult a healthcare provider before combining Cnidium monnieri with prescription medications.
What is the recommended dosage for Cnidium monnieri?
The standard adult dosage for Cnidium monnieri is 3-9 grams of dried fruit daily, typically prepared as a decoction. For standardized extracts, 300mg daily is commonly used. For external skin conditions, the herb can be prepared as a wash or incorporated into topical formulations. Take internal doses with food to reduce gastrointestinal upset. Dosage should be adjusted based on individual constitution and condition severity. Children should not use Cnidium monnieri internally. Consult a qualified practitioner for personalized dosing recommendations.
Is Cnidium monnieri safe during pregnancy?
Cnidium monnieri is contraindicated during pregnancy and should be strictly avoided. The herb contains osthol and other coumarin compounds that may stimulate uterine contractions and potentially affect fetal development. Traditional Chinese Medicine classifies Cnidium monnieri as unsafe for pregnant women. Breastfeeding women should also avoid use due to insufficient safety data. Women with yin deficiency accompanied by heat signs should not use this herb. Always consult a healthcare provider before using any herbal supplements during pregnancy or while nursing.
What is Cnidium monnieri used for in traditional Chinese medicine?
In Traditional Chinese Medicine, Cnidium monnieri (She Chuang Zi) is primarily used to warm kidney yang and treat yang deficiency patterns manifesting as impotence, infertility, and cold-damp conditions. Externally, it is valued for treating vaginal itching, eczema, scabies, and various skin conditions due to its antifungal, antibacterial, and antiparasitic properties. The dried fruits are prepared as decoctions for internal use or washes for external application. Evidence level C indicates traditional use is well-documented, though modern clinical trials remain limited.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Cnidium monnieri is a traditional Asian medicinal herb from the Apiaceae family known for its diverse pharmacological properties, primarily attributed to coumarin compounds like osthole [PMID:26243582, PMID:32028721].
Contexte
Cnidium monnieri (L.) Cusson is an annual plant of the Umbelliferae/Apiaceae family widely grown and used in China, Japan, Korea, and Vietnam [PMID:26243582, PMID:32028721, PMID:38909038]. It is known as 'She chuang zi' in China, 'Jashoshi' in Japan, 'Sasangia' in Korea, and 'Xa sang tu' in Vietnam [PMID:32028721].
Usages traditionnels
The fruits have been used traditionally to treat a variety of diseases, including female genital issues, male impotence, frigidity, skin-related diseases, traumatic injury with blood stasis ('pusun yuxue'), rheumatic arthralgia ('fengshi bitong'), and tinea and sores ('xuan chuang') [PMID:26243582, PMID:41406561].
Composés actifs
The plant contains coumarins, volatile constituents, liposoluble compounds, chromones, monoterpenoid glucosides, terpenoids, and glycosides [PMID:32028721]. A primary active constituent is osthole [PMID:26243582, PMID:28513464], and other identified coumarins include imperatorin, xanthotoxin, cindimine, isopimpinellin, marmesin, isoimperatorin, and bergapten [PMID:37241850, PMID:38673809].
Mécanisme d'action
Osthole promotes osteogenic differentiation by activating Wnt/β-catenin and BMP-2/Smad1/5/8 signaling pathways while suppressing RANKL-induced osteoclastogenesis [PMID:37680712]. It antagonizes microglial activation in an NRF2-dependent manner [PMID:36677566]. In cancer, it inhibits proliferation, induces apoptosis, and inhibits invasion, migration, and angiogenesis [PMID:36160431]. It also inhibits phosphodiesterase 4D activity for airway relaxation [PMID:37450901] and noncompetitively inhibits urate transporter 1 (URAT1) [PMID:30388753].
Preuves cliniques
Preuve AOsteoporosis
Osthole increases osteoblast-related bone formation and decreases osteoclast-related bone resorption in rat models [PMID:37680712, PMID:35980123].
Preuve DAtopic Dermatitis/Pruritus
Osthole ameliorates chronic pruritus and improves skin damage by inhibiting IL-31 production in mouse models [PMID:40256714].
Preuve DHypertension
Cnidium monnieri fruit ethanol extract shows concentration-dependent vasorelaxation in rats via an endothelium-independent mechanism [PMID:38673809].
Preuve DBreast Cancer Bone Metastasis
Osthole reduced bone metastases and tumor burden in murine models by regulating OPG/RANKL signals [PMID:28938572].
Preuve DHepatocellular Carcinoma
Network pharmacology suggests active phytochemicals in C. monnieri are implicated in treating HCC [PMID:35628212].
Sécurité et effets indésirables
Osthole is described as having a moderate absorption rate and rapid metabolic characteristics, though its toxicological effects are noted as not yet fully clear [PMID:39327653].
Synthèse des preuves
The evidence is primarily based on in vitro studies, animal models (rats, mice, fruit flies), and review articles. One systematic review and meta-analysis of rat models supports its use for osteoporosis. There is a lack of human clinical trial data in the provided abstracts.
Sources PubMed
1.PMID: 28513464 (2017) — Pharmacological features of osthole. · Postepy higieny i medycyny doswiadczalnej (Online)
2.PMID: 26243582 (2015) — Cnidium monnieri: A Review of Traditional Uses, Phytochemical and Ethnopharmacological Properties. · The American journal of Chinese medicine
3.PMID: 32028721 (2020) — Phytochemistry, Ethnopharmacology, Pharmacokinetics and Toxicology of Cnidium monnieri (L.) Cusson. · International journal of molecular sciences
4.PMID: 35156581 (2022) — Osthole: Synthesis, Structural Modifications, and Biological Properties. · Mini reviews in medicinal chemistry
5.PMID: 35628212 (2022) — Network-Pharmacology-Based Study on Active Phytochemicals and Molecular Mechanism of Cnidium monnieri in Treating Hepatocellular Carcinoma. · International journal of molecular sciences
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 38909038 (2024) — Chromosome-level genome assembly of Cnidium monnieri, a highly demanded traditional Chinese medicine. · Scientific data
7.PMID: 37680712 (2023) — Review on the protective activity of osthole against the pathogenesis of osteoporosis. · Frontiers in pharmacology
8.PMID: 40256714 (2025) — Osthole ameliorates chronic pruritus in 2,4-dichloronitrobenzene-induced atopic dermatitis by inhibiting IL-31 production. · Chinese herbal medicines
9.PMID: 31818000 (2019) — Fingerprint Analysis of Cnidium monnieri (L.) Cusson by High-Speed Counter-Current Chromatography. · Molecules (Basel, Switzerland)
10.PMID: 38053552 (2023) — Biosynthesis, characterization, and antifungal activity of plant-mediated silver nanoparticles using Cnidium monnieri fruit extract. · Frontiers in microbiology
11.PMID: 36677566 (2023) — Osthole Antagonizes Microglial Activation in an NRF2-Dependent Manner. · Molecules (Basel, Switzerland)
12.PMID: 36160431 (2022) — Osthole: An up-to-date review of its anticancer potential and mechanisms of action. · Frontiers in pharmacology
13.PMID: 37176844 (2023) — Cnidium monnieri (L.) Cusson Flower as a Supplementary Food Promoting the Development and Reproduction of Ladybeetles Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae). · Plants (Basel, Switzerland)
14.PMID: 41349703 (2026) — Anti-acne mechanisms of Yuqingyan, a novel multi-herbal formula derived from traditional Chinese medicine. · Journal of ethnopharmacology
16.PMID: 30388753 (2018) — Effects of Osthol Isolated from Cnidium monnieri Fruit on Urate Transporter 1. · Molecules (Basel, Switzerland)
17.PMID: 34376964 (2021) — Osthole: an overview of its sources, biological activities, and modification development. · Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents
18.PMID: 39327653 (2024) — Osthole, a Coumarin from Cnidium monnieri: A Review on Its Pharmacology, Pharmacokinetics, Safety, and Innovative Drug Delivery Platforms. · The American journal of Chinese medicine
19.PMID: 42339049 (2026) — Preparation and pharmacological study of Cnidium monnieri volatile oil cream. · Biomedical reports
20.PMID: 37241850 (2023) — Nematicidal Coumarins from Cnidium monnieri Fruits and Angelica dahurica Roots and Their Physiological Effect on Pine Wood Nematode (Bursaphelenchus xylophilus). · Molecules (Basel, Switzerland)
21.PMID: 35980123 (2022) — Effects of osthole on osteoporotic rats: a systematic review and meta-analysis. · Pharmaceutical biology
22.PMID: 41470681 (2025) — Analysis of the Factors Affecting Germination of Cnidium monnieri Seeds and Its Endogenous Inhibitory Substances. · Plants (Basel, Switzerland)
23.PMID: 41600088 (2026) — Research Progress on the Insecticidal and Antibacterial Properties and Planting Applications of the Functional Plant Cnidium monnieri in China. · Plants (Basel, Switzerland)
24.PMID: 32646359 (2021) — Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities. · Mini reviews in medicinal chemistry
25.PMID: 38673809 (2024) — Vasorelaxant and Blood Pressure-Lowering Effects of Cnidium monnieri Fruit Ethanol Extract in Sprague Dawley and Spontaneously Hypertensive Rats. · International journal of molecular sciences
26.PMID: 41406561 (2026) — Osthole promotes skin flap survival by inhibiting ferroptosis and alleviating pyroptosis. · Journal of ethnopharmacology
27.PMID: 37450901 (2023) — Biosynthesis of the Plant Coumarin Osthole by Engineered Saccharomyces cerevisiae. · ACS synthetic biology
29.PMID: 24879527 (2014) — New coumarins and anti-inflammatory constituents from the fruits of Cnidium monnieri. · International journal of molecular sciences
30.PMID: 28938572 (2017) — Osthole inhibits bone metastasis of breast cancer. · Oncotarget