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How does Coreopsis tinctoria work to lower blood sugar?
Coreopsis tinctoria contains bioactive flavonoids, particularly marein and okanin, which may support blood sugar regulation through multiple pathways. These compounds appear to enhance glucose uptake in cells and support pancreatic beta-cell function. The chalcones present in the plant demonstrate antioxidant activity that may protect against oxidative stress associated with diabetes. However, human clinical trials are limited, and the precise mechanisms require further research. Evidence level: C (preliminary evidence from in vitro and animal studies).
Does Coreopsis tinctoria interact with diabetes medications?
Coreopsis tinctoria may potentially interact with antidiabetic medications due to its blood sugar-lowering effects. Combining this herb with insulin or oral hypoglycemic agents could theoretically cause additive effects, leading to hypoglycemia. Limited clinical data exists on specific interactions. Patients taking metformin, sulfonylureas, or other diabetes medications should consult a healthcare provider before using Coreopsis tinctoria and monitor blood glucose levels closely. Evidence level: C (theoretical risk based on mechanism of action).
What is the recommended dosage for Coreopsis tinctoria tea?
The traditional adult dosage for Coreopsis tinctoria is 3-5 grams of dried flowers prepared as a tea, taken twice daily. To prepare, steep the dried flowers in hot water for 10-15 minutes before straining. Standardized extracts are not widely available, and optimal therapeutic dosing has not been established through clinical trials. Start with lower doses to assess tolerance and increase gradually if needed. Evidence level: C/Traditional (based on ethnobotanical use rather than clinical studies).
Is Coreopsis tinctoria safe during pregnancy and breastfeeding?
Coreopsis tinctoria is considered unsafe during pregnancy and should be avoided. The plant contains compounds that may stimulate uterine contractions or affect fetal development, though specific teratogenic studies are lacking. There is insufficient safety data for breastfeeding women, so use is not recommended during lactation either. Women who are pregnant, planning pregnancy, or nursing should consult a qualified healthcare provider for alternative remedies. Evidence level: D (insufficient human safety data; precautionary avoidance recommended).
What are the side effects of Coreopsis tinctoria?
Coreopsis tinctoria is generally well-tolerated at recommended doses. Reported side effects are primarily mild gastrointestinal upset, including nausea or stomach discomfort in some individuals. People with known allergies to plants in the Asteraceae family, such as ragweed, marigolds, chamomile, or daisies, should avoid Coreopsis tinctoria due to potential allergic reactions. No serious adverse events have been documented in available literature, though comprehensive safety studies remain limited. Evidence level: C.
What is Coreopsis tinctoria used for in traditional medicine?
Coreopsis tinctoria has been used traditionally by Navajo and other North American indigenous peoples primarily for digestive complaints and respiratory conditions. The dried flowers were prepared as tea to address stomach discomfort, coughs, and breathing difficulties. The plant has also gained research attention for potential blood sugar regulation properties. Additionally, Coreopsis tinctoria has a long history as a natural dye plant, producing yellow to reddish-brown colors for textiles. Evidence level: C/Traditional (historical use with limited clinical validation).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Coreopsis tinctoria is a traditional medicinal plant used in North America, Europe, and Asia, recognized for its antioxidant, antihyperglycemic, and anti-inflammatory properties [PMID:33309917, PMID:38919005].
Contexte
Coreopsis tinctoria Nutt. (family Asteraceae), also known as 'Snow Chrysanthemum' or 'Shemuju', is a medicinal plant found in plateau areas exceeding 3000m, particularly in regions like Xinjiang, China [PMID:33309917, PMID:38084786, PMID:24228578].
Usages traditionnels
It has been used traditionally for disinfection, treatment of sexual infections, diarrhea, acute and chronic dysentery, red-eye swelling, pain, heat, thirst, hypertension, palpitation, gastrointestinal discomfort, and loss of appetite [PMID:33309917]. In Portugal, flowering tops infusion is used for diabetes symptoms [PMID:22143153], and in Xinjiang, it is consumed as a herbal tea for high blood pressure and diarrhea [PMID:30630477].
Composés actifs
The plant is rich in flavonoids, including marein, flavanomarein, okanin, kaempferol, quercetin, and isorhamnetin [PMID:35334817, PMID:36570002, PMID:35962784, PMID:40437103]. Other identified compounds include polyacetylenes [PMID:25563069], biflavonones (sikokianin D and E) [PMID:28374625], and various chalcones and flavanones [PMID:30499349, PMID:36630026].
Mécanisme d'action
Mechanisms include the modulation of SIRT1/Nrf2 signaling to alleviate oxidative stress and lipid accumulation [PMID:40437103], inhibition of IKKβ-mediated NF-κB p65 phosphorylation to protect against bone loss [PMID:41109043], and regulation of TGF-β1/SMADS/AMPK/NF-κB pathways to reduce renal fibrosis [PMID:30630477]. It also acts via SIRT3 pathways to protect against UVA-induced mitochondrial dysfunction [PMID:41008947] and modulates Nrf2/HO-1 and MAPK pathways for neuroprotection [PMID:41906277].
Preuves cliniques
Preuve DHyperglycemia/Diabetes
C. tinctoria and its flavonoids lowered body weight, reduced fasting blood glucose, and improved glucose tolerance and insulin resistance in obese mice [PMID:35334817]; reversed levels of glucose, insulin, and HbA1c in db/db mice [PMID:36736673].
Preuve DHyperlipidemia
Flavonoids from C. tinctoria adjusted lipid metabolism by down-regulating adipose differentiation-related protein (ADRP) in hyperlipemia mice [PMID:25512113].
Preuve DSkin Photoaging
Okanin reduced malondialdehyde content and relieved epidermal hyperplasia and dermal damage caused by UVB irradiation in mice [PMID:39024749].
Preuve DOsteoporosis
Okanin attenuated ovariectomy-induced bone loss in a murine model [PMID:41109043].
Preuve DChronic Myelogenous Leukemia (CML)
Flower extracts were investigated for their ability to impair CML cell survival (K562 cells) [PMID:38919005].
Preuve DCerebral Injury
Synthèse des preuves
The evidence consists primarily of in vitro cell studies and in vivo animal models (mice/rats), indicating strong potential for metabolic and antioxidant activity, but lacks human clinical trials.
Sources PubMed
1.PMID: 33309917 (2021) — Traditional uses, phytochemistry, pharmacology, and toxicology of Coreopsis tinctoria Nutt.: A review. · Journal of ethnopharmacology
2.PMID: 28374625 (2017) — Two new biflavonones from Coreopsis tinctoria. · Journal of Asian natural products research
4.PMID: 25563069 (2015) — Novel polyacetylenes from Coreopsis tinctoria Nutt. · Journal of Asian natural products research
5.PMID: 35334817 (2022) — Coreopsis tinctoria and Its Flavonoids Ameliorate Hyperglycemia in Obese Mice Induced by High-Fat Diet. · Nutrients
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Polyphenols ameliorated acrylamide-induced gait abnormalities and reduced brain injury markers MBP and GFAP in mice [PMID:41906277].
6.PMID: 36570002 (2022) — Metabolomics study of flavonoids in Coreopsis tinctoria of different origins by UPLC-MS/MS. · PeerJ
7.PMID: 34691233 (2021) — Protective Effect of Effective Components of Coreopsis tinctoria Nutt on Retinopathy of db/db Diabetic Mice. · Evidence-based complementary and alternative medicine : eCAM
8.PMID: 38496841 (2024) — Coreopsis tinctoria improves energy metabolism in obese hyperglycemic mice. · Heliyon
9.PMID: 40437103 (2025) — Marein from Coreopsis tinctoria Nutt. alleviates oxidative stress and lipid accumulation via SIRT1/Nrf2 signaling. · Scientific reports
10.PMID: 35962784 (2022) — Study on the metabolism profile of flavanomarein in Coreopsis tinctoria Nutt. · Journal of separation science
11.PMID: 32464313 (2020) — Okanin in Coreopsis tinctoria Nutt is a major quorum-sensing inhibitor against Chromobacterium violaceum. · Journal of ethnopharmacology
12.PMID: 25512113 (2014) — Flavonoids furom Coreopsis tinctoria adjust lipid metabolism in hyperlipidemia animals by down-regulating adipose differentiation-related protein. · Lipids in health and disease
13.PMID: 41395282 (2025) — Integrated network pharmacology and experimental validation reveal Coreopsis tinctoria Total Flavonoids (CTFs) as potential therapeutic agents against hepatocellular carcinoma. · American journal of cancer research
14.PMID: 41109043 (2025) — Okanin attenuates ovariectomy-induced bone loss in mice model through inhibition of IKKβ-mediated NF-κB p65 phosphorylation. · Phytomedicine : international journal of phytotherapy and phytopharmacology
15.PMID: 35993096 (2022) — Supercritical CO2 extraction, chemical composition, and antioxidant effects of Coreopsis tinctoria Nutt. oleoresin. · Open life sciences
16.PMID: 30630477 (2019) — Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-β1/SMADS/AMPK/NF-κB pathways. · BMC complementary and alternative medicine
17.PMID: 38084786 (2024) — UPLC-quadrupole time-of-flight-tandem mass spectrometry combined with chemometrics and network pharmacology to differentiate Coreopsis tinctoria Nutt. · Biomedical chromatography : BMC
18.PMID: 32372278 (2020) — Detection of 16SrVI and 16SrIX phytoplasma groups in pot marigold and tickseed plants in northeastern Iran. · Folia microbiologica
19.PMID: 35356116 (2022) — Comparison of Metabolome and Transcriptome of Flavonoid Biosynthesis in Two Colors of Coreopsis tinctoria Nutt. · Frontiers in plant science
20.PMID: 36736673 (2023) — Protective effects of flavonoids in Coreopsis tinctoria Nutt. in a mouse model of type 2 diabetes. · Journal of ethnopharmacology
21.PMID: 39024749 (2024) — Anti-photoaging effect and the mechanism of Coreopsis tinctoria okanin against UVB-induced skin damage in mice. · International immunopharmacology
22.PMID: 41008947 (2025) — Okanin Attenuates Mitochondrial Dysfunction and Apoptosis in UVA-Induced HaCaT Cells by Mitophagy Through SIRT3 Pathway. · Antioxidants (Basel, Switzerland)
23.PMID: 22143153 (2012) — Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells. · Journal of ethnopharmacology
24.PMID: 30499349 (2020) — The chemical components of Coreopsis tinctoria Nutt. and their antioxidant, antidiabetic and antibacterial activities. · Natural product research
25.PMID: 39509897 (2025) — Gradient ethanol extracts of Coreopsis tinctoria buds: Chemical and in vitro fermentation characteristics. · Food chemistry
26.PMID: 41906277 (2026) — Coreopsis tinctoria Nutt. polyphenols attenuate acrylamide-induced cerebral injury via dual modulation of Nrf2/HO-1 and MAPK pathways. · Journal of the science of food and agriculture
27.PMID: 34434650 (2021) — Physiological changes and transcript identification in Coreopsis tinctoria Nutt. in early stages of salt stress. · PeerJ
28.PMID: 40526161 (2025) — Coreopsis Tinctoria flavonoids phospholipid complex: molecular dynamics simulation, preparation, characterization, and in vitro release. · Drug development and industrial pharmacy
29.PMID: 36630026 (2023) — Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.). · Journal of natural medicines
30.PMID: 24228578 (2013) — [Research advance in medicinal plants from genus Coreopsis]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica