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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 18 articles PubMed · modèle : gemma4:31b
Résumé
Black elderflower (Sambucus nigra) is traditionally used to treat colds, flu, and inflammatory conditions [PMID: 36559324, 34443417, 9324006].
Contexte
Sambucus nigra flowers are a plant tissue rich in polyphenolic phytochemicals used in various pharmaceutical forms, including teas, syrups, and extracts [PMID: 36559324, 32093048, 27162290].
Usages traditionnels
Traditionally used for the relief of early symptoms of the common cold [PMID: 34443417], treatment of colds and flu [PMID: 36559324], and in Turkish folk medicine for inflammatory diseases such as rheumatism, fever, infections, and edemas [PMID: 9324006]. In Poland, it has been used in syrups for feverishness accompanying upper respiratory tract infections in children [PMID: 27162290].
Composés actifs
The chemical composition mainly consists of polyphenolic compounds, including flavonoids (specifically quercetin 3-rutinoside [PMID: 34356325]), hydroxycinnamic acids, and triterpenes [PMID: 34443417]. Other identified components include lignans [PMID: 27740591], narcissoside [PMID: 36358461], and kynurenic acid [PMID: 24364456].
Mécanisme d'action
Elderflower extracts exhibit antioxidant properties by neutralizing reactive oxygen species (ROS) [PMID: 36559324, 34443417]. Narcissoside may enhance the MiR200a/Nrf-2/GSH axis and mediate MAPK/Akt signaling pathways to resist apoptosis [PMID: 36358461]. Aqueous extracts can induce ATP binding cassette transporter A1 (ABCA1) expression to reduce cholesteryl ester accumulation in foam cells [PMID: 38347122]. Additionally, it has been shown to inhibit proinflammatory activities of periodontal pathogens and inhibit the biosynthesis of inflammatory cytokines such as IL-1alpha, IL-1beta, and TNF-alpha [PMID: 16460254, 9324006].
Preuves cliniques
Preuve DUpper Respiratory Tract Infections/Fever
Used in pharmaceutical syrups for children to treat feverishness accompanying upper respiratory tract infections [PMID: 27162290].
Preuve DPeriodontitis/Inflammation
Aqueous extracts potently inhibit proinflammatory activities of major virulence factors from Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in vitro [PMID: 16460254].
Preuve DAtherosclerosis (Foam Cell Formation)
Aqueous elder extracts induce ABCA1 expression and reduce cholesteryl ester accumulation in aggregated LDL-induced foam cells [PMID: 38347122].
Preuve DNeurodegeneration (Parkinson's Model)
Narcissoside from elderflowers reduced ROS generation and degeneration of dopaminergic neurons in C. elegans and SH-SY5Y cells [PMID: 36358461].
Sécurité et effets indésirables
Flowers from urban areas were found to contain metals (K, Ca, Cu, Rb, Fe, Cr, Zn) at levels below those harmful to humans [PMID: 31808083].
Synthèse des preuves
The current evidence is primarily based on in vitro cell cultures, animal models (C. elegans), and traditional use reports; there are no high-level clinical trials (RCTs) or meta-analyses provided in the source set.
Sources PubMed
1.PMID: 36559324 (2022) — Comparison of the Formulation, Stability and Biological Effects of Hydrophilic Extracts from Black Elder Flowers (Sambucus nigra L.). · Pharmaceutics
4.PMID: 34443417 (2021) — Biological Actions and Molecular Mechanisms of Sambucus nigra L. in Neurodegeneration: A Cell Culture Approach. · Molecules (Basel, Switzerland)
5.PMID: 34356325 (2021) — The Physicochemical and Antioxidant Properties of Sambucus nigra L. and Sambucus nigra Haschberg during Growth Phases: From Buds to Ripening.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 31808083 (2020) — Selected metal content and antioxidant capacity of Sambucus nigra flowers from the urban areas versus soil parameters and traffic intensity. · Environmental science and pollution research international
7.PMID: 32093048 (2020) — A Green Extraction Process for Polyphenols from Elderberry (Sambucus nigra) Flowers Using Deep Eutectic Solvent and Ultrasound-Assisted Pretreatment. · Molecules (Basel, Switzerland)
8.PMID: 10888553 (2000) — Olfactory and quantitative analysis of aroma compounds in elder flower (Sambucus nigra L.) drink processed from five cultivars. · Journal of agricultural and food chemistry
9.PMID: 16460254 (2006) — Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra). · Journal of periodontology
10.PMID: 24364456 (2013) — Kynurenic acid content in anti-rheumatic herbs. · Annals of agricultural and environmental medicine : AAEM
11.PMID: 35337239 (2022) — Water soluble microparticles of Sambucus nigra L. (elderberry) as a potential herbal medicine. · Natural product research
12.PMID: 36358461 (2022) — Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson's Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway. · Antioxidants (Basel, Switzerland)
13.PMID: 9324006 (1997) — Inhibitory effects of Turkish folk remedies on inflammatory cytokines: interleukin-1alpha, interleukin-1beta and tumor necrosis factor alpha. · Journal of ethnopharmacology
14.PMID: 27740591 (2016) — Effects of Phytoestrogen Extracts Isolated from Elder Flower on Hormone Production and Receptor Expression of Trophoblast Tumor Cells JEG-3 and BeWo, as well as MCF7 Breast Cancer Cells. · Nutrients
15.PMID: 22112724 (2011) — Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret® against viruses causing respiratory infections. · Phytomedicine : international journal of phytotherapy and phytopharmacology
16.PMID: 1639901 (1992) — Separation of flavonol-2-O-glycosides from Calendula officinalis and Sambucus nigra by high-performance liquid and micellar electrokinetic capillary chromatography. · Journal of chromatography