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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Fennel (Foeniculum vulgare) is a medicinal and aromatic herb used for various health benefits, including the management of menopausal symptoms and dysmenorrhea [PMID:33725577, PMID:34187122].
Contexte
Fennel (Foeniculum vulgare Mill) is a hardy, perennial member of the Apiaceae family native to Mediterranean shores but widespread globally [PMID:36803269]. It is valued for its essential oils used in pharmaceutical, culinary, and industrial applications [PMID:40892151].
Usages traditionnels
Fennel has been used in traditional medicine as a galactogogue to increase milk supply [PMID:30000852] and in traditional Chinese medicine (Suoquan Pill) to enhance the effect of reducing urine output [PMID:33287495].
Composés actifs
The volatile oil of fennel is primarily composed of anethole (specifically trans-anethole), fenchone, estragole, 1,8-cineole (eucalyptol), and p-anisaldehyde [PMID:30000852, PMID:37426506, PMID:40335931]. Other identified components include limonene, flavonoids, phenolic acid derivatives, and amino acids [PMID:39732951, PMID:37626070].
Mécanisme d'action
Anethole acts as a phytoestrogen [PMID:30000852]. In experimental models, fennel extract has been shown to decrease oxidant stress, caspase 3, TNF-α, and IL-6 levels while increasing antioxidants [PMID:32510653]. In porcine ovarian cells, it promotes proliferation and IGF-I release while suppressing apoptosis and progesterone release [PMID:37657392].
Preuves cliniques
Preuve AMenopausal symptoms
A meta-analysis of seven RCTs favored fennel for improving menopausal symptoms, although no beneficial effects were seen for sexual function, quality of life, or psychological health [PMID:33725577].
Preuve APrimary dysmenorrhea
Meta-analysis of 12 studies showed that F. vulgare intake significantly decreased the intensity of dysmenorrhea compared to placebo [PMID:34187122].
Preuve BPolycystic Ovarian Syndrome (PCOS)
In a randomized, placebo-controlled trial, fennel significantly decreased the number of ovarian follicles compared to placebo [PMID:37655000].
Preuve BMilk production
Two small studies found increases in milk volume, fat content, and infant weight gain, though no increase in serum prolactin was observed [PMID:30000852].
Preuve AMenstrual bleeding
One meta-analysis revealed fennel oil significantly increased mean bleeding in the first menstrual cycle, but had no significant effect in the second cycle [PMID:31080784].
Sécurité et effets indésirables
Fennel is generally well tolerated [PMID:30000852]. Furocoumarin content in fruits is below safety thresholds at therapeutic doses [PMID:31387269]. However, estragole, a constituent of fennel oil, has shown carcinogenicity in mice, with 1-hydroxy metabolites acting as strong hepatocarcinogens [PMID:11077188].
Grossesse et allaitement
Anethole is excreted in breastmilk [PMID:30000852]. No PubMed data available regarding safety during pregnancy.
Synthèse des preuves
The evidence for fennel's efficacy in treating dysmenorrhea and menopausal symptoms is supported by systematic reviews and meta-analyses (Level A). Evidence for PCOS and lactation is based on smaller clinical trials (Level B). Safety data is mixed, with general tolerability reported, but specific concerns regarding the carcinogenicity of estragole in animal models.
Sources PubMed
1.PMID: 30000852 (2006) — Foeniculum vulgare Mill: a review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. · BioMed research international
2.PMID: 36803269 (2024) — Exploring fennel (Foeniculum vulgare): Composition, functional properties, potential health benefits, and safety. · Critical reviews in food science and nutrition
3.PMID: 40892151 (2025) — Advanced techniques and applications in fennel (Foeniculum vulgare Mill.) breeding. · Molecular genetics and genomics : MGG
4.PMID: 31080784 (2019) — Foeniculum vulgare as Valuable Plant in Management of Women's Health. · Journal of menopausal medicine
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6.PMID: 37426506 (2022) — Antimicrobial and antioxidant activities of fennel oil. · Bioinformation
7.PMID: 33725577 (2021) — Fennel (Foeniculum vulgare Miller) for the management of menopausal women's health: A systematic review and meta-analysis. · Complementary therapies in clinical practice
8.PMID: 41028434 (2025) — Development of Fungal-Resistant Transgenic Fennel Plant. · Methods in molecular biology (Clifton, N.J.)
9.PMID: 11077188 (2000) — Constituents of aromatic plants: II. Estragole. · Fitoterapia
10.PMID: 35009044 (2021) — Foeniculum vulgare Miller, a New Chemotype from Montenegro. · Plants (Basel, Switzerland)
11.PMID: 39732951 (2024) — Foeniculum vulgare Miller bracts, revalorization of a local food waste. · Scientific reports
12.PMID: 37908453 (2023) — Safety and efficacy of feed additives consisting of essential oils from the fruit and stems of Foeniculum vulgare Mill. ssp. vulgare: Bitter fennel oil for use in all animal species and sweet fennel oil for use in dogs and cats (FEFANA asbl). · EFSA journal. European Food Safety Authority
13.PMID: 39361806 (2024) — Foliar-applied silicon and zinc nanoparticles improve plant growth, biochemical attributes, and essential oil profile of fennel (Foeniculum vulgare) under different irrigation regimes. · Functional plant biology : FPB
14.PMID: 34187122 (2021) — Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis. · Journal of complementary & integrative medicine
15.PMID: 34270007 (2021) — Doubled Haploidy for Fennel (Foeniculum vulgare Mill.) and Dill (Anethum graveolens L.). · Methods in molecular biology (Clifton, N.J.)
16.PMID: 37626070 (2023) — Bio-organic fertilizers promote yield, chemical composition, and antioxidant and antimicrobial activities of essential oil in fennel (Foeniculum vulgare) seeds. · Scientific reports
17.PMID: 37655000 (2023) — "Ferula assa-foetida L" or "Foeniculum vulgare"? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded. · Avicenna journal of phytomedicine
18.PMID: 35203880 (2022) — Perspective, Opportunities and Challenges in Using Fennel (Foeniculum vulgare) in Poultry Health and Production as an Eco-Friendly Alternative to Antibiotics: A Review. · Antibiotics (Basel, Switzerland)
19.PMID: 33287495 (2020) — [Research on fennel used in Suoquan Pill]. · Zhonghua yi shi za zhi (Beijing, China : 1980)
20.PMID: 36620493 (2023) — Safety and efficacy of a feed additive consisting of a tincture derived from the fruit of Foeniculum vulgare Mill. ssp. vulgare var. dulce (sweet fennel tincture) for use in all animal species (FEFANA asbl). · EFSA journal. European Food Safety Authority
21.PMID: 29500924 (2018) — The effects of fennel on menstrual bleeding: A systematic review and meta-analysis. · Journal of complementary & integrative medicine
23.PMID: 28846628 (2017) — Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan. · Foods (Basel, Switzerland)
24.PMID: 29755029 (2018) — A double-blind, placebo-controlled trial of Fennel (Foeniculum vulgare) on menopausal symptoms: A high placebo response. · Journal of the Turkish German Gynecological Association
25.PMID: 28509813 (2017) — Effect of Foeniculum vulgare Mill. (fennel) on menopausal symptoms in postmenopausal women: a randomized, triple-blind, placebo-controlled trial. · Menopause (New York, N.Y.)
26.PMID: 32510653 (2020) — Preventative and therapeutic effects of fennel (Foeniculum vulgare) seed extracts against necrotizing enterocolitis. · Journal of food biochemistry
27.PMID: 37657392 (2023) — Fennel affects porcine ovarian cell functions: The interrelationships with the environmental contaminant benzene. · Research in veterinary science
28.PMID: 31387269 (2019) — Furocoumarin Content of Fennel-Below the Safety Threshold. · Molecules (Basel, Switzerland)
29.PMID: 35215391 (2022) — Olfactory Stimulation by Fennel (Foeniculum vulgare Mill.) Essential Oil Improves Lipid Metabolism and Metabolic Disorders in High Fat-Induced Obese Rats. · Nutrients