How does Flemingia macrophylla work for inflammation?

Flemingia macrophylla contains bioactive compounds including flavonoids (genistein, flemichin) and tannins that demonstrate anti-inflammatory and antioxidant properties. These compounds are thought to modulate inflammatory pathways and neutralize free radicals, though the exact mechanism requires further research. Evidence level C indicates limited clinical data, with most support coming from traditional use and preliminary phytochemical studies.

Does Flemingia macrophylla interact with any medications?

There is limited documented evidence regarding drug interactions for Flemingia macrophylla. Due to its flavonoid content, including genistein, theoretical interactions may exist with anticoagulant medications, hormone therapies, or drugs metabolized by certain liver enzymes. Patients taking prescription medications should consult a qualified healthcare provider before using this herb. Evidence level C reflects the need for more research in this area.

What is the recommended dosage for Flemingia macrophylla?

Traditional preparations of Flemingia macrophylla typically use 5-10 grams of dried leaf prepared as a decoction. This dosage is based on folk medicine practice rather than standardized clinical trials. Preparation involves boiling the dried leaves in water. Due to limited clinical evidence (Level C), individuals should follow guidance from a qualified herbalist or healthcare provider and avoid exceeding traditional preparation amounts.

Is Flemingia macrophylla safe during pregnancy?

Flemingia macrophylla is considered unsafe during pregnancy and should be avoided. The herb contains genistein and other isoflavones that may have hormonal effects potentially affecting fetal development. Traditional contraindications explicitly warn against use in pregnant women. Women who are pregnant, nursing, or attempting to conceive should not use this herb without explicit medical supervision.

What is Flemingia macrophylla used for?

Flemingia macrophylla has been used traditionally in Asian folk medicine primarily for joint pain and skin conditions. The herb is also recognized for its anti-inflammatory and antioxidant properties. In some regions, it serves as livestock fodder. Evidence level C indicates that while these uses are well-documented in traditional practice, robust clinical trials are needed to confirm efficacy for these applications.

What are the side effects of Flemingia macrophylla?

Reported side effects of Flemingia macrophylla are generally mild and primarily involve gastrointestinal upset, including nausea or stomach discomfort. These effects are typically associated with oral consumption. Due to limited clinical research (Evidence Level C), the full spectrum of potential adverse effects is not well characterized. Individuals experiencing persistent or severe symptoms should discontinue use and seek medical attention.

Flemingia macrophylla (Flemingia macrophylla)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Flemingia macrophylla is a perennial leguminous shrub of the Fabaceae family with documented anti-inflammatory, antibacterial, and neuroprotective properties [PMID:41402360, PMID:16206038].

Contexte

Flemingia macrophylla is a prominent shrub species within the Fabaceae family widely distributed across China and Southeast Asia [PMID:40419955]. It is characterized by a chromosome-scale genome of approximately 1.01 to 1.13 Gb [PMID:40419955, PMID:41402360].

Usages traditionnels

Roots are traditionally used for treating rheumatism, enhancing blood circulation, and alleviating joint pain [PMID:40419955]. In Taiwan, it is used as a folk remedy for anti-inflammatory purposes, promoting blood circulation, and as an antidiabetes agent [PMID:22719789].

Composés actifs

Primary medicinal components include genistein and genistin [PMID:40457735]. Other identified compounds include isoflavonoids (daidzein, daidzin), prenylated flavonoids, and specific isolated compounds such as fleminigin, flemichin E, fleminginin, flemingichromone, flemingichalcone, and lespedezaflavanone A [PMID:23896592, PMID:16206038, PMID:19942664, PMID:22997529]. The plant also contains condensed tannins [PMID:32604804].

Mécanisme d'action

The herb's isoflavonoids may act as partial estrogen agonists and antagonists [PMID:23896592]. Neuroprotective effects are mediated by activating insulin degrading enzyme (IDE) and inhibiting beta-secretase to attenuate amyloid beta-protein accumulation [PMID:22719789]. Anti-photoaging effects involve scavenging reactive oxygen species and inhibiting MAP kinase and MMP expression [PMID:23935672].

Preuves cliniques

Preuve DInflammation and Pain

Aqueous extracts significantly inhibited acetic acid-induced writhing and formalin-induced licking in mice, and reduced lambda-carrageenan-induced paw edema [PMID:20503477]

Preuve DOsteoporosis

Oral administration of 75% ethanolic extract suppressed bone loss in ovariectomized rats by inhibiting bone resorption [PMID:19942664]

Preuve DHepatotoxicity

Aqueous extract (0.5-1.0 g/kg) decreased ALT and AST levels and ameliorated oxidative stress in CCl4-induced acute liver injury in rats [PMID:21476211]

Preuve DNeuroprotection

Specific flavonoids (e.g., flemingichromone, osajin) protected neuronal cells from Abeta-induced damage in vitro [PMID:16206038]

Preuve DLung Cancer

Prenylated chromones and flavonoids from roots demonstrated cytotoxic activity against A549 and H1975 cells [PMID:37996917]

Sécurité et effets indésirables

A case report described a 68-year-old man who developed acute cholinergic syndrome after ingesting a preparation containing F. macrophylla and ginseng; however, this was attributed to probable pesticide (organophosphate) contamination rather than the herb itself [PMID:18955628].

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant pharmacological potential for anti-inflammatory, hepatoprotective, and neuroprotective activities. No human clinical trials were provided.

Sources PubMed

1.PMID: 41402360 (2025) — Chromosome-scale genome assembly of Flemingia macrophylla. · Scientific data
2.PMID: 40901553 (2025) — Comparative analysis of complete chloroplast genomes of Flemingia prostrata and Flemingia macrophylla, two commonly used medicinal plants in southern China. · Frontiers in plant science
3.PMID: 35179311 (2022) — A push-pull strategy for controlling the tea green leafhopper (Empoasca flavescens F.) using semiochemicals from Tagetes erecta and Flemingia macrophylla. · Pest management science
4.PMID: 23896592 (2013) — Phyto-SERM constitutes from Flemingia macrophylla. · International journal of molecular sciences
5.PMID: 36297706 (2022)

Flemingia macrophylla

Sources et citations

Kunzea Ambigua

Pansit-Pansitan

Frangipani

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Flemingia macrophylla

Sources et citations

Plantes associées

Kunzea Ambigua

Pansit-Pansitan

Frangipani

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales