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PubMed · Comparative plastomes of Pueraria montana var. lobata (Leguminosae: Phaseoleae) and closely related taxa: insights into phylogenomic implications and evolutionary divergence. (2023)
PubMed · Metabolomics of the anti-inflammatory effect of Pueraria lobata and Pueraria lobata var. Thomsonii in rats. (2023)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
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Ge Gen root contains active isoflavones, primarily puerarin, daidzin, and daidzein, which exert multiple pharmacological effects. Puerarin acts as a vasodilator by promoting nitric oxide release and improving microcirculation, explaining its antihypertensive effects. These compounds also modulate neurotransmitter systems and demonstrate anti-inflammatory and antioxidant properties. In Traditional Chinese Medicine terms, Ge Gen releases exterior pathogens, raises clear yang qi, and generates fluids to address conditions like neck stiffness and thirst. Evidence level: C for cardiovascular effects.
Does Ge Gen root interact with blood pressure medications?
Ge Gen root may potentiate the effects of antihypertensive medications due to its vasodilatory properties, particularly from puerarin. Concurrent use with blood pressure-lowering drugs could theoretically cause additive hypotensive effects, leading to dizziness or fainting. Limited clinical evidence exists regarding specific drug interactions (Evidence level: C). Patients taking antihypertensives, anticoagulants, or antiplatelet medications should consult a qualified healthcare provider before using Ge Gen. Always disclose all supplements during medication reviews with your physician.
What is the recommended dosage for Ge Gen root?
The standard adult dosage for Ge Gen root is 9-15 grams of dried root per day when prepared as a decoction. For standardized extracts, 500mg of puerarin daily is commonly used in clinical research. Dosage varies based on the specific condition being treated and individual constitution. In TCM practice, Ge Gen is often combined with other herbs in formulations rather than used alone. Always follow the guidance of a qualified practitioner, as improper dosing may cause gastrointestinal upset or other adverse effects.
Is Ge Gen root safe during pregnancy and breastfeeding?
Ge Gen root is considered unsafe during pregnancy and should be avoided. Traditional Chinese Medicine contraindicates its use in pregnancy due to potential effects on uterine activity and insufficient safety data. The isoflavones in Ge Gen, including daidzein, may have estrogenic activity that could affect hormonal balance during pregnancy. There is insufficient evidence regarding safety during breastfeeding. Women who are pregnant, planning pregnancy, or nursing should not use Ge Gen without explicit guidance from a qualified healthcare provider.
What is Ge Gen root used for in Traditional Chinese Medicine?
Ge Gen root is used in Traditional Chinese Medicine to release exterior conditions, raise yang qi, and generate fluids. Primary indications include neck stiffness and headache from exterior wind-cold patterns, diarrhea from damp-heat, and thirst from fluid deficiency. It is particularly valued for treating occipital headache and stiff neck, as it guides qi upward. Modern research has investigated its potential antihypertensive and cardiovascular benefits. Evidence level: C for most applications, with traditional use spanning centuries in East Asian medicine.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Ge Gen Root (Pueraria montana var. thomsonii and Pueraria lobata) is a traditional medicinal herb rich in isoflavonoids used for treating cardiovascular diseases, diabetes, and fever [PMID:21315814, PMID:35066299].
Contexte
Ge Gen (Puerariae lobatae radix) and Fen-Ge (Puerariae thomsonii radix) are dried roots of perennial leguminous vines native to South East Asia [PMID:21315814, PMID:34856076]. While often used interchangeably in traditional Chinese medicine, the Chinese Pharmacopoeia has separated them into two monographs since 2005, with Ge Gen typically containing higher levels of puerarin [PMID:21315814, PMID:34856076].
Usages traditionnels
For over 2000 years, it has been used to treat fever, acute dysentery, diarrhoea, diabetes, and cardiovascular diseases [PMID:21315814, PMID:35066299].
Composés actifs
The major constituents are isoflavonoids and triterpenoids [PMID:21315814]. Key isoflavones include puerarin (the main active component), daidzein, daidzin, genistein, and glycitein [PMID:36358493, PMID:37764353, PMID:25745227].
Mécanisme d'action
Puerarin exerts effects via the PI3K/AKT pathway to alleviate apoptosis and inflammation in kidney stone cells [PMID:39462270]. It also demonstrates antioxidant, anti-inflammatory, and neuroprotective activities [PMID:36358493, PMID:38780722]. In diabetes models, kudzu root-derived carbon dots reprogram the gut microbiota-metabolite-immune axis, increasing indole-3-carboxaldehyde (I3A) and enhancing M2-like macrophage polarization [PMID:41494302].
Puerarin shows promising cardioprotective potential in preclinical studies [PMID:41924138]
Preuve DOsteoporosis
Kudzu root is an effective medicine for treating osteoporosis, targeting the TNF signaling pathway and osteoclast differentiation [PMID:39940967]
Preuve DPrimary Dysmenorrhoea
Ge-Gen decoction (GGD) alleviated symptoms in a rat model [PMID:38594870]
Preuve DType 2 Diabetes
Kudzu root-derived carbon dots lowered fasting glucose, improved glucose tolerance and insulin sensitivity in diabetic mice [PMID:41494302]
Preuve DHIV-1
Kudzu root extract significantly inhibits HIV-1 entry into cell lines and primary human CD4+T lymphocytes by inhibiting initial viral attachment [PMID:30236131]
Preuve DHyperuricemia
Duzhong-Gegen formula reduced serum uric acid and enhanced renal uric acid excretion via SIRT1 activation in mice [PMID:41905095]
Sécurité et effets indésirables
Kudzu root extract has demonstrated hepatotoxicity in mice and HepG2 cells, evidenced by increased serum ALT, AST, and LDH leakage [PMID:26545459]. Ge Gen is listed as a herbal TCM product with potential for rare hepatotoxicity [PMID:26357619].
Interactions médicamenteuses
Pueraria root has been investigated for pharmacodynamic and pharmacokinetic interactions with rasagiline in Parkinson's disease models [PMID:41188875]. No other specific drug interactions are detailed.
Synthèse des preuves
Evidence is primarily based on preclinical animal models, in vitro studies, and systematic reviews of preclinical data. There is a lack of human clinical trial data in the provided abstracts.
Sources PubMed
1.PMID: 40714420 (2025) — Plant-derived exosomes: Unveiling the similarities and disparities between conventional extract and innovative form. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 39940967 (2025) — Network Pharmacology Analysis and Biological Validation Systemically Identified the Active Ingredients and Molecular Targets of Kudzu Root on Osteoporosis. · International journal of molecular sciences
4.PMID: 40091443 (2025) — Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury. · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Kudzu root-derived carbon dots modulate gut microbiota and metabolites for pan-organ targeted macrophage polarization in synergistic diabetes therapy.
· Biomaterials
6.PMID: 21315814 (2011) — Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. · Journal of ethnopharmacology
7.PMID: 26545459 (2015) — Evaluation of kudzu root extract-induced hepatotoxicity. · Journal of ethnopharmacology
8.PMID: 39462270 (2024) — Puerarin alleviates apoptosis and inflammation in kidney stone cells via the PI3K/AKT pathway: Network pharmacology and experimental verification. · Journal of cellular and molecular medicine
9.PMID: 26357619 (2014) — Traditional Chinese Medicine Induced Liver Injury. · Journal of clinical and translational hepatology
10.PMID: 36358493 (2022) — Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin. · Antioxidants (Basel, Switzerland)
11.PMID: 38137052 (2023) — Integrated Metabolomic and Transcriptomic Analysis of Puerarin Biosynthesis in Pueraria montana var. thomsonii at Different Growth Stages. · Genes
12.PMID: 40407304 (2025) — Daidzein alleviates CCl4- and BDL-induced liver fibrosis via suppressing the integrin alphaVbeta1/YAP signaling. · Food & function
13.PMID: 38594870 (2024) — Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model. · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
14.PMID: 42196031 (2026) — Fortification of Wheat Bread with Increasing Levels of Kudzu (Pueraria lobata) Root Powder: Technological, Nutritional, and Sensory Implications. · Foods (Basel, Switzerland)
15.PMID: 41924138 (2026) — Cardioprotective effects of puerarin against myocardial ischemia-reperfusion injury: a preclinical systematic review and meta-analysis. · Frontiers in pharmacology
16.PMID: 37764353 (2023) — Advances in Extraction, Purification, and Analysis Techniques of the Main Components of Kudzu Root: A Comprehensive Review. · Molecules (Basel, Switzerland)
17.PMID: 36704896 (2023) — Study on structural characteristics and physicochemical properties of starches extracted from three varieties of kudzu root (Pueraria lobata starch). · Journal of food science
18.PMID: 34856076 (2022) — Chloroplast genomes of two Pueraria DC. species: sequencing, comparative analysis and molecular marker development. · FEBS open bio
19.PMID: 41188875 (2025) — Interaction between rasagiline and Pueraria radix in in vitro models of parkinson's disease. · BMC complementary medicine and therapies
20.PMID: 25745227 (2015) — Thermal stability of kudzu root (Pueraria Radix) isoflavones as additives to beef patties. · Journal of food science and technology
21.PMID: 23777642 (2013) — Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA). · Journal of pharmaceutical and biomedical analysis
22.PMID: 38780722 (2024) — Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases. · Molecular neurobiology
23.PMID: 38791264 (2024) — Puerarin-A Promising Flavonoid: Biosynthesis, Extraction Methods, Analytical Techniques, and Biological Effects. · International journal of molecular sciences
24.PMID: 35066299 (2022) — Roles and mechanisms of puerarin on cardiovascular disease：A review. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
25.PMID: 18690681 (2008) — Isolation of radiolabeled isoflavones from kudzu (Pueraria lobata) root cultures. · Journal of agricultural and food chemistry
26.PMID: 38279552 (2024) — Extraction and characterisation of kudzu root residue lignin based on deep eutectic solvents. · Phytochemical analysis : PCA
27.PMID: 27717903 (2016) — An isoflavonoid-enriched extract from Pueraria lobata (kudzu) root protects human umbilical vein endothelial cells against oxidative stress induced apoptosis. · Journal of ethnopharmacology
28.PMID: 38397535 (2024) — Research Progress in Modifications, Bioactivities, and Applications of Medicine and Food Homologous Plant Starch. · Foods (Basel, Switzerland)
29.PMID: 41905095 (2026) — Duzhong-Gegen formula ameliorated hyperuricemia by enhancing renal uric acid excretion through activation of SIRT1. · Phytomedicine : international journal of phytotherapy and phytopharmacology
30.PMID: 30236131 (2018) — Potent suppression of HIV-1 cell attachment by Kudzu root extract. · Retrovirology