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Crataegus monogyna
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Le hawthorn est un arbuste ou arbre épineux dont les baies, feuilles et fleurs sont utilisés en phytothérapie européenne depuis des siècles pour la santé cardiovasculaire. C'est l'un des arbustes les mieux étudiés pour l'insuffisance cardiaque et il est approuvé par la Commission E allemande pour la diminution de la fonction cardiaque. Il est riche en flavonoïdes et en procyanidins.
Hawthorn (Crataegus spp., primarily C. laevigata and C. monogyna) has Level A evidence for chronic heart failure (NYHA I-II). Standardized leaf/flower extracts (WS 1442, LI 132) improve cardiac function, exercise tolerance, and reduce symptoms. The mechanism involves multiple cardiac effects: mild positive inotropic, coronary vasodilation, and antioxidant protection. Hawthorn is the most studied botanical for cardiovascular disease in Europe, with over 7,000 patients in clinical trials.
Flavonoids (hyperoside, vitexin, rutin), oligomeric procyanidins (OPC), and triterpenes are the primary actives. Multiple cardiac mechanisms: (1) Inhibition of phosphodiesterase-3 (PDE3), increasing cAMP and calcium availability (mild positive inotropy); (2) Coronary vasodilation via NO release; (3) ACE inhibition, reducing afterload; (4) Antioxidant protection of myocardial cells; (5) Antiarrhythmic effects. Unlike digoxin, hawthorn's effects are modest and not associated with toxicity. The multi-component nature creates synergistic cardiac benefits.
Le hawthorn est un arbuste ou arbre épineux dont les baies, feuilles et fleurs sont utilisés en phytothérapie européenne depuis des siècles pour la santé cardiovasculaire. C'est l'un des arbustes les mieux étudiés pour l'insuffisance cardiaque et il est approuvé par la Commission E allemande pour la diminution de la fonction cardiaque. Il est riche en flavonoïdes et en procyanidins.
Hawthorn (Crataegus spp., primarily C. laevigata and C. monogyna) has Level A evidence for chronic heart failure (NYHA I-II). Standardized leaf/flower extracts (WS 1442, LI 132) improve cardiac function, exercise tolerance, and reduce symptoms. The mechanism involves multiple cardiac effects: mild positive inotropic, coronary vasodilation, and antioxidant protection. Hawthorn is the most studied botanical for cardiovascular disease in Europe, with over 7,000 patients in clinical trials.
Flavonoids (hyperoside, vitexin, rutin), oligomeric procyanidins (OPC), and triterpenes are the primary actives. Multiple cardiac mechanisms: (1) Inhibition of phosphodiesterase-3 (PDE3), increasing cAMP and calcium availability (mild positive inotropy); (2) Coronary vasodilation via NO release; (3) ACE inhibition, reducing afterload; (4) Antioxidant protection of myocardial cells; (5) Antiarrhythmic effects. Unlike digoxin, hawthorn's effects are modest and not associated with toxicity. The multi-component nature creates synergistic cardiac benefits.
Hawthorn works primarily through its oligomeric procyanidins and flavonoids, which exert antioxidant and anti-inflammatory effects. These compounds dilate coronary blood vessels, improve endothelial function, and increase coronary blood flow. Evidence Level A indicates it improves cardiac muscle contractility and oxygen utilization, enhancing overall heart efficiency.
Hawthorn may potentiate the effects of cardiac glycosides (like digoxin) and blood pressure medications, potentially causing hypotension or additive effects. Because it affects heart muscle contractility, it should not be combined with beta-blockers or other heart drugs without strict medical supervision to avoid adverse reactions.
Clinical studies supporting hawthorn's efficacy typically use dosages ranging from 160 to 900 mg daily of a standardized extract. The extract should be standardized to contain approximately 18.75% oligomeric procyanidins. This daily amount is usually divided into two or three doses to maintain stable blood levels.
Hawthorn is considered unsafe during pregnancy and breastfeeding due to insufficient safety data and its potent physiological effects on the cardiovascular system. As a uterine stimulant and cardiac tonic, it poses potential risks to fetal development and pregnancy maintenance; therefore, use is strictly contraindicated without medical advice.
Hawthorn is primarily used as a cardiotonic to support cardiovascular function, specifically for mild heart failure and blood pressure regulation (Evidence Level A). Traditional uses also include aiding digestion and relieving anxiety due to its nervine properties. It improves symptoms like shortness of breath and fatigue associated with declining cardiac performance.