Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Maitake exerts its effects primarily through beta-glucans and D-fraction polysaccharides. These compounds bind to specific receptors on immune cells, such as macrophages and natural killer cells, activating them to enhance the body's immune response. This mechanism supports immune modulation and helps the body identify abnormal cells. Additionally, compounds in Maitake may improve insulin sensitivity, contributing to blood sugar regulation. Evidence Level: B.
Does Maitake interact with diabetes medications?
Yes, Maitake can interact with diabetes medications. Because Maitake naturally lowers blood glucose levels, taking it alongside insulin or oral hypoglycemic drugs may cause blood sugar to drop too low (hypoglycemia). Diabetics should monitor their blood sugar closely and consult a healthcare provider before use, as medication dosages may require adjustment. Evidence Level: B.
What is the recommended dosage for Maitake mushroom?
The standard adult dosage for Maitake is 1 to 3 grams of dried mushroom daily or 500 mg to 1 gram of extract. For targeted immune support, extracts standardized to contain D-fraction polysaccharides are often preferred. Users should follow specific product labels, as potency varies between manufacturers. Evidence Level: B.
Is Maitake mushroom safe to take during pregnancy?
Maitake is generally considered safe during pregnancy when consumed in normal food amounts. As a culinary mushroom with a long history of dietary use, it poses low risk. However, there is limited clinical data regarding high-dose medicinal extracts during pregnancy, so consulting a healthcare provider before supplementation is recommended. Evidence Level: Traditional.
Can you take Maitake if you have an autoimmune disease?
Caution is advised for individuals with autoimmune conditions. Because Maitake stimulates the immune system, it could theoretically exacerbate autoimmune symptoms by increasing immune activity. Those with conditions like lupus, rheumatoid arthritis, or multiple sclerosis should consult a qualified healthcare practitioner before use. Evidence Level: D.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Maitake (Grifola frondosa) is an edible and medicinal mushroom recognized for its nutritional properties and diverse pharmacological activities, including immunomodulatory and antitumor effects [PMID:33466429, PMID:11207456].
Contexte
Grifola frondosa, known as maitake in Japanese and hen-of-the-woods in English, is a polypore fungus characterized by overlapping caps that grows at the base of trees [PMID:31030750, PMID:33466429].
Usages traditionnels
It has been used in Eastern cultures for thousands of years and is traditionally used in Asian countries as a culinary ingredient, dietary supplement, or nutraceutical [PMID:18785781, PMID:37373268].
Composés actifs
Bioactive constituents include polysaccharides (such as the D-fraction, MD-fraction, beta-glucans, and heteroglycans), proteins, glycoproteins, sterols, phenolic compounds (including gallic acid, p-hydroxybenzoic acid, vanillic acid, caffeic acid, and p-coumaric acid), and fungal vitamin D2 [PMID:33466429, PMID:40509673, PMID:40599596, PMID:31030750].
Mécanisme d'action
Maitake exerts its effects through several mechanisms: enhancing the immune system via activation of macrophages, T cells, and natural killer (NK) cells [PMID:14977447]; acting as a PPARδ agonist to improve glucose intolerance [PMID:29873587]; down-regulating lipid metabolism enzymes such as HMGCR, ACAT2, ApoB, FAS, and ACC1 while up-regulating CYP7A1 [PMID:27536279]; and providing neuroprotective effects through neurogenesis, antioxidative, anti-inflammatory, and anti-β-amyloid activities [PMID:36749053].
Preuves cliniques
Preuve BCognitive Function in Healthy Older Adults
Continuous intake of specific maitake mushroom strains (Y10M) showed significant improvement in cognitive assessment in healthy Japanese individuals aged 60 or older [PMID:42055721]
Preuve ACancer (Preclinical)
Meta-analysis of preclinical evidence indicates that Grifola frondosa polysaccharides have significant antitumor effects [PMID:34271115]
Preuve DHyperlipidemia (Animal Models)
Administration of G. frondosa in rats markedly decreased serum cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels [PMID:27536279, PMID:9255420]
Preuve DType 2 Diabetes Mellitus (Animal Models)
G. frondosa polysaccharides reduced weight loss and hyperglycemia symptoms and regulated hepatic inflammation by modulating macrophage polarization in T2DM rats [PMID:39587947]
Preuve DColitis (Animal Models)
Maitake-fortified diets attenuated severe DSS-induced colitis in vitamin D-deficient mice [PMID:40509673]
Sécurité et effets indésirables
Maitake is reported to have beneficial therapeutic effects without significant toxicity [PMID:9110582]. In a randomized controlled trial, no participants discontinued the intervention due to adverse effects [PMID:42055721].
Synthèse des preuves
Evidence is strongest for antitumor activity in preclinical models (Meta-analysis) and cognitive improvement in healthy older adults (RCT). Much of the metabolic and anti-inflammatory evidence is derived from animal models (rats/mice).
Sources PubMed
1.PMID: 37373268 (2023) — Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. · International journal of molecular sciences
3.PMID: 36749053 (2023) — Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes), and Its Neurotrophic Properties: A Mini-Review. · International journal of medicinal mushrooms
4.PMID: 33466429 (2021) — Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake). · Foods (Basel, Switzerland)
5.PMID: 40509673 (2025) — Attenuative Effect of Grifola frondosa (Maitake Mushroom) on Severe DSS-Induced Colitis in Vitamin D-Deficient Mice. · Molecular nutrition & food research
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 35364694 (2023) — Farming of Medicinal Mushrooms. · Advances in biochemical engineering/biotechnology
7.PMID: 34271115 (2021) — Antitumor activities of Grifola frondosa (Maitake) polysaccharide: A meta-analysis based on preclinical evidence and quality assessment. · Journal of ethnopharmacology
8.PMID: 19476741 (2009) — Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration. · Journal of the Society for Integrative Oncology
9.PMID: 39587947 (2024) — Grifola frondosa Polysaccharide Ameliorates Inflammation by Regulating Macrophage Polarization of Liver in Type 2 Diabetes Mellitus Rats. · Molecular nutrition & food research
10.PMID: 37183917 (2023) — Research Themes and Trends of Hen of the Woods or Maitake Medicinal Mushroom Grifola frondosa (Agaricomycetes): A Bibliometric Analysis of the Knowledge Field. · International journal of medicinal mushrooms
12.PMID: 11207456 (2001) — Maitake extracts and their therapeutic potential. · Alternative medicine review : a journal of clinical therapeutic
13.PMID: 35282313 (2022) — A Rapid and Efficient Loop-mediated Isothermal Amplification (LAMP) Assay for the Authentication of Food Supplements Based on Maitake (Grifola Frondosa). · Food analytical methods
14.PMID: 38056754 (2024) — Grifola frondosa polysaccharides: A review on structure/activity, biosynthesis and engineering strategies. · International journal of biological macromolecules
15.PMID: 31030750 (2019) — The biological activities of the antitumor drug Grifola frondosa polysaccharide. · Progress in molecular biology and translational science
16.PMID: 32258147 (2020) — Influence of Maitake (Grifola frondosa) Particle Sizes on Human Mesenchymal Stem Cells and In Vivo Evaluation of Their Therapeutic Potential. · BioMed research international
17.PMID: 28267306 (2002) — Application of ergosterol as a maitake mushroom intake biomarker. · Annals of clinical biochemistry
18.PMID: 31679289 (2019) — Antioxidative and Immunomodulatory Activities of the Exopolysaccharides from Submerged Culture of Hen of the Woods or Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) by Addition of Rhizoma gastrodiae Extract and Its Main Components. · International journal of medicinal mushrooms
19.PMID: 40599596 (2025) — Grifola frondosa (Maitake) extract as natural antioxidant on emulsion-type pork sausages. · Food chemistry: X
20.PMID: 42055721 (2026) — Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial. · Journal of nutritional science and vitaminology
21.PMID: 27536279 (2016) — The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats. · Frontiers in microbiology
23.PMID: 14977447 (2003) — Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients. · Journal of medicinal food
24.PMID: 11349892 (2001) — Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. · Journal of nutritional science and vitaminology
25.PMID: 9255420 (1997) — Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. · Biological & pharmaceutical bulletin
26.PMID: 29873587 (2018) — Grifola frondosa (Maitake) extract activates PPARδ and improves glucose intolerance in high-fat diet-induced obese mice. · Bioscience, biotechnology, and biochemistry
27.PMID: 19228191 (2009) — Augmentation of sebaceous lipogenesis by an ethanol extract of Grifola frondosa (Maitake mushroom) in hamsters in vivo and in vitro. · Experimental dermatology
28.PMID: 18785781 (2008) — [The fungus maitake (Grifola frondosa) and its therapeutic potential]. · Revista iberoamericana de micologia