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PubMed · <i>Pfaffia paniculata</i> Extract, a Potential Antimicrobial Agent against <i>Candida</i> spp., <i>Pseudomonas aeruginosa</i>, and <i>Streptococcus mutans</i> Biofilms. (2024)
PubMed · <i>Juglans regia</i> and <i>Pfaffia paniculata</i> extracts: implications for periodontal disease treatment and correlation with Alzheimer's risk. (2025)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Pfaffia paniculata, also known as Brazilian ginseng, is an endemic Brazilian plant used traditionally for stress, inflammation, and immune support [PMID:29037916, PMID:26202807].
Contexte
Pfaffia paniculata (Amaranthaceae) is a perennial wild plant native to South America, often used as a substitute for Asian ginseng in Brazil [PMID:11091225, PMID:29607660, PMID:17030478].
Usages traditionnels
It is used in Brazilian folk medicine as an 'anti-stress' agent and for the treatment of fatigue, inflammation, low immune system, and as an aphrodisiac or antidiabetic tonic [PMID:29037916, PMID:26202807, PMID:23384553].
Composés actifs
Compounds isolated from the roots include nortriterpenoids (pfaffine A and B), ecdysteroids (ecdysone, 20-hydroxyecdysone, pterosterone, rapisterone), triterpenoids (pfaffic acid, pfameric acid, mesembryanthemoidigenic acid, oleanolic acid 28-O-beta-D-glucopyranoside), monoterpene glycosides, phytosteroids (beta-sitosterol, stigmasterol), allantoin, and saponins [PMID:19941264, PMID:14967943].
Mécanisme d'action
The herb may modulate Mapk and mucin pathways in intestinal inflammation [PMID:29037916]. In sickle cells, it appears to function as a sodium ionophore, increasing Na+ content and mean corpuscular volume to improve hydration and rheological properties [PMID:11091225]. It has also been shown to induce G2/M cell cycle arrest and caspase-3-induced apoptosis in HepG2 cells [PMID:26075002].
Preuves cliniques
Preuve BSickle Cell Disease
Extract improved red blood cell deformability in patients with SCD [PMID:26444603].
Preuve BPeriocular Hyperpigmentation
A compound cream containing P. paniculata, Ptychopetalum olacoides, and Lilium candidum showed 90% improvement in 'dark circles' [PMID:23377386, PMID:19527337].
Preuve DIntestinal Inflammation (Animal Model)
Extract at 200mg/kg significantly decreased macroscopic damage scores in TNBS-induced colonic inflammation in rats [PMID:29037916, PMID:26202807].
Preuve DCancer (Animal/In Vitro Models)
Demonstrated antineoplastic effects in Ehrlich tumors, reduced incidence of hepatic lesions in hepatocarcinogenesis models, and cytotoxicity in MCF-7 breast cancer cells [PMID:14623028, PMID:16051424, PMID:16039950, PMID:18485683].
Preuve DSexual Performance (Animal Model)
Fluid extracts improved copulatory performance in sexually sluggish or impotent male rats [PMID:10227074].
Preuve D
Sécurité et effets indésirables
In animal studies, doses up to 1000mg/kg did not cause weight loss or histopathological alterations in the liver, kidney, or spleen [PMID:17481871, PMID:14623028]. However, a case of occupational asthma was reported in a patient exposed to P. paniculata root powder during capsule manufacturing [PMID:1955631].
Synthèse des preuves
The majority of evidence is derived from in vitro studies and animal models (Level D), with limited clinical evidence (Level B) regarding sickle cell red blood cell deformability and cosmetic use for periorbital hyperpigmentation.
Sources PubMed
1.PMID: 29037916 (2018) — Pfaffia paniculata (Brazilian ginseng) extract modulates Mapk and mucin pathways in intestinal inflammation. · Journal of ethnopharmacology
2.PMID: 26202807 (2015) — Anti-inflammatory effects of Brazilian ginseng (Pfaffia paniculata) on TNBS-induced intestinal inflammation: Experimental evidence. · International immunopharmacology
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Extracts showed antimicrobial activity against Candida spp., S. mutans, P. aeruginosa, K. pneumoniae, and oral pathogens P. endodontalis and P. gingivalis [PMID:38930547, PMID:28004034, PMID:36057926, PMID:40453709].
· Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
6.PMID: 16214177 (2006) — Effects of Pfaffia paniculata (Brazilian ginseng) extract on macrophage activity. · Life sciences
7.PMID: 40453709 (2025) — Juglans regia and Pfaffia paniculata extracts: implications for periodontal disease treatment and correlation with Alzheimer's risk. · Frontiers in cellular and infection microbiology
8.PMID: 14623028 (2003) — Effect of Pfaffia paniculata (Brazilian ginseng) on the Ehrlich tumor in its ascitic form. · Life sciences
9.PMID: 19427770 (2010) — Pfaffia paniculata (Brazilian ginseng) roots decrease proliferation and increase apoptosis but do not affect cell communication in murine hepatocarcinogenesis. · Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
10.PMID: 16039950 (2005) — Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model. · Cancer letters
11.PMID: 10917139 (2000) — Effects of oral administration of Pfaffia paniculata (Brazilian ginseng) on incidence of spontaneous leukemia in AKR/J mice. · Cancer detection and prevention
12.PMID: 38930547 (2024) — Pfaffia paniculata Extract, a Potential Antimicrobial Agent against Candida spp., Pseudomonas aeruginosa, and Streptococcus mutans Biofilms. · Microorganisms
13.PMID: 40574006 (2025) — Exploring Antioxidant, Antimicrobial and Anti-Inflammatory Effects of Juglans regia and Pfaffia paniculata Extracts: Implications for Intestinal Dysbiosis and Colorectal Cancer Risk Associated with Oral Pathogens. · Pharmaceutics
14.PMID: 14967943 (2003) — Pfaffia paniculata-induced changes in plasma estradiol-17beta, progesterone and testosterone levels in mice. · The Journal of reproduction and development
15.PMID: 18485683 (2009) — Cytotoxic effects of butanolic extract from Pfaffia paniculata (Brazilian ginseng) on cultured human breast cancer cell line MCF-7. · Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
16.PMID: 23377386 (2013) — Periocular hyperpigmentation: a review of etiology and current treatment options. · Journal of drugs in dermatology : JDD
17.PMID: 26444603 (2015) — Pfaffia paniculata extract improves red blood cell deformability in sickle cell patients. · Clinical hemorheology and microcirculation
18.PMID: 29607660 (2019) — Two new triterpenes from the roots of Pfaffia glomerata. · Journal of Asian natural products research
19.PMID: 17030478 (2007) — Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in Brazil. · Journal of ethnopharmacology
20.PMID: 42180249 (2026) — Correction: Juglans regia and Pfaffia paniculata extracts: implications for periodontal disease treatment and correlation with Alzheimer's risk. · Frontiers in cellular and infection microbiology
21.PMID: 36057926 (2023) — Antimicrobial action of four herbal plants over mixed-species biofilms of Candida albicans with four different microorganisms. · Australian endodontic journal : the journal of the Australian Society of Endodontology Inc
22.PMID: 16051424 (2006) — Antineoplastic effects of butanolic residue of Pfaffia paniculata. · Cancer letters
23.PMID: 10227074 (1999) — Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual-behavior of male rats. · Psychopharmacology
24.PMID: 1955631 (1991) — Occupational asthma caused by Brazil ginseng dust. · The Journal of allergy and clinical immunology
25.PMID: 28004034 (2016) — Klebsiella pneumoniae Planktonic and Biofilm Reduction by Different Plant Extracts: In Vitro Study. · TheScientificWorldJournal
26.PMID: 11091225 (2000) — Hydration of sickle erythrocytes using a herbal extract (Pfaffia paniculata) in vitro. · British journal of haematology
27.PMID: 15784959 (2005) — Characterization of hypoglycemiant plants by total reflection X-ray fluorescence spectrometry. · Biological trace element research
28.PMID: 23384553 (2013) — Development of an analytical method for the quantification of pfaffic acid in Brazilian ginseng (Hebanthe eriantha). · Journal of pharmaceutical and biomedical analysis
29.PMID: 26075002 (2015) — Pfaffosidic Fraction from Hebanthe paniculata Induces Cell Cycle Arrest and Caspase-3-Induced Apoptosis in HepG2 Cells. · Evidence-based complementary and alternative medicine : eCAM
30.PMID: 19527337 (2009) — Effects of a Brazilian herbal compound as a cosmetic eyecare for periorbital hyperchromia ("dark circles"). · Journal of cosmetic dermatology