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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Pluchea indica exerts anti-inflammatory effects primarily through its volatile oil constituents, including beta-caryophyllene, camphor, borneol, and limonene. Beta-caryophyllene acts as a selective CB2 cannabinoid receptor agonist, which modulates inflammatory pathways without psychoactive effects. The herb also contains plucheine, a unique alkaloid with demonstrated anti-inflammatory activity in preliminary research. These compounds work synergistically to inhibit pro-inflammatory mediators and reduce oxidative stress. Evidence level: C (preclinical and traditional use).
Does Pluchea indica interact with any medications?
Limited clinical data exists on Pluchea indica drug interactions. Due to its diuretic properties, it may potentiate the effects of pharmaceutical diuretics and affect electrolyte balance. Its anti-inflammatory compounds could theoretically interact with NSAIDs or anticoagulant medications, though specific interactions have not been documented in clinical trials. Patients taking medications for kidney conditions should avoid this herb due to potential nephrotoxic effects. Consult a healthcare provider before combining with prescription medications. Evidence level: C.
What is the recommended dosage for Pluchea indica?
Traditional adult dosages for Pluchea indica are 5-10 grams of fresh leaves or 3-6 grams of dried herb daily, typically prepared as a decoction or infusion. Standardized extracts lack established dosing guidelines due to insufficient clinical research. Dosage should be adjusted based on individual tolerance and the specific condition being addressed. Start with lower doses to assess tolerance. These recommendations are based on traditional use rather than clinical trials. Evidence level: C.
Is Pluchea indica safe to take during pregnancy?
Pluchea indica is contraindicated during pregnancy and should be avoided. The herb contains volatile oils including camphor and borneol, which may stimulate uterine contractions or cause fetal toxicity at therapeutic doses. Traditional use data and the presence of these bioactive compounds indicate potential risks to fetal development. Women who are pregnant, planning to become pregnant, or breastfeeding should not use Pluchea indica medicinally. Food-amount consumption in small quantities is generally considered safe. Evidence level: C.
What is Pluchea indica used for in traditional medicine?
Pluchea indica has been used traditionally in Southeast Asian and South Asian medicine for digestive disorders including indigestion, bloating, and stomach discomfort. It is employed as an anti-inflammatory agent for rheumatism and joint pain, and as a diuretic to promote urine flow and reduce fluid retention. The herb is also applied topically for skin conditions and wound healing in some traditional systems. These uses are supported by ethnobotanical records and preliminary pharmacological studies. Evidence level: C.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Pluchea indica, also known as Indian camphorweed, is a medicinal plant used in traditional medicine for its nutritional and pharmacological benefits [PMID:35458586]. It is recognized for its anti-infective, antioxidant, and anti-inflammatory properties [PMID:37944874, PMID:32742373].
Contexte
Pluchea indica (L.) Less. is a member of the Asteraceae family, commonly referred to as Indian camphorweed, pluchea, or marsh fleabane [PMID:35458586]. It is a wide-distributed species of mangrove associate plant found in regions including Asia and northern Australia [PMID:33474035, PMID:30214836].
Usages traditionnels
It is utilized in traditional medicine to treat a wide range of conditions, including diabetes, rheumatism, lumbago, kidney stones, leucorrhea, inflammation, gangrenous and atonic ulcers, hemorrhoids, dysentery, eye diseases, itchy skin, acid stomach, dysuria, abdominal pain, scabies, and fever [PMID:35458586]. It is also used as a medicinal vegetable and consumed as herbal tea [PMID:37944874, PMID:37402936].
Composés actifs
The plant contains a variety of biomolecules, including thiophenes, terpenes, quinic acids, sterols, lignans, phenolics, and flavonoids [PMID:35458586, PMID:31370202]. Specific leaf extract analysis has identified phenolics (90.25 mg/g DW), flavonoids (275.53 mg/g DW), and tannins (26.45 mg/g DW) [PMID:38274007].
Mécanisme d'action
In nasopharyngeal carcinoma cells, root extracts induce apoptosis by up-regulating pro-apoptotic Bax protein and p53 protein while down-regulating anti-apoptotic Bcl-2 protein [PMID:26111179]. In rats with high fat-high fructose diets, leaf extract modifies the expression of lipid metabolism-related genes to alleviate dyslipidemia and hepatic steatosis [PMID:36721751].
Preuves cliniques
Preuve DDiabetes-induced liver injury
Leaf ethanol extract mitigated liver injury, oxidative stress, and inflammation in streptozotocin-induced diabetic mice [PMID:32742373]
Preuve DDyslipidemia and Hepatic Steatosis
Leaf extract (100 or 300 mg/kg/d) significantly improved lipid profiles and reduced hepatic triglyceride content in rats fed a high fat-high fructose diet [PMID:36721751]
Preuve DOral Candidiasis
Ethanolic extract showed antifungal activity against Candida albicans in vitro, with MIC ranging from 50 to 200 mg/mL [PMID:34937105]
Preuve DNasopharyngeal Carcinoma
Root extracts inhibited viability and migration of human nasopharyngeal carcinoma cells and increased apoptosis [PMID:26111179]
Preuve DCutaneous and Oral Wound Healing
Branch extract nanoparticles increased proliferation and migration of primary epidermal keratinocytes and human dermal fibroblasts [PMID:35163900]
Sécurité et effets indésirables
Stigmasterol extracted from P. indica leaves was found to reduce spermatogenesis and alter sperm morphology in male rats [PMID:42281658].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating potential anti-inflammatory, antimicrobial, and metabolic benefits, though human clinical trials are lacking.
Sources PubMed
1.PMID: 35458586 (2022) — Phytoconstituents and Pharmacological Activities of Indian Camphorweed (Pluchea indica): A Multi-Potential Medicinal Plant of Nutritional and Ethnomedicinal Importance. · Molecules (Basel, Switzerland)
2.PMID: 37402936 (2023) — Toxicity, physiological, and morphological alterations of Indian camphorweed (Pluchea indica) in response to excess copper. · Environmental geochemistry and health
3.PMID: 37944874 (2024) — Insights into the anti-infective effects of Pluchea indica (L.) Less and its bioactive metabolites against various bacteria, fungi, viruses, and parasites. · Journal of ethnopharmacology
4.PMID: 34937105 (2022) — Antifungal Activity of Beluntas "Indian Camphorweed" (Pluchea indica) Ethanol Extract on Candida albicans In Vitro Using Different Solvent Concentrations. · European journal of dentistry
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Green biosynthesis of bimetallic selenium-gold nanoparticles using Pluchea indica leaves and their biological applications.
· Frontiers in bioengineering and biotechnology
6.PMID: 35163900 (2022) — Phytochemical Analysis, Antioxidant, and Wound Healing Activity of Pluchea indica L. (Less) Branch Extract Nanoparticles. · Molecules (Basel, Switzerland)
7.PMID: 38041881 (2023) — Optimization of Pluchea indica (L.) leaf extract using ultrasound-assisted extraction and its cytotoxicity on the HT-29 colorectal cancer cell line. · Ultrasonics sonochemistry
8.PMID: 33474035 (2017) — Complete chloroplast genome of Pluchea indica (L.) Less. (Asteraceae) and its phylogenetic analysis. · Mitochondrial DNA. Part B, Resources
9.PMID: 32742373 (2020) — Treatment with Pluchea indica (L.) Less. leaf ethanol extract alleviates liver injury in multiple low-dose streptozotocin-induced diabetic BALB/c mice. · Experimental and therapeutic medicine
10.PMID: 36721751 (2022) — Pluchea indica Leaf Extract Alleviates Dyslipidemia and Hepatic Steatosis by Modifying the Expression of Lipid Metabolism-Related Genes in Rats Fed a High Fat-High Fructose Diet. · Preventive nutrition and food science
11.PMID: 39129835 (2024) — Computational and in vitro analyses of the antibacterial effect of the ethanolic extract of Pluchea indica L. leaves. · Biomedical reports
12.PMID: 30134639 (2018) — Bioactive Constituents from the Aerial Parts of Pluchea indica Less. · Molecules (Basel, Switzerland)
13.PMID: 42281658 (2026) — Stigmasterol from Pluchea indica Leaves Reduces Spermatogenesis and Alters Sperm Morphology in Male Rat: In Vivo and In Silico Study. · F1000Research
14.PMID: 26111179 (2015) — Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells. · Molecules (Basel, Switzerland)
15.PMID: 30214836 (2018) — Development of EST-SSR markers for Pluchea indica (Asteraceae) and cross-amplification in related species. · Applications in plant sciences
16.PMID: 31370202 (2019) — Comprehensive Chemical Profiling in the Ethanol Extract of Pluchea indica Aerial Parts by Liquid Chromatography/Mass Spectrometry Analysis of Its Silica Gel Column Chromatography Fractions. · Molecules (Basel, Switzerland)