Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
⚠️ Non recommandé pendant la grossesse ou l'allaitement
Cette plante n'est PAS recommandée pendant la grossesse en raison de risques potentiels pour le fœtus en développement.
Cette plante n'est PAS recommandée pendant l'allaitement car les effets sur les nourrissons sont inconnus.
Consultez votre professionnel de santé avant l'utilisation.
2 interactions médicamenteuses connues — Certaines peuvent être graves
2 Modéré
Cette plante peut interagir avec les médicaments que vous prenez. Consultez le tableau des interactions ci-dessous et parlez-en à votre professionnel de santé avant l'utilisation.
Qu'est-ce qu'une interaction plante-médicament ?
Une interaction plante-médicament se produit lorsqu'une plante ou un complément modifie l'action d'un médicament dans votre organisme — en le rendant plus puissant, moins efficace, ou plus susceptible de provoquer des effets nocifs. Les plantes contiennent des composés actifs qui peuvent accélérer ou ralentir les enzymes et transporteurs utilisés pour métaboliser les médicaments.
Pourquoi c'est important
•Millepertuis peut rendre la contraception, les antidépresseurs et les anticoagulants moins efficaces.
•Ail peut augmenter le risque de saignement avec la warfarine et autres anticoagulants (aussi ginkgo, gingembre et curcuma).
•Kava peut amplifier la sédation avec les médicaments contre l'anxiété ou le sommeil (aussi la valériane).
Le risque est plus élevé chez les personnes âgées, ceux qui prennent plusieurs médicaments et les personnes atteintes de maladies chroniques.
Indiquez toujours à votre médecin et à votre pharmacien toutes les plantes et compléments que vous prenez — et vérifiez ci-dessous avant toute association.
La schisandra pourrait augmenter les niveaux de tacrolimus par inhibition enzymatique.
Cette liste reflète un sous-ensemble sélectionné d'interactions documentées et n'est pas exhaustive. L'absence d'un médicament ici ne prouve pas qu'il est sans danger à combiner. Confirmez toujours auprès d'un pharmacien ou d'un professionnel de santé.
Schisandra contains active lignans, such as schisandrin and gomisin A, which function as adaptogens. These compounds are believed to regulate the hypothalamic-pituitary-adrenal (HPA) axis, helping the body resist stress. Additionally, Schisandra lignans induce liver detoxification enzymes and provide antioxidant protection to hepatocytes, supporting liver health. This mechanism supports its traditional use for enhancing endurance and mental clarity (Evidence Level C/Traditional).
Does Schisandra interact with prescription medications?
Yes, Schisandra has significant potential for drug interactions. It affects the cytochrome P450 enzyme system (specifically CYP3A4 and CYP2C19), which metabolizes many pharmaceuticals. This interaction can alter the breakdown of drugs, potentially increasing side effects or reducing efficacy. Patients taking anticoagulants, immunosuppressants, or drugs metabolized by the liver should consult a physician before use to avoid adverse interactions.
What is the recommended daily dosage for Schisandra?
For general health support, the typical adult dosage is 500 to 2000mg of dried Schisandra berries daily. For standardized extracts, a dosage of 250 to 500mg daily is common. It is often taken to support liver function or improve physical endurance. Because Schisandra can increase stomach acid, it is best taken with food to minimize gastrointestinal discomfort (Evidence Level C).
Is Schisandra safe to take during pregnancy?
No, Schisandra is considered unsafe during pregnancy. It is a uterine stimulant and may cause uterine contractions, increasing the risk of miscarriage or premature labor. Consequently, pregnant women should strictly avoid Schisandra supplements. Breastfeeding women should also avoid it due to a lack of safety data. This herb is contraindicated for individuals with epilepsy or high intracranial pressure as well.
What are the common side effects of taking Schisandra?
While generally safe for healthy adults, Schisandra can cause side effects in some individuals. Common complaints include gastrointestinal upset, heartburn, and decreased appetite. Because it stimulates gastric acid secretion, it is contraindicated for people with GERD or peptic ulcers. Other potential side effects include skin rash and allergic reactions. Discontinue use if you experience itching, swelling, or difficulty breathing.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Schisandra chinensis is a traditional Chinese medicinal herb recognized as a plant adaptogen used to enhance the body's resistance to stress and stability against physical loads [PMID:34445021, PMID:38398618].
Contexte
Schisandra chinensis (also known as Wu Wei Zi or Bei-Wuweizi) is a member of the Magnoliaceae family [PMID:39454375, PMID:18849034]. It is used as both a medicine and a food ingredient in China, Korea, Russia, and Japan [PMID:35359848, PMID:34678416, PMID:29352909].
Usages traditionnels
Traditionally used to treat coughs, insomnia, dreaminess, palpitation, spermatorrhea, and disorders of the liver and kidney [PMID:34678416, PMID:37001770]. It is also used to tonify Qi, nourish the kidney, calm the heart, and produce fluid to relieve mental stress [PMID:37001770, PMID:38336330].
Composés actifs
The primary bioactive compounds are dibenzocyclooctadiene lignans (such as schisandrin, schisandrin B, schisantherin A, schisantherin B, schisanhenol, deoxyschisandrin, and gomisin A) [PMID:36771299, PMID:31431019]. Other active components include polysaccharides (composed of glucose, mannose, rhamnose, galactose, galacturonic acid, and arabinose), flavonoids, phenolic acids, anthocyanins, triterpenes, and norsesquiterpenoids [PMID:38788881, PMID:37560060, PMID:35347956].
Mécanisme d'action
Mechanisms include the reduction of CYP2E1-dependent oxidative stress [PMID:29902864], activation of the cGAS-STING pathway to inhibit HBV replication [PMID:37001770], and regulation of hepatic ceramide homeostasis via ASAH1 [PMID:41207267]. It also acts by fortifying mitochondrial antioxidant status [PMID:16552829], suppressing neuroinflammation through TRPV1 expression in microglia [PMID:39454375], and activating the pregnane X receptor (PXR) to induce drug-metabolizing enzymes [PMID:16267138].
Preuves cliniques
Preuve ALiver Injury
Bioactive compounds significantly reduced alanine aminotransferase (ALT) levels and exhibit hepatoprotective, antioxidant, and anti-inflammatory effects [PMID:40832608].
Preuve DMetabolic Steatohepatitis (MASH)
Lignan extracts (SLE) and polysaccharides (SCP) effectively reversed steatosis and reduced serum transaminase levels and pro-inflammatory cytokines in mouse models [PMID:41207267].
Preuve DParkinson's Disease
Lignan-enriched extracts (LSC) addressed neuroinflammation and behavioral changes in MPTP-treated mice [PMID:39454375].
Preuve DColitis-induced Depression
Vinegar-processed Schisandra Chinensis (VSC) enhanced therapeutic effects on depressive behavior in chronic UC mice [PMID:39357281].
Preuve DDiabetic Skin Wound Healing
The active component Gomisin A demonstrated effectiveness in treating diabetic skin wounds in obese mice models [PMID:39303965].
Preuve D
Interactions médicamenteuses
Schisandra lignans may induce metabolic drug-drug interactions (DDIs) by inhibiting cytochrome P450 and P-glycoprotein activities [PMID:35359848]. It has been shown to activate the pregnane X receptor (PXR), increasing the clearance of warfarin in rats [PMID:16267138].
Synthèse des preuves
The evidence is primarily based on preclinical animal models (D) and literature reviews (C), with one systematic review and meta-analysis (A) supporting its hepatoprotective effects.
2.PMID: 38398618 (2024) — Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review. · Molecules (Basel, Switzerland)
3.PMID: 39357281 (2024) — Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism. · Phytomedicine : international journal of phytotherapy and phytopharmacology
4.PMID: 29902864 (2018) — Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative stress. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
5.PMID: 39885030 (2025) — Identification of Lignans. · Methods in molecular biology (Clifton, N.J.)
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Combination of Schisandra and Evodia herbs improved learning and memory impairment in AD model rats [PMID:37787050].
6.PMID: 31431019 (2019) — Schisandra chinensis and its phytotherapeutical applications. · Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti
7.PMID: 35359848 (2022) — A Comprehensive Review of the Main Lignan Components of Schisandra chinensis (North Wu Wei Zi) and Schisandra sphenanthera (South Wu Wei Zi) and the Lignan-Induced Drug-Drug Interactions Based on the Inhibition of Cytochrome P450 and P-Glycoprotein Activities. · Frontiers in pharmacology
8.PMID: 39454375 (2024) — Lignans of Schisandra chinensis (Turcz.) Baill inhibits Parkinson's disease progression through mediated neuroinflammation-TRPV1 expression in microglia. · Phytomedicine : international journal of phytotherapy and phytopharmacology
9.PMID: 29352909 (2018) — A review of polysaccharides from Schisandra chinensis and Schisandra sphenanthera: Properties, functions and applications. · Carbohydrate polymers
10.PMID: 18849034 (2009) — Analysis of Schisandra chinensis and Schisandra sphenanthera. · Journal of chromatography. A
11.PMID: 33919588 (2021) — Antioxidant Effects of Schisandra chinensis Fruits and Their Active Constituents. · Antioxidants (Basel, Switzerland)
12.PMID: 41207267 (2025) — Schisandra chinensis lignans and polysaccharides alleviate MASH via ASAH1-mediated regulation of hepatic ceramide homeostasis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
13.PMID: 38542438 (2024) — Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. · International journal of molecular sciences
14.PMID: 40832608 (2025) — Efficacy of Schisandra chinensis in liver injury: a systematic review and preclinical meta-analysis. · Frontiers in pharmacology
15.PMID: 36771299 (2023) — Cardioprotective Potential of Berries of Schisandra chinensis Turcz. (Baill.), Their Components and Food Products. · Nutrients
16.PMID: 16552829 (2006) — Biochemical basis of the "Qi-invigorating" action of Schisandra berry (wu-wei-zi) in Chinese medicine. · The American journal of Chinese medicine
17.PMID: 34678416 (2022) — A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils. · Journal of ethnopharmacology
18.PMID: 37560060 (2023) — An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology. · Frontiers in nutrition
19.PMID: 23538076 (2013) — Adaptogens in mental and behavioral disorders. · The Psychiatric clinics of North America
20.PMID: 29986408 (2018) — Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases. · International journal of molecular sciences
21.PMID: 40974027 (2025) — Microglia-Derived Cell Membranes Encapsulated Schisandra chinensis Polysaccharide-Zinc Complex for the Treatment of Spinal Cord Injury. · ACS applied materials & interfaces
22.PMID: 40205412 (2025) — A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment. · Chinese medicine
23.PMID: 37001770 (2023) — Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication. · Journal of ethnopharmacology
24.PMID: 16267138 (2006) — Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. · The Journal of pharmacology and experimental therapeutics
25.PMID: 22039930 (2012) — Panax ginseng, Rhodiola rosea and Schisandra chinensis. · International journal of food sciences and nutrition
26.PMID: 38336330 (2024) — The extraction, purification, structural features, bioactivities, and applications of Schisandra chinensis polysaccharides: A review. · International journal of biological macromolecules
27.PMID: 38788881 (2024) — Extraction, purification, structural characterization, and biological activity of polysaccharides from Schisandra chinensis: A review. · International journal of biological macromolecules
28.PMID: 37787050 (2023) — Different ratios of Schisandra chinensis and Evodia rutaecarpa combination for treating Alzheimer's disease. · Experimental biology and medicine (Maywood, N.J.)
29.PMID: 39303965 (2025) — Efficacy and mechanism of Schisandra chinensis active component Gomisin A on diabetic skin wound healing: network pharmacology and in vivo experimental validation. · Journal of ethnopharmacology
30.PMID: 35347956 (2022) — [A new norsesquiterpenoid from Schisandra chinensis]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica