Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Strobilanthes crispus work to treat kidney stones?
Strobilanthes crispus exerts its effects primarily through diuretic and anti-lithic properties. The plant contains high levels of potassium and silicic acid, which help increase urine output, potentially flushing out small stones and preventing new crystal formation. Additionally, the flavonoids and glucosides present act as antioxidants, protecting renal tissues from oxidative damage. While these mechanisms are supported by traditional use and preliminary phytochemical analysis, clinical trials are limited, giving it an Evidence Level C.
Is Strobilanthes crispus safe to consume during pregnancy?
No, Strobilanthes crispus is considered unsafe during pregnancy. Traditional medicinal texts and available pharmacological data contraindicate its use for expectant mothers because the herb can stimulate uterine contractions or alter fluid balance. Due to insufficient safety data and potential risks to fetal development, women who are pregnant or breastfeeding should avoid this herb entirely. It is crucial to consult a qualified healthcare provider before using any herbal supplements during pregnancy.
What is the recommended dosage for Strobilanthes crispus tea?
The standard adult dosage for Strobilanthes crispus is 3 to 5 grams of dried leaves prepared as a tea, taken up to three times daily. This preparation is traditionally used to support kidney health and manage blood sugar levels. Users should not exceed this recommended amount, as excessive intake can lead to side effects such as nausea or electrolyte imbalances. Dosage recommendations are based on traditional use (Evidence Level C) rather than standardized clinical trials.
Does Strobilanthes crispus interact with blood pressure or diabetes medications?
Yes, Strobilanthes crispus has potential interactions with antihypertensive and antidiabetic drugs. Because the herb acts as a diuretic and may lower blood glucose, taking it alongside prescription diuretics or diabetes medications could potentiate effects, leading to hypotension or hypoglycemia. Patients managing hypertension or diabetes should monitor their levels closely and consult a physician before adding this herb to their regimen to avoid adverse interactions (Evidence Level C).
Can Strobilanthes crispus help lower high blood pressure?
Strobilanthes crispus is traditionally used to treat hypertension, primarily due to its diuretic action. By increasing urine production, the herb helps reduce blood volume, which can subsequently lower blood pressure. The presence of potassium and specific flavonoids supports cardiovascular health. However, while animal studies suggest a benefit, there is a lack of robust human clinical trials to confirm efficacy. Therefore, it should not replace prescribed antihypertensive medication without medical supervision (Evidence Level C).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Strobilanthes crispus is a medicinal herb native to Malaysia and the Malay Archipelago, traditionally used for cancer, diabetes, and immune system support [PMID:36046107, PMID:33127562, PMID:20684795].
Contexte
Strobilanthes crispus (Acanthaceae family), also known as Batuzin, Bayam Karang, Kotz Bellin, Pekka Batu, Pecah kaca, or Jin batu, is a plant native to Malaysia [PMID:36046107, PMID:30594607, PMID:33127562].
Usages traditionnels
Traditionally used for the treatment of cancer, gastrointestinal disorders, inflammatory wounds of snake bites, kidney stones, diabetes, hypertension, and to boost the immune system [PMID:30594607, PMID:33127562, PMID:29100935, PMID:27844243]. It has also been used as a diuretic, antilytic, and laxative [PMID:16688478, PMID:22471785].
Composés actifs
Identified constituents include lutein, β-sitosterol, and stigmasterol [PMID:33127562, PMID:33906591]. Other reported metabolites include indolo-quinazoline alkaloids, flavonoids, phenolic acids, sterols, terpenoids, tannins, caffeine, and α-linolenic acid [PMID:42005722, PMID:11137889, PMID:30970652].
Mécanisme d'action
The herb's bioactive subfraction F3 inhibits breast cancer metastasis by affecting markers such as E-cadherin, MMP-9, MUC-1, N-cadherin, Twist, VEGF, and vimentin [PMID:30594607]. It exhibits anti-glycolytic activity by inhibiting the localization of GLUT1 to the cell membrane via reduction in PKC activity and increased TXNIP protein expression [PMID:37259304]. It may induce apoptosis through the mitochondria-dependent p53 pathway [PMID:22471785] or by suppressing BCL-2 protein expression [PMID:33511882]. Additionally, it stimulates anti-tumor immunogenicity by increasing MHC class I and II molecules and infiltrating CD4+, CD8+, and IL-2+ cells into the tumor microenvironment [PMID:35972917].
Preuves cliniques
Preuve DBreast Cancer
Bioactive subfraction F3 inhibited tumor progression, migration, and metastasis in 4T1-induced mouse mammary carcinoma models [PMID:30594607, PMID:33127562].
Preuve DColon Cancer
Ethanol extract significantly inhibited colorectal carcinogenesis and reduced aberrant crypt foci (ACF) in rats [PMID:26307342, PMID:26608653].
Preuve DHyperglycemia
Hot water extracts of fermented and unfermented tea reduced blood glucose in streptozotocin-induced hyperglycemic rats [PMID:16688478].
Preuve DHepatocellular Carcinoma
Juice concentrations above 0.1% induced apoptosis and DNA damage in HepG2 cell lines [PMID:26320494].
Sécurité et effets indésirables
A 14-day subacute oral toxicity study in rats using ethanol leaf extracts (up to 600 mg/kg) did not cause significant changes in body weight, food consumption, or liver and kidney function parameters [PMID:23593574].
Interactions médicamenteuses
The bioactive subfraction F3 exhibited relatively weak inhibition of CYP2B6, CYP2C19, CYP2D6, and CYP3A4 enzymes [PMID:35146636].
Synthèse des preuves
The current evidence is primarily based on in vitro cell lines and in vivo animal models (predominantly rats and mice), indicating promising anticancer, antihyperglycemic, and antioxidant properties; however, there are no human clinical trials provided.
Sources PubMed
1.PMID: 36046107 (2022) — The complete chloroplast genome of Strobilanthes crispus (Acanthaceae). · Mitochondrial DNA. Part B, Resources
2.PMID: 30594607 (2019) — Strobilanthes crispus inhibits migration, invasion and metastasis in breast cancer. · Journal of ethnopharmacology
3.PMID: 33127562 (2021) — Strobilanthes crispus bioactive subfraction inhibits tumor progression and improves hematological and morphological parameters in mouse mammary carcinoma model. · Journal of ethnopharmacology
4.PMID: 35972917 (2022) — Strobilanthes crispus elicits anti-tumor immunogenicity in in vitro and in vivo metastatic breast carcinoma. · PloS one
5.PMID: 42005722 (2026) — Advances on Ethnobotanical, Phytochemical, and Preclinical Studies of Strobilanthes crispus and Strobilanthes cusia (Acanthaceae) for Drug Development Purpose: A Narrative Review.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 35268823 (2022) — Wound Healing, Antimicrobial and Antioxidant Properties of Clinacanthus nutans (Burm.f.) Lindau and Strobilanthes crispus (L.) Blume Extracts. · Molecules (Basel, Switzerland)
7.PMID: 33906591 (2022) — Antiglycolytic Activities of Strobilanthes crispus Active Fraction and its Bioactive Components on Triple-Negative Breast Cancer Cells In Vitro. · Anti-cancer agents in medicinal chemistry
8.PMID: 37847252 (2023) — Green synthesis, characterisation and antibacterial activities of Strobilanthes crispus-mediated silver nanoparticles (SC-AGNPS) against selected bacteria. · Artificial cells, nanomedicine, and biotechnology
9.PMID: 33511882 (2022) — Stem Hexane Extract of Strobilanthes crispus Induces Apoptosis in Triple-Negative Breast Cancer Cell Line. · Nutrition and cancer
10.PMID: 35146636 (2022) — Inhibition of Cytochrome P450s by Strobilanthes crispus Sub-Fraction (F3): Implication for Herb-Drug Interaction. · European journal of drug metabolism and pharmacokinetics
11.PMID: 20376534 (2010) — Strobilanthes crispus attenuates renal carcinogen, iron nitrilotriacetate (Fe-NTA)-mediated oxidative damage of lipids and DNA. · Molecular and cellular biochemistry
12.PMID: 37259304 (2023) — Regulatory Mechanism on Anti-Glycolytic and Anti-Metastatic Activities Induced by Strobilanthes crispus in Breast Cancer, In Vitro. · Pharmaceuticals (Basel, Switzerland)
13.PMID: 30914878 (2018) — Strobilanthes crispus Extract Reduces Respiratory Exchange Ratio in Obese Mice Fed High Fat and Low Fat Diets. · The Malaysian journal of medical sciences : MJMS
14.PMID: 26608653 (2015) — Evaluation of chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in vivo. · BMC complementary and alternative medicine
15.PMID: 26307342 (2015) — Chemopreventive effects of Strobilanthes crispus leaf extract on azoxymethane-induced aberrant crypt foci in rat colon. · Scientific reports
16.PMID: 29100935 (2018) — Immunomodulatory effects of a bioactive fraction of Strobilanthes crispus in NMU-induced rat mammary tumor model. · Journal of ethnopharmacology
17.PMID: 37561949 (2023) — Optimization of total phenolic content, total flavonoid content and anti-gout properties of polyherbal formulation. · Journal of complementary & integrative medicine
18.PMID: 30970652 (2019) — Antioxidant Activity, and Volatile and Phytosterol Contents of Strobilanthes crispus Dehydrated Using Conventional and Vacuum Microwave Drying Methods. · Molecules (Basel, Switzerland)
19.PMID: 23593574 (2012) — Subacute oral toxicity study of ethanolic leaves extracts of Strobilanthes crispus in rats. · Asian Pacific journal of tropical biomedicine
20.PMID: 20112179 (2010) — Anti-angiogenic and cytotoxicity studies of some medicinal plants. · Planta medica
21.PMID: 26320494 (2015) — Strobilanthes crispus Juice Concentrations and Anticancer Effects on DNA Damage, Apoptosis and Gene Expression in Hepatocellular Carcinoma Cells. · Asian Pacific journal of cancer prevention : APJCP
22.PMID: 16688478 (2006) — Effects of Strobilanthes crispus tea aqueous extracts on glucose and lipid profile in normal and streptozotocin-induced hyperglycemic rats. · Plant foods for human nutrition (Dordrecht, Netherlands)
23.PMID: 11137889 (2000) — Chemical composition and antioxidant activity of Strobilanthes crispus leaf extract. · The Journal of nutritional biochemistry
24.PMID: 24862048 (2014) — Antitrypanosomal screening and cytotoxic effects of selected medicinal plants. · Tropical biomedicine
25.PMID: 26613959 (2015) — Phytochemical constituents and biological activities of different extracts of Strobilanthes crispus (L.) Bremek leaves grown in different locations of Malaysia. · BMC complementary and alternative medicine
26.PMID: 23022321 (2012) — Hypoxia affects cellular responses to plant extracts. · Journal of ethnopharmacology
27.PMID: 25058874 (2014) — Ethnobotanical survey of usage of fresh medicinal plants in Singapore. · Journal of ethnopharmacology
28.PMID: 27844243 (2017) — Analysis of chemical constituents, antimicrobial and anticancer activities of dichloromethane extracts of Sordariomycetes sp. endophytic fungi isolated from Strobilanthes crispus. · World journal of microbiology & biotechnology
29.PMID: 22471785 (2012) — In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell. · BMC complementary and alternative medicine
30.PMID: 20684795 (2010) — Anticancer activity of a sub-fraction of dichloromethane extract of Strobilanthes crispus on human breast and prostate cancer cells in vitro. · BMC complementary and alternative medicine