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PubMed · Volatile constituents of three <i>Thymus sipyleus</i> Boiss. subspecies from different sites in Turkey. (2021)
PubMed · In vitro effectiveness of Thymus sipyleus subsp. sipyleus var. sipyleus on Acanthamoeba castellanii and its cytotoxic potential on corneal cells. (2007)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 12 articles PubMed · modèle : gemma4:31b
Résumé
Turkish Thyme (Thymus sipyleus) is a medicinal plant from the Lamiaceae family used in folk medicine for various ailments, demonstrating antioxidant, antibacterial, and anti-inflammatory properties in vitro [PMID:38257392, 29908309, 31540139].
Contexte
Thymus sipyleus Boiss. is a species of the Lamiaceae family found wild in Turkey and the Greek islands of the North Aegean Region [PMID:38144604, 29875656]. It exists in several subspecies and varieties, including subsp. sipyleus var. sipyleus, subsp. sipyleus var. davisianus, and subsp. rosulans [PMID:38144604].
Usages traditionnels
In Turkish folk medicine, it is used for the treatment of rhinosinusitis [PMID:29908309] and skin wounds [PMID:31540139]. It is also used by locals in the Greek islands of the North Aegean Region to treat various ailments [PMID:29875656].
Composés actifs
Phytochemicals include kaempferol [PMID:38257392] and rosmarinic acid [PMID:36558163]. Volatile compounds vary by subspecies: subsp. sipyleus var. sipyleus contains 1,8-cineole, p-cymene, alpha-terpineol, and carvacrol [PMID:38144604]; subsp. sipyleus var. davisianus contains thymol (38.31%) and carvacrol (37.95%) [PMID:25385321], as well as geranial, neral, 1,8-cineole, beta-caryophyllene, and alpha-terpineol [PMID:38144604]; subsp. rosulans contains beta-caryophyllene, intermedeol, 1,8-cineole, alpha-terpineol, and alpha-pinene [PMID:38144604].
Mécanisme d'action
The herb demonstrates antioxidant activity via DPPH, ABTS, Fe3+-Fe2+ reducing, and CUPRAC assays [PMID:38257392, 36558163]. It exhibits tyrosinase inhibitory effects [PMID:36558163] and amoebicidal activity against Acanthamoeba castellanii trophozoites and cysts [PMID:17661186].
Preuves cliniques
Preuve DRhinosinusitis (In vitro)
Essential oil of T. sipyleus subsp. sipyleus var. sipyleus showed antimicrobial activity against associated strains including S. aureus, MRSA, S. epidermidis, S. pyogenes, S. pneumoniae, and P. aeruginosa [PMID:29908309]
Preuve DSkin Wounds (In vitro/Cellular)
Extracts of T. sipyleus subsp. rosulans showed proliferative activities, effects on wound closure, and hydroxyproline synthesis [PMID:31540139]
Preuve DAcanthamoeba castellanii (In vitro)
Methanolic extract showed remarkable amoebicidal activity against trophozoites and cysts [PMID:17661186]
Preuve DBacterial Biofilms (In vitro)
Essential oil of T. sipyleus subsp. sipyleus var. davisianus demonstrated anti-biofilm activity against Gram-positive and Gram-negative bacteria [PMID:25385321]
Preuve DSclerotinia sclerotiorum (In vitro)
Essential oils demonstrated antifungal potential against this soil-borne plant pathogen [PMID:41083786]
Sécurité et effets indésirables
In vitro tests on corneal cells were conducted to determine cytotoxicity of the methanolic extract [PMID:17661186], but specific adverse effect outcomes for humans are not detailed in the provided abstracts.
Synthèse des preuves
The current evidence is limited to in vitro, in silico, and ex vivo studies (Level D). There are no clinical trials or systematic reviews provided to support therapeutic efficacy in humans.
Sources PubMed
1.PMID: 38257392 (2024) — Phenolic Content Analysis of Two Species Belonging to the Lamiaceae Family: Antioxidant, Anticholinergic, and Antibacterial Activities. · Molecules (Basel, Switzerland)
2.PMID: 38144604 (2021) — Volatile constituents of three Thymus sipyleus Boiss. subspecies from different sites in Turkey. · Turkish journal of chemistry
3.PMID: 29908309 (2018) — Anti-inflammatory and antibacterial evaluation of Thymus sipyleus Boiss. subsp. sipyleus var. sipyleus essential oil against rhinosinusitis pathogens. · Microbial pathogenesis
4.PMID: 36558163 (2022) — New Biological and Chemical Evidences of Two Lamiaceae Species (Thymbra capitata and Thymus sipyleus subsp. rosulans): In Vitro, In Silico and Ex Vivo Approaches. · Molecules (Basel, Switzerland)
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— In vitro effectiveness of Thymus sipyleus subsp. sipyleus var. sipyleus on Acanthamoeba castellanii and its cytotoxic potential on corneal cells.
· Parasitology research
6.PMID: 31540139 (2019) — In Vitro Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial and Wound Healing Potential of Thymus Sipyleus Boiss. Subsp. Rosulans (Borbas) Jalas. · Molecules (Basel, Switzerland)
7.PMID: 25385321 (2015) — Chemical composition and anti-biofilm activity of Thymus sipyleus BOISS. subsp. sipyleus BOISS. var. davisianus RONNIGER essential oil. · Archives of pharmacal research
8.PMID: 29875656 (2018) — An Ethnobotanical Study of Medicinal Plants in the Greek Islands of North Aegean Region. · Frontiers in pharmacology
9.PMID: 26782294 (2016) — Bioanalytical LC/MS study of potential bacterial transglycosylation inhibitors. · Journal of pharmaceutical and biomedical analysis
10.PMID: 41083786 (2025) — Chemical profile and bioactivity of essential oils from five Turkish thyme species against white mold fungal disease agent Sclerotinia sclerotiorum. · Scientific reports
11.PMID: 22179264 (2012) — Repellent activities of some Labiatae plant essential oils against the saltmarsh mosquito Ochlerotatus caspius (Pallas, 1771) (Diptera: Culicidae). · Parasitology research
12.PMID: 22581297 (2012) — Acaricidal activity of the essential oils from three Lamiaceae plant species on Rhipicephalus turanicus Pom. (Acari: Ixodidae). · Parasitology research