Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Ya Nang work to reduce fever and detoxify the body?
Ya Nang (Tiliacora triandra) contains bioactive compounds including tetrandrine and cycleanine, which are bisbenzylisoquinoline alkaloids with demonstrated anti-inflammatory and antipyretic properties. These compounds work by modulating inflammatory pathways in the body. The flavonoids and chlorophyll content contribute antioxidant activity that supports the liver's natural detoxification processes. Traditional use suggests these compounds help eliminate toxins, though clinical evidence remains limited (Evidence Level C).
Does Ya Nang interact with any medications?
Limited research exists on Ya Nang drug interactions. Tetrandrine, a key active compound, affects calcium channels and may theoretically interact with calcium channel blockers, antiarrhythmic medications, and blood pressure drugs. Due to insufficient clinical data, individuals taking prescription medications should consult a healthcare provider before using concentrated Ya Nang preparations. Traditional culinary consumption in food amounts is generally considered low risk (Evidence Level C).
What is the recommended dosage of Ya Nang for adults?
The traditional adult dosage is 15-30 grams of fresh Ya Nang leaves prepared as juice or tea daily. This recommendation is based on Thai folk medicine tradition rather than standardized clinical trials (Evidence Level C, Traditional). Ya Nang leaves are commonly consumed as a vegetable in Southeast Asian cuisine, and culinary amounts are generally well tolerated. For therapeutic purposes, consult a qualified herbalist or healthcare provider for personalized guidance.
Is Ya Nang safe to take during pregnancy?
Ya Nang is not recommended during pregnancy, particularly in therapeutic or concentrated doses. Traditional knowledge and limited evidence indicate potential safety concerns for pregnant women (Evidence Level C). The active compounds, including tetrandrine, may pose risks to fetal development. Pregnant women should avoid Ya Nang supplements and consult a healthcare provider before consuming even culinary amounts. Women who are breastfeeding should also exercise caution and seek professional medical guidance.
Can Ya Nang help treat malaria and fever?
Ya Nang has a long history of traditional use in Thai folk medicine for treating fever and malaria. Laboratory studies suggest potential antiplasmodial activity against malaria parasites, attributed to compounds like tetrandrine and cycleanine (Evidence Level C). However, robust human clinical trials are lacking. Ya Nang should never replace conventional antimalarial treatment. It may serve as a complementary approach for fever management in traditional contexts, but proper medical diagnosis and treatment remain essential.
What are the side effects of consuming Ya Nang?
Ya Nang is generally well tolerated when consumed in traditional culinary amounts as a vegetable. No significant adverse effects have been widely documented in traditional use (Evidence Level C, Traditional). However, concentrated extracts or therapeutic doses may cause unknown effects due to limited clinical safety data. Individuals with known allergies to similar plants should exercise caution. Discontinue use and seek medical attention if any adverse reactions occur.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Tiliacora triandra, commonly known as Ya Nang, is a medicinal plant native to Southeast Asia with demonstrated antioxidant, anti-inflammatory, and neuroprotective properties [PMID:42125768, 34916822].
Contexte
Tiliacora triandra (Colebr.) Diels is a common vegetable consumed in Thailand and Laos [PMID:32281660]. It is also referred to as bamboo grass [PMID:30744355].
Usages traditionnels
It is traditionally used in Thailand as a revitalizing neurotonic agent [PMID:38107289] and to manage inflammatory and metabolic disorders [PMID:41901231].
Composés actifs
The plant contains bisbenzylisoquinoline alkaloids including magnoflorine, nortiliacorine A, tiliacorinin-2'-N-oxide, noryanangine, norisoyanangine [PMID:17265307], tiliacorinine [PMID:37813201], 2'-nortiliacorinine, and tiliacorine [PMID:22418278]. Other constituents include the flavonoid pectolinarigenin [PMID:41901231], 5,7-dihydroxy-6-oxoheptadecanoic acid (DHA) [PMID:32875596], epicatechin, quercetin [PMID:33669133], and polysaccharide gum (xylan) [PMID:35885245]. Leaf extracts are also rich in polyphenols [PMID:25371566].
Mécanisme d'action
In cancer cells, it induces apoptosis and inhibits growth signaling by up-regulating Ac-H3 and down-regulating p-ERK, p53, Bax, CDK4, and Bcl2 [PMID:36540797]. For diabetes, it inhibits hepatic glucose production by downregulating PEPCK and G6Pase while increasing phosphorylation of protein kinase B and AMP-activated protein kinase [PMID:33669133]. Neuroprotective effects are mediated via anti-neuroinflammation and modulation of oxidative stress markers such as MDA, SOD, CAT, and GSH [PMID:42125768, 32257892].
Preuves cliniques
Preuve DDiabetes (Animal Model)
Significantly decreased blood glucose levels, increased insulin secretion, and attenuated hyperlipidemia and organ complications [PMID:32281660, 33669133].
Preuve DCognitive Impairment/Memory Loss (Animal Model)
Enhanced spatial learning, memory, and learning flexibility in models of scopolamine-induced impairment, ethanol dependence, and cerebral ischemia/reperfusion [PMID:38107289, 30377596, 29062800, 26180599].
Preuve DCholangiocarcinoma (In Vitro/Xenograft)
Inhibited cell growth and induced apoptosis; showed synergistic effects when combined with Cisplatin or Gemcitabine [PMID:36540797, 37512080, 37813201].
Preuve DCisplatin-induced Toxicity (Animal Model)
Attenuated hepatorenal and testicular toxicity by modulating oxidative inflammation and apoptosis [PMID:35226987, 34916822].
Preuve DCholesterol Absorption (In Vitro)
Decreased the uptake of cholesterol by approximately 48% in Caco-2 cells [PMID:30312160].
Sécurité et effets indésirables
The safety of the leaf powder ethanolic extract (TLPE) was demonstrated in vitro via a hemolytic assay [PMID:37512080].
Interactions médicamenteuses
Tiliacora triandra leaf powder ethanolic extract (TLPE) exhibited synergistic drug interactions with Cisplatin and Gemcitabine, allowing for dose reduction of these chemotherapeutic agents [PMID:37512080].
Synthèse des preuves
The current evidence is based entirely on in vitro cell lines and animal models (rats, mice, cattle, chickens); there are no human clinical trials provided. Strength of evidence is low (Level D).
Sources PubMed
1.PMID: 32281660 (2020) — Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin-induced diabetes in rats. · Journal of food biochemistry
2.PMID: 38107289 (2023) — Neuroprotective effect of Tiliacora triandra (Colebr.) Diels leaf extract on scopolamine-induced memory impairment in rats. · Heliyon
3.PMID: 36540797 (2022) — Ethanolic extract of Ya-nang (Tiliacora triandra) leaf powder induces apoptosis in cholangiocarcinoma cell lines via induction of hyperacetylation and inhibition of growth signaling. · PeerJ
4.PMID: 30744355 (2019) — Effect of bamboo grass (Tiliacora triandra, Diels) pellet supplementation on rumen fermentation characteristics and methane production in Thai native beef cattle. · Asian-Australasian journal of animal sciences
5.PMID: 35266158 (2022) — Influence of bamboo grass (Tiliacora triandra, Diels) pellet supplementation on in vitro fermentation and methane mitigation.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 37512080 (2023) — Tiliacora triandra Leaf Powder Ethanolic Extract in Combination with Cisplatin or Gemcitabine Synergistically Inhibits the Growth of Cholangiocarcinoma Cells In Vitro and in Nude Mouse Xenograft Models. · Medicina (Kaunas, Lithuania)
7.PMID: 32257892 (2020) — Neuroprotective effects of Tiliacora triandra leaf extract in a mice model of cerebral ischemia reperfusion. · Avicenna journal of phytomedicine
8.PMID: 30377596 (2018) — Enhancing effect of Tiliacora triandra leaves extract on spatial learning, memory and learning flexibility as well as hippocampal choline acetyltransferase activity in mice. · Avicenna journal of phytomedicine
9.PMID: 29062800 (2017) — Tiliacora triandra (Colebr.) Diels leaf extract enhances spatial learning and learning flexibility, and prevents dentate gyrus neuronal damage induced by cerebral ischemia/reperfusion injury in mice. · Avicenna journal of phytomedicine
10.PMID: 35885245 (2022) — Structural and Rheological Properties of Yanang Gum (Tiliacora triandra). · Foods (Basel, Switzerland)
12.PMID: 32875596 (2021) — Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro-inflammatory responses in rats. · Journal of the science of food and agriculture
13.PMID: 33669133 (2021) — Tiliacora triandra (Colebr.) Diels Leaf Aqueous Extract Inhibits Hepatic Glucose Production in HepG2 Cells and Type 2 Diabetic Rats. · Molecules (Basel, Switzerland)
14.PMID: 35226987 (2022) — Tiliacora triandra attenuates cisplatin triggered hepatorenal and testicular toxicity in rats by modulating oxidative inflammation, apoptosis and endocrine deficit. · Frontiers in bioscience (Landmark edition)
15.PMID: 42125768 (2026) — Neuroprotective effects of Tiliacora triandra (Colebr.) Diels leaf extract against lipopolysaccharide-induced memory impairment via anti-neuroinflammation. · Biomedical reports
16.PMID: 37813201 (2023) — Induction of apoptotic cell death of cholangiocarcinoma cells by tiliacorinine from Tiliacora triandra: A mechanistic insight. · Biochimica et biophysica acta. General subjects
17.PMID: 25371566 (2014) — Bioactive compounds and encapsulation of Yanang (Tiliacora triandra) leaves. · African journal of traditional, complementary, and alternative medicines : AJTCAM
18.PMID: 33392866 (2021) — Milk production and composition efficiency as influenced by feeding Pennisetum purpureum cv. Mahasarakham with Tiliacora triandra, Diels pellet supplementation. · Tropical animal health and production
19.PMID: 30312160 (2018) — Inhibitory effects of Tiliacora triandra (Colebr.) Diels on cholesterol absorption. · Journal of complementary & integrative medicine
20.PMID: 34916822 (2021) — Antioxidant and Anti-inflammatory Properties Mediate the Neuroprotective Effects of Hydro-ethanolic Extract of Tiliacora triandra Against Cisplatin-induced Neurotoxicity. · Journal of inflammation research
21.PMID: 41829053 (2026) — Phytosynbiotic Containing Double-Layer Microencapsulated Pediococcus acidilactici V202 and Tiliacora triandra Leaf Extract Improve Growth Performance and Gut Health in Broiler Chickens. · Animals : an open access journal from MDPI
22.PMID: 41901231 (2026) — Pectolinarigenin from Tiliacora triandra Exhibits Potent Anticancer Activity in Triple-Negative Breast Cancer Cells Through Cell Cycle Arrest, Apoptosis, and MAPK Signaling Inhibition. · Pharmaceuticals (Basel, Switzerland)
23.PMID: 22418278 (2012) — Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis. · Bioorganic & medicinal chemistry letters
24.PMID: 3212079 (1988) — [Tilitriandrin: a new bisbenzylisoquinoline alkaloid from tiliacora triandra]. · Planta medica
25.PMID: 41150096 (2025) — In Vitro Three-Step Technique Assessment of a Microencapsulated Phytosynbiotic from Yanang (Tiliacora triandra) Leaf Extract Fermented with P. acidilactici V202 on Nutrient Digestibility, Cecal Fermentation, and Microbial Communities of Broilers. · Veterinary sciences
26.PMID: 25298673 (2014) — Effect of three fatty acids from the leaf extract of Tiliacora triandra on P-glycoprotein function in multidrug-resistant A549RT-eto cell line. · Pharmacognosy magazine
27.PMID: 26180599 (2015) — Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats. · Oxidative medicine and cellular longevity
28.PMID: 22619925 (2011) — Antimicrobial activity of the extracts from Benchalokawichian remedy and its components. · Journal of the Medical Association of Thailand = Chotmaihet thangphaet
29.PMID: 36765341 (2023) — In vitro antioxidant, anti-inflammatory, and anticancer activities of mixture Thai medicinal plants. · BMC complementary medicine and therapies
30.PMID: 39359905 (2024) — In Vitro Evaluation of α-Glucosidase and α-Amylase Inhibition in Thai Culinary Vegetables. · Scientifica