Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 4 articles PubMed · modèle : gemma4:31b
Résumé
Zao Jiao Ci (ZJC), the spine of Gleditsia sinensis, is a traditional Chinese medicine used for its anti-inflammatory and various other medicinal properties [PMID:27401288, PMID:27433183].
Contexte
Zao Jiao Ci (ZJC) is the spine of the Chinese Honey locust (Gleditsia sinensis Lam.) [PMID:27401288].
Usages traditionnels
In China, it has been traditionally used for anticancer, detoxication, detumescence, apocenosis, antiparasite effects, and to reduce inflammation [PMID:27401288, PMID:27433183].
Composés actifs
The herb contains bioactive phytochemicals, including soluble sugars and starch, though specific chemical constituents are mentioned as being reported in literature without being listed individually in the provided abstracts [PMID:37050082, PMID:27433183].
Mécanisme d'action
ZJC aqueous extract demonstrates anti-inflammatory effects by decreasing the expression of cyclooxygenase (COX)-2 and reducing the production of prostaglandin E2 (PGE2) and nitric oxide [PMID:27401288].
Preuves cliniques
Preuve DInflammation (Animal Model)
Aqueous extract of ZJC at 100mg/kg showed a significant suppressive effect on carrageenan-induced paw edema in rats [PMID:27401288].
Preuve DLaryngeal Squamous Cell Carcinoma (LSCC)
Network pharmacology and bioinformatics suggest ZJC is a promising candidate for treating LSCC, though molecular mechanisms are still being explored [PMID:34257654].
Synthèse des preuves
The current evidence is primarily based on in vitro studies, animal models, and bioinformatics analysis; there is a lack of human clinical trial data in the provided abstracts.
Sources PubMed
- 1.PMID: 37050082 (2023) — Comparative Transcriptome Analysis of Gleditsia sinensis Thorns at Different Stages of Development. · Plants (Basel, Switzerland)
- 2.PMID: 27401288 (2016) — In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action. · Journal of ethnopharmacology
- 3.PMID: 34257654 (2021) — Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC. · Journal of oncology
- 4.PMID: 27433183 (2016) — From Traditional Usage to Pharmacological Evidence: A Systematic Mini-Review of Spina Gleditsiae. · Evidence-based complementary and alternative medicine : eCAM