Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Garcinia cambogia's primary active compound, hydroxycitric acid (HCA), works by inhibiting the enzyme ATP-citrate lyase, which plays a key role in converting carbohydrates into fatty acids. This inhibition may reduce fatty acid synthesis and promote fat oxidation. Additionally, HCA may increase serotonin levels in the brain, potentially helping to suppress appetite and reduce food cravings. However, the clinical significance of these mechanisms for meaningful weight loss remains uncertain, with evidence level C suggesting inconsistent results in human trials.
Can I take Garcinia cambogia with diabetes medications?
Garcinia cambogia may interact with diabetes medications by affecting blood glucose levels. The supplement could potentially lower blood sugar, which may enhance the effects of antidiabetic drugs and cause hypoglycemia. Additionally, there are concerns about interactions with statin medications, as rare cases of hepatotoxicity have been reported. Individuals taking metformin, insulin, or other diabetes medications should consult a healthcare provider before using Garcinia cambogia, as dosage adjustments may be necessary.
What is the recommended dosage for Garcinia cambogia extract?
The typical adult dosage for Garcinia cambogia extract is 500-1500mg of hydroxycitric acid (HCA) taken before meals, usually two to three times daily. Most commercial supplements recommend doses at the lower end of this range. It is important to follow product-specific instructions and not exceed recommended amounts, as higher doses have not shown additional benefit and may increase the risk of adverse effects. Standardized extracts containing 50-60% HCA are commonly available.
Is Garcinia cambogia safe to take during pregnancy or breastfeeding?
Garcinia cambogia is considered unsafe during pregnancy and breastfeeding and should be avoided. There is insufficient safety data to support its use in pregnant or nursing individuals, and the potential risks to fetal and infant development are unknown. Additionally, rare cases of hepatotoxicity associated with Garcinia supplementation pose particular concerns during pregnancy when the liver is already under increased metabolic stress. Pregnant or breastfeeding individuals should not use this supplement.
Does Garcinia cambogia actually help with weight loss?
The evidence for Garcinia cambogia's effectiveness for weight loss is inconsistent and rated at level C. While some studies have shown modest reductions in body weight and fat accumulation, many clinical trials have found no significant difference compared to placebo. Any observed weight loss effects are typically small, often less than 1-2 kg over several weeks. The supplement remains widely marketed for weight management, but consumers should approach claims with realistic expectations and understand that results vary considerably.
What are the possible side effects of taking Garcinia cambogia?
Common side effects of Garcinia cambogia include headache, dry mouth, and digestive upset such as nausea, diarrhea, or abdominal discomfort. More serious but rare adverse effects include hepatotoxicity, which has prompted regulatory warnings in some countries. There have also been rare reports of mania in susceptible individuals, possibly related to serotonin effects. People with pre-existing liver disease should avoid this supplement entirely. Most side effects are mild and reversible upon discontinuation, but anyone experiencing severe symptoms should seek medical attention.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 28 articles PubMed · modèle : gemma4:31b
Résumé
Garcinia cambogia is a botanical supplement primarily used for weight loss [PMID:30000956], though it has been associated with significant hepatotoxicity [PMID:34400337, PMID:41262061].
Contexte
Garcinia gummi-gutta, also known as Garcinia cambogia, is a member of the Guttiferae family consisting of trees and shrubs found in tropical regions, including Asia and India [PMID:36785888].
Usages traditionnels
The fruit rind has been traditionally used in South India as a flavoring agent for fish curry and as a remedy for gastrointestinal problems, diarrhea, ulcers, bowel complaints, intestinal parasites, and rheumatism [PMID:36785888, PMID:25732350].
Composés actifs
The fruit rind contains hydroxycitric acid (HCA), a main organic acid component [PMID:30000956, PMID:25732350]. Seed oil contains five fatty acid methyl esters [PMID:26345007].
Mécanisme d'action
Hydroxycitric acid (HCA) inhibits ATP-dependent citrate lyase, which catalyzes the conversion of citrate to acetyl-CoA, thereby reducing de novo lipogenesis and increasing fat oxidation [PMID:25732350, PMID:22530711]. It may also regulate serotonin levels related to satiety [PMID:25732350]. In skeletal muscle, it may enhance glucose uptake by activating the Calcium/CaMKII/AMPK/GLUT4 pathway [PMID:35213784].
Preuves cliniques
Preuve AObesity/Weight Loss
A meta-analysis of 8 RCTs (530 subjects) found significant reductions in weight (-1.34 kg) and BMI (-0.99 kg/m2) [PMID:32951714]. However, other reviews note conflicting results and a lack of evidence for benefits beyond 12 weeks [PMID:22530711].
Preuve AGlycaemic Control
A systematic review and meta-analysis of 9 publications (444 participants) found that Garcinia cambogia has no significant effect on fasting blood sugar (FBS) or insulin [PMID:39943939].
Preuve BLUTS/BPH
A prospective randomized controlled study evaluated Garcinia extract (500 mg TID) alone or with Silodosin for lower urinary tract symptoms/benign prostatic hyperplasia [PMID:40209997].
Sécurité et effets indésirables
Garcinia is generally well tolerated in adults with occasional gastrointestinal discomfort [PMID:30000956]. However, it is strongly linked to herb-induced liver injury (HILI), including cases of acute liver failure, hepatocellular injury with jaundice, and death [PMID:34400337, PMID:29802521, PMID:41262061, PMID:35350509]. Over 200 adverse events of liver injury have been identified [PMID:41262061].
Grossesse et allaitement
There is no published experience regarding safety or efficacy in nursing mothers or infants; therefore, these products should probably be avoided, especially while nursing a newborn or preterm infant [PMID:30000956].
Interactions médicamenteuses
Long-term use of weight-loss supplements like Garcinia cambogia increases the risk of interactions with medications such as statins, warfarin, fluoxetine, and others [PMID:39770500].
Synthèse des preuves
Evidence for weight loss is conflicting, with some meta-analyses showing modest short-term efficacy while others suggest insufficient long-term data. There is strong clinical evidence (case reports and network data) linking the herb to severe hepatotoxicity.
Sources PubMed
1.PMID: 36479472 (2022) — Dietary supplements for obesity. · Journal of preventive medicine and hygiene
2.PMID: 30000956 (2006) — Garcinia cambogia attenuates adipogenesis by affecting CEBPB and SQSTM1/p62-mediated selective autophagic degradation of KLF3 through RPS6KA1 and STAT3 suppression. · Autophagy
3.PMID: 39136211 (2025) — Challenges in herbal-induced liver injury identification and prevention. · Liver international : official journal of the International Association for the Study of the Liver
4.PMID: 34307603 (2021) — Herb-induced liver injury: Systematic review and meta-analysis. · World journal of clinical cases
7.PMID: 26345007 (2015) — Evaluation and Characterization of Malabar Tamarind [Garcinia cambogia (Gaertn.) Desr.] Seed Oil. · Journal of food science and technology
8.PMID: 25732350 (2015) — A comprehensive scientific overview of Garcinia cambogia. · Fitoterapia
9.PMID: 35213784 (2022) — Garcinia Cambogia Improves High-Fat Diet-Induced Glucose Imbalance by Enhancing Calcium/CaMKII/AMPK/GLUT4-Mediated Glucose Uptake in Skeletal Muscle. · Molecular nutrition & food research
10.PMID: 32951714 (2020) — Effect of Garcinia cambogia supplement on obesity indices: A systematic review and dose-response meta-analysis. · Complementary therapies in medicine
11.PMID: 22530711 (2012) — Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. · Critical reviews in food science and nutrition
12.PMID: 34400337 (2022) — Garcinia cambogia, Either Alone or in Combination With Green Tea, Causes Moderate to Severe Liver Injury. · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
13.PMID: 26667686 (2015) — THE EFFECT OF GARCINIA CAMBOGIA AS COADJUVANT IN THE WEIGHT LOSS PROCESS. · Nutricion hospitalaria
14.PMID: 38528750 (2025) — Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective. · Journal of dietary supplements
15.PMID: 29802521 (2018) — Acute liver injury following Garcinia cambogia weight-loss supplementation: case series and literature review. · Internal and emergency medicine
16.PMID: 39220898 (2024) — Innovative treatments for obesity and NAFLD: A bibliometric study on antioxidants, herbs, phytochemicals, and natural compounds. · Heliyon
18.PMID: 40209997 (2025) — Evaluation of the Therapeutic Potential of Garcinia cambogia Alone or in Combination With Silodosin in the Management of LUTS/BPH: A Prospective Randomized Controlled Study. · Urology
19.PMID: 39943939 (2025) — The effects of Garcinia cambogia on glycaemic control and liver enzymes in adults: a systematic review and meta-analysis of randomised controlled trials. · Journal of nutritional science
20.PMID: 39808373 (2025) — Phytochemicals in Obesity Management: Mechanisms and Clinical Perspectives. · Current nutrition reports
21.PMID: 39770500 (2024) — Dietary Supplements for Weight Loss and Drug Interactions. · Pharmaceuticals (Basel, Switzerland)
22.PMID: 35223433 (2022) — Potential roles of Garcinia family as antimetabolic syndrome. · Journal of advanced pharmaceutical technology & research
23.PMID: 41262061 (2025) — Hepatotoxicity of dietary supplements containing Garcinia gummi-gutta (L.) N. Robson. · Pharmaceutical biology
24.PMID: 36237637 (2022) — Hypoglycemic and hypolipidemic effects of Garcinia cambogia extracts in streptozotocin-nicotinamide induced diabetic rat model. · International journal of clinical and experimental pathology