This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Mo Han Lian (Eclipta prostrata), also known as Bhringaraj, is a medicinal plant from the Asteraceae family used in traditional medicine for its anti-inflammatory, antioxidant, and antitumor properties [PMID:34827736, PMID:39047883].
Background
Eclipta prostrata (L.) L. (synonyms: Eclipta alba, Eclipta erecta) is an herbaceous plant found in tropical and subtropical regions [PMID:34827736, PMID:31116703]. It is widely utilized in Ayurvedic, traditional Chinese, and Unani systems of medicine [PMID:24191336].
Traditional uses
Traditional uses include treating skin diseases, liver and stomach disorders, infectious hepatitis, snake venom poisoning, gastritis, respiratory diseases (cough and asthma), hemorrhagic diseases (hemoptysis, hematemesis, hematuria, epistaxis, and uterine bleeding), coronary heart disease, hair loss, and vitiligo [PMID:34827736, PMID:28623383, PMID:31395303].
Active compounds
Active phytochemicals include coumestan derivatives (e.g., wedelolactone, demethylwedelolactone), phenolic acid derivatives, flavonoids (e.g., apigenin, luteolin, and sulfated flavonoids), triterpenoids, steroid saponins (e.g., Ecliptasaponin A), substituted thiophenes, alkaloids, and caffeoylquinic acid derivatives [PMID:34827736, PMID:30347918, PMID:39047883, PMID:39459257, PMID:3587518도, PMID:34840370].
Mechanism of action
Mechanisms include the induction of ferroptosis in multiple myeloma via the Keap1/Nrf2/HO-1 axis [PMID:38507850], inhibition of the HMGB1/TLR4/NF-κB pathway for myocardial protection [PMID:39047883], and inhibition of oxidative damage and ferroptosis via the HIF-1α/SLC7A11/GPX4 signaling pathway in ischemic stroke [PMID:40810078]. It also demonstrates PTP1B inhibitory effects related to anti-diabetes and anti-obesity activities [PMID:33361652].
Clinical evidence
Evidence DMultiple Myeloma
Ethanol extract induces ferroptosis in RPMI-8226 and U266 cells and shows in vivo anticancer effects in xenograft mouse models [PMID:38507850]
Evidence DAcute Myocardial Infarction
Ecliptasaponin A reduced myocardial infarction size and cardiomyocyte apoptosis in mouse models [PMID:39047883]
Evidence DIschemic Stroke
Wedelolactone exhibited neuroprotective effects, reducing brain infarct volume and swelling in MCAO/R and OGD/R models [PMID:40810078]
Evidence DAtopic Dermatitis
Ethanol extract improved symptoms and decreased epidermis/dermis thickness in HDM-induced mice models [PMID:35346812]
Evidence DOsteoporosis
Improved bone micro-structure in SAMP6 mice by inhibiting osteoclasts and modulating gut microbiota [PMID:30735116]
Evidence DHyperlipidemia
Ethanol extract fraction EPF3 demonstrated lipid-lowering activity in hyperlipidemic mice and hamsters [PMID:25562812]
Safety & adverse effects
In a study on hyperlipidemia, the LD50 of the active fraction EPF3 was undetectable as no mice died with administration of 10.4 g/kg [PMID:25562812].
Evidence summary
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant pharmacological potential in oncology, neurology, and inflammatory conditions, but lacks human clinical trial data.
PubMed sources
1.PMID: 38507850 (2024) — Ethanol extract of Eclipta prostrata induces multiple myeloma ferroptosis via Keap1/Nrf2/HO-1 axis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
2.PMID: 1440620 (1992) — Plants with a reputation against snakebite. · Toxicon : official journal of the International Society on Toxinology
3.PMID: 34827736 (2021) — Eclipta prostrata (L.) L. (Asteraceae): Ethnomedicinal Uses, Chemical Constituents, and Biological Activities. · Biomolecules
5.PMID: 30347918 (2018) — [Chemcial constituents of Eclipta prostrata].
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Ethanol extract and total alkaloids produced analgesic activity in albino mice models [PMID:15022160]
· Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
6.PMID: 39047883 (2024) — Ecliptasaponin A protects heart against acute ischemia-induced myocardial injury by inhibition of the HMGB1/TLR4/NF-κB pathway. · Journal of ethnopharmacology
7.PMID: 36970216 (2023) — Discovery of the radio-protecting effect of Ecliptae Herba, its constituents and targeting p53-mediated apoptosis in vitro and in vivo. · Acta pharmaceutica Sinica. B
8.PMID: 28623383 (2017) — Ethnopharmacological uses, phytochemistry, biological activities, and biotechnological applications of Eclipta prostrata. · Applied microbiology and biotechnology
9.PMID: 31395303 (2019) — A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) L. · Journal of ethnopharmacology
10.PMID: 31445129 (2019) — The role and mechanism of Asian medicinal plants in treating skin pigmentary disorders. · Journal of ethnopharmacology
11.PMID: 40810078 (2025) — Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling. · Drug design, development and therapy
12.PMID: 37959773 (2023) — Antioxidant and Antiproliferative Activities of Eclipta prostrata (L.) L. Extract and Isolated Compounds. · Molecules (Basel, Switzerland)
13.PMID: 24191336 (2013) — Accentuating the prodigious significance of Eclipta alba - an inestimable medicinal plant. · Pakistan journal of pharmaceutical sciences
14.PMID: 31917302 (2020) — New antibacterial thiophenes from Eclipta prostrata. · Fitoterapia
15.PMID: 41439000 (2025) — Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies. · Cancer innovation
16.PMID: 39459257 (2024) — Comprehensive Analysis of Sulfated Flavonoids in Eclipta prostrata for Quality Evaluation. · Molecules (Basel, Switzerland)
17.PMID: 31116703 (2019) — Phytochemistry and neuroprotective effects of Eclipta alba (L.) Hassk. · Journal of complementary & integrative medicine
18.PMID: 37242467 (2023) — Physical Properties and pH Environment of Foam Dressing Containing Eclipta prostrata Leaf Extract and Gelatin. · Pharmaceuticals (Basel, Switzerland)
19.PMID: 30735116 (2019) — Effects of Eclipta prostrata on gut microbiota of SAMP6 mice with osteoporosis. · Journal of medical microbiology
20.PMID: 25562812 (2015) — Effect of Eclipta prostrata on lipid metabolism in hyperlipidemic animals. · Experimental gerontology
21.PMID: 36836257 (2023) — Immunomodulatory Potency of Eclipta alba (Bhringaraj) Leaf Extract in Heteropneustes fossilis against Oomycete Pathogen, Aphanomyces invadans. · Journal of fungi (Basel, Switzerland)
22.PMID: 37928490 (2023) — Genome size estimation of false daisy, cheek weed, pot marigold and marigold. · Bioinformation
23.PMID: 35875188 (2022) — Biosynthetic studies through feeding experiments in Eclipta prostrata (L.) L. hairy roots. · Plant cell, tissue and organ culture
24.PMID: 35346812 (2022) — Anti-inflammatory effects of Eclipta prostrata Linné on house dust mite-induced atopic dermatitis in vivo and in vitro. · Journal of ethnopharmacology
25.PMID: 34840370 (2022) — Jasmonates promote enhanced production of bioactive caffeoylquinic acid derivative in Eclipta prostrata (L.) L. hairy roots. · Plant cell, tissue and organ culture
26.PMID: 39859974 (2024) — Anti-Inflammatory Potential and Synergic Activities of Eclipta prostrata (L.) L. Leaf-Derived Ointment Formulation in Combination with the Non-Steroidal Anti-Inflammatory Drug Diclofenac in Suppressing Atopic Dermatitis (AD). · Life (Basel, Switzerland)
27.PMID: 33361652 (2021) — PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from Eclipta prostrata L. · Biological & pharmaceutical bulletin
28.PMID: 38869195 (2024) — Bithiophene and coumestan derivatives from Eclipta prostrata (L.) L. and their hepatoprotective activity. · Journal of Asian natural products research
29.PMID: 15022160 (2004) — Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk. · Phytotherapy research : PTR
30.PMID: 33473502 (2016) — The complete chloroplast genome of Eclipta prostrata L. (Asteraceae). · Mitochondrial DNA. Part B, Resources