Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Mo Han Lian (Eclipta prostrata) works through its active compounds, particularly wedelolactone and ecliptine, which nourish Liver and Kidney Yin according to Traditional Chinese Medicine principles. In Ayurveda, it is classified as a rasayana (rejuvenative) herb for hair health. The herb contains antioxidants that may protect hair follicles from oxidative damage and support melanin production. It is traditionally used both internally and topically to darken hair, strengthen roots, and address premature graying (Evidence level: C, Traditional).
Does Eclipta prostrata interact with blood thinners?
Yes, Mo Han Lian may interact with anticoagulant and antiplatelet medications. The herb demonstrates anticoagulant properties and can potentiate the effects of blood-thinning drugs such as warfarin, aspirin, clopidogrel, and heparin. This interaction may increase bleeding risk. Patients taking anticoagulant medications should consult a qualified healthcare provider before using this herb. Discontinue use at least two weeks before any scheduled surgery. Evidence level: C (theoretical interaction based on pharmacological activity).
What is the recommended dosage for Mo Han Lian?
The typical adult dosage for Mo Han Lian is 9-15 grams of dried herb daily when prepared as a decoction. For standardized extracts, 500mg to 1 gram taken twice daily is commonly recommended. For hair-related concerns, the herb can be applied topically as an infused oil. Dosage should be adjusted based on individual constitution and the specific condition being addressed. Consult a qualified herbalist or healthcare practitioner for personalized dosing recommendations (Evidence level: C, Traditional).
Is Mo Han Lian safe during pregnancy?
No, Mo Han Lian (Eclipta prostrata) is considered unsafe during pregnancy. Traditional Chinese Medicine contraindicates this herb for pregnant women due to its effects on blood and potential uterine stimulation. The herb has been traditionally used to address bleeding disorders, suggesting it may affect clotting mechanisms critical during pregnancy. Breastfeeding women should also avoid this herb due to insufficient safety data. Always consult a qualified healthcare provider before using any herbal supplement during pregnancy or lactation.
Can Mo Han Lian help with liver problems?
Mo Han Lian has been used traditionally in both TCM and Ayurveda as a hepatoprotective herb. Active compounds including wedelolactone and oleanolic acid have demonstrated liver-protective properties in preliminary research. The herb is traditionally indicated for Liver Yin deficiency patterns in TCM. However, clinical evidence remains limited (Evidence level: C), and Mo Han Lian should not replace conventional medical treatment for liver conditions. Individuals with liver disease should work with a qualified healthcare provider for appropriate diagnosis and treatment.
What are the side effects of Eclipta prostrata?
Mo Han Lian is generally well-tolerated when used appropriately, but may cause mild digestive effects including nausea or loose stools in some individuals. The herb is contraindicated in conditions of cold and deficiency with diarrhea, as it may worsen these symptoms. Due to its anticoagulant properties, it may cause increased bleeding or bruising, particularly in those with bleeding disorders or taking blood-thinning medications. Discontinue use if adverse effects occur and consult a healthcare provider.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Mo Han Lian (Eclipta prostrata), also known as Bhringaraj, is a medicinal plant from the Asteraceae family used in traditional medicine for its anti-inflammatory, antioxidant, and antitumor properties [PMID:34827736, PMID:39047883].
Contexte
Eclipta prostrata (L.) L. (synonyms: Eclipta alba, Eclipta erecta) is an herbaceous plant found in tropical and subtropical regions [PMID:34827736, PMID:31116703]. It is widely utilized in Ayurvedic, traditional Chinese, and Unani systems of medicine [PMID:24191336].
Usages traditionnels
Traditional uses include treating skin diseases, liver and stomach disorders, infectious hepatitis, snake venom poisoning, gastritis, respiratory diseases (cough and asthma), hemorrhagic diseases (hemoptysis, hematemesis, hematuria, epistaxis, and uterine bleeding), coronary heart disease, hair loss, and vitiligo [PMID:34827736, PMID:28623383, PMID:31395303].
Composés actifs
Active phytochemicals include coumestan derivatives (e.g., wedelolactone, demethylwedelolactone), phenolic acid derivatives, flavonoids (e.g., apigenin, luteolin, and sulfated flavonoids), triterpenoids, steroid saponins (e.g., Ecliptasaponin A), substituted thiophenes, alkaloids, and caffeoylquinic acid derivatives [PMID:34827736, PMID:30347918, PMID:39047883, PMID:39459257, PMID:3587518도, PMID:34840370].
Mécanisme d'action
Mechanisms include the induction of ferroptosis in multiple myeloma via the Keap1/Nrf2/HO-1 axis [PMID:38507850], inhibition of the HMGB1/TLR4/NF-κB pathway for myocardial protection [PMID:39047883], and inhibition of oxidative damage and ferroptosis via the HIF-1α/SLC7A11/GPX4 signaling pathway in ischemic stroke [PMID:40810078]. It also demonstrates PTP1B inhibitory effects related to anti-diabetes and anti-obesity activities [PMID:33361652].
Preuves cliniques
Preuve DMultiple Myeloma
Ethanol extract induces ferroptosis in RPMI-8226 and U266 cells and shows in vivo anticancer effects in xenograft mouse models [PMID:38507850]
Preuve DAcute Myocardial Infarction
Ecliptasaponin A reduced myocardial infarction size and cardiomyocyte apoptosis in mouse models [PMID:39047883]
Preuve DIschemic Stroke
Wedelolactone exhibited neuroprotective effects, reducing brain infarct volume and swelling in MCAO/R and OGD/R models [PMID:40810078]
Preuve DAtopic Dermatitis
Ethanol extract improved symptoms and decreased epidermis/dermis thickness in HDM-induced mice models [PMID:35346812]
Preuve DOsteoporosis
Improved bone micro-structure in SAMP6 mice by inhibiting osteoclasts and modulating gut microbiota [PMID:30735116]
Preuve DHyperlipidemia
Ethanol extract fraction EPF3 demonstrated lipid-lowering activity in hyperlipidemic mice and hamsters [PMID:25562812]
Sécurité et effets indésirables
In a study on hyperlipidemia, the LD50 of the active fraction EPF3 was undetectable as no mice died with administration of 10.4 g/kg [PMID:25562812].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant pharmacological potential in oncology, neurology, and inflammatory conditions, but lacks human clinical trial data.
Sources PubMed
1.PMID: 38507850 (2024) — Ethanol extract of Eclipta prostrata induces multiple myeloma ferroptosis via Keap1/Nrf2/HO-1 axis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
2.PMID: 1440620 (1992) — Plants with a reputation against snakebite. · Toxicon : official journal of the International Society on Toxinology
3.PMID: 34827736 (2021) — Eclipta prostrata (L.) L. (Asteraceae): Ethnomedicinal Uses, Chemical Constituents, and Biological Activities. · Biomolecules
5.PMID: 30347918 (2018) — [Chemcial constituents of Eclipta prostrata]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Ethanol extract and total alkaloids produced analgesic activity in albino mice models [PMID:15022160]
6.PMID: 39047883 (2024) — Ecliptasaponin A protects heart against acute ischemia-induced myocardial injury by inhibition of the HMGB1/TLR4/NF-κB pathway. · Journal of ethnopharmacology
7.PMID: 36970216 (2023) — Discovery of the radio-protecting effect of Ecliptae Herba, its constituents and targeting p53-mediated apoptosis in vitro and in vivo. · Acta pharmaceutica Sinica. B
8.PMID: 28623383 (2017) — Ethnopharmacological uses, phytochemistry, biological activities, and biotechnological applications of Eclipta prostrata. · Applied microbiology and biotechnology
9.PMID: 31395303 (2019) — A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) L. · Journal of ethnopharmacology
10.PMID: 31445129 (2019) — The role and mechanism of Asian medicinal plants in treating skin pigmentary disorders. · Journal of ethnopharmacology
11.PMID: 40810078 (2025) — Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling. · Drug design, development and therapy
12.PMID: 37959773 (2023) — Antioxidant and Antiproliferative Activities of Eclipta prostrata (L.) L. Extract and Isolated Compounds. · Molecules (Basel, Switzerland)
13.PMID: 24191336 (2013) — Accentuating the prodigious significance of Eclipta alba - an inestimable medicinal plant. · Pakistan journal of pharmaceutical sciences
14.PMID: 31917302 (2020) — New antibacterial thiophenes from Eclipta prostrata. · Fitoterapia
15.PMID: 41439000 (2025) — Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies. · Cancer innovation
16.PMID: 39459257 (2024) — Comprehensive Analysis of Sulfated Flavonoids in Eclipta prostrata for Quality Evaluation. · Molecules (Basel, Switzerland)
17.PMID: 31116703 (2019) — Phytochemistry and neuroprotective effects of Eclipta alba (L.) Hassk. · Journal of complementary & integrative medicine
18.PMID: 37242467 (2023) — Physical Properties and pH Environment of Foam Dressing Containing Eclipta prostrata Leaf Extract and Gelatin. · Pharmaceuticals (Basel, Switzerland)
19.PMID: 30735116 (2019) — Effects of Eclipta prostrata on gut microbiota of SAMP6 mice with osteoporosis. · Journal of medical microbiology
20.PMID: 25562812 (2015) — Effect of Eclipta prostrata on lipid metabolism in hyperlipidemic animals. · Experimental gerontology
21.PMID: 36836257 (2023) — Immunomodulatory Potency of Eclipta alba (Bhringaraj) Leaf Extract in Heteropneustes fossilis against Oomycete Pathogen, Aphanomyces invadans. · Journal of fungi (Basel, Switzerland)
22.PMID: 37928490 (2023) — Genome size estimation of false daisy, cheek weed, pot marigold and marigold. · Bioinformation
23.PMID: 35875188 (2022) — Biosynthetic studies through feeding experiments in Eclipta prostrata (L.) L. hairy roots. · Plant cell, tissue and organ culture
24.PMID: 35346812 (2022) — Anti-inflammatory effects of Eclipta prostrata Linné on house dust mite-induced atopic dermatitis in vivo and in vitro. · Journal of ethnopharmacology
25.PMID: 34840370 (2022) — Jasmonates promote enhanced production of bioactive caffeoylquinic acid derivative in Eclipta prostrata (L.) L. hairy roots. · Plant cell, tissue and organ culture
26.PMID: 39859974 (2024) — Anti-Inflammatory Potential and Synergic Activities of Eclipta prostrata (L.) L. Leaf-Derived Ointment Formulation in Combination with the Non-Steroidal Anti-Inflammatory Drug Diclofenac in Suppressing Atopic Dermatitis (AD). · Life (Basel, Switzerland)
27.PMID: 33361652 (2021) — PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from Eclipta prostrata L. · Biological & pharmaceutical bulletin
28.PMID: 38869195 (2024) — Bithiophene and coumestan derivatives from Eclipta prostrata (L.) L. and their hepatoprotective activity. · Journal of Asian natural products research
29.PMID: 15022160 (2004) — Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk. · Phytotherapy research : PTR
30.PMID: 33473502 (2016) — The complete chloroplast genome of Eclipta prostrata L. (Asteraceae). · Mitochondrial DNA. Part B, Resources