PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Faster resolution of the inflammation phase and increased production of granulation tissue [PMID:31145533].
Decreased ulcer surface area compared to controls [PMID:31145533].
Oral administration of 2g capsules daily for two weeks improved wound status scores compared to placebo [PMID:36632430].
A combination of Calendula and Echinacea angustifolia was found more effective than breastmilk, though overall high-quality evidence is limited [PMID:30000917].
Evaluated as a cortisone-free topical agent for preventing severe acute radiation dermatitis in head and neck cancer patients [PMID:40480289].
Safety & adverse effects
Pregnancy & lactation
Evidence summary
PubMed sources
- 1.PMID: 31145533 (2019) — A systematic review of Calendula officinalis extract for wound healing. · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
- 2.PMID: 30000917 (2006) — An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L. · Pharmaceuticals (Basel, Switzerland)
- 3.PMID: 41404424 (2025) — Hydrogel-Wrapped Calendula officinalis L. extracellular vesicles - A novel approach to enhance fracture healing by Macrophage reprogramming. · Materials today. Bio
- 4.PMID: 36770999 (2023) — Catechol-O-methyltransferase Inhibitors from Calendula officinalis Leaf. · Molecules (Basel, Switzerland)
- 5.PMID: 39771213 (2024)