Question 1

How does Vitex negundo work as an anti-inflammatory?

Accepted Answer

Vitex negundo contains active compounds including luteolin, iridoid glycosides, vitexin, and flavonoids that exert anti-inflammatory effects. These compounds inhibit pro-inflammatory mediators and cytokines in the body. The flavonoids, particularly luteolin, have demonstrated COX-2 inhibitory activity, while iridoid glycosides contribute analgesic properties. This mechanism supports its traditional use for joint inflammation and respiratory conditions (Evidence Level B).

Question 2

Can I take Vitex negundo with birth control pills?

Accepted Answer

Vitex negundo may reduce the effectiveness of hormonal contraceptives due to its hormone-regulating properties. Women taking oral contraceptives, hormone replacement therapy, or other hormonal medications should consult a healthcare provider before using this herb. Additionally, Vitex negundo may interact with medications metabolized by the liver. Always disclose all supplements to your healthcare provider to avoid potential interactions (Evidence Level B).

Question 3

What is the recommended dosage for Vitex negundo?

Accepted Answer

The standard adult dosage for Vitex negundo is 3-6 grams of dried leaf prepared as a decoction, taken up to three times daily. Alternatively, standardized extracts of approximately 300mg can be taken three times daily. Dosage may vary based on the specific preparation and condition being treated. Always follow product label instructions or consult a qualified herbalist for personalized dosing (Evidence Level B, Traditional).

Question 4

Is Vitex negundo safe to take during pregnancy?

Accepted Answer

Vitex negundo is contraindicated during pregnancy and should be avoided. The herb has hormonal regulatory properties that may stimulate uterine contractions and potentially affect fetal development. Traditional use and available evidence indicate it is unsafe for pregnant women. Women who are pregnant, planning to become pregnant, or breastfeeding should not use Vitex negundo without explicit guidance from a qualified healthcare provider (Evidence Level B).

Question 5

What is Vitex negundo (Lagundi) used for?

Accepted Answer

Vitex negundo, known as Lagundi in Filipino traditional medicine, is primarily used for respiratory disorders including cough, bronchitis, and asthma. It also serves as an anti-inflammatory agent for joint inflammation and arthritis. Additionally, the herb functions as a uterine tonic for menstrual regulation. Its therapeutic applications stem from anti-inflammatory, analgesic, and bronchodilatory properties recognized in Asian traditional medicine systems (Evidence Level B, Traditional).

Question 6

What are the side effects of taking Vitex negundo?

Accepted Answer

Vitex negundo is generally well-tolerated at recommended doses. Reported side effects are typically mild and may include gastrointestinal disturbances such as nausea, stomach discomfort, or diarrhea. Some individuals may experience headaches. These effects are usually transient and resolve with continued use or dose adjustment. Discontinue use if adverse reactions persist or worsen, and consult a healthcare provider (Evidence Level B).

Vitex Negundo

Sources & Citations

Shatavari Tonic

Black Cohosh

Vitex

Summary

Background

Traditional uses

Active compounds

Mechanism of action

Clinical evidence

Evidence summary

PubMed sources

Government sources