Bhumyamalaki (Phyllanthus amarus): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Bhumyamalaki protect the liver?

Bhumyamalaki contains active compounds including phyllanthin, hypophyllanthin, corilagin, and ellagic acid that demonstrate hepatoprotective activity. These compounds work through antioxidant mechanisms, reducing oxidative stress on liver cells, and may inhibit viral replication. Research suggests phyllanthin helps stabilize liver cell membranes while geraniin provides anti-inflammatory effects. Traditional Ayurvedic use spans centuries for liver ailments, though clinical evidence remains limited (Evidence Level C).

Does Bhumyamalaki interact with blood thinners like warfarin?

Yes, Bhumyamalaki may interact with anticoagulant medications. The herb possesses blood-thinning properties that could enhance the effects of warfarin, aspirin, clopidogrel, and other anticoagulants, potentially increasing bleeding risk. Patients taking blood thinners should avoid Bhumyamalaki or consult a healthcare provider before use. This interaction is based on pharmacological properties rather than extensive clinical studies (Evidence Level C). Always disclose all supplements to your prescribing physician.

What is the recommended dosage of Bhumyamalaki for adults?

Traditional adult dosages include 3-5 grams of dried herb prepared as tea daily, or 500 mg of standardized extract taken three times daily. For liver support, the extract form may offer more consistent potency of active compounds like phyllanthin. Dosage should be adjusted based on individual health status and should not exceed recommended amounts without professional guidance. Long-term safety data is limited, so periodic breaks from use are advisable (Evidence Level: Traditional/C).

Is Bhumyamalaki safe to take during pregnancy?

No, Bhumyamalaki is contraindicated during pregnancy. Traditional Ayurvedic texts and modern safety assessments classify this herb as unsafe for pregnant women. The herb may stimulate uterine contractions and pose risks to fetal development. Women who are pregnant, planning pregnancy, or breastfeeding should avoid Bhumyamalaki entirely. Consult a qualified healthcare provider for safe alternatives for liver support during pregnancy.

Is Bhumyamalaki effective for treating Hepatitis B?

Bhumyamalaki has been studied for Hepatitis B with some promising preliminary findings. Research suggests the herb may inhibit hepatitis B virus replication and support liver enzyme normalization in some patients. However, clinical evidence remains limited (Evidence Level C), and Bhumyamalaki should not replace conventional antiviral treatments. In Ayurvedic medicine, it has been traditionally used for jaundice and hepatitis for centuries. Patients with Hepatitis B should work with a qualified healthcare provider rather than self-treating.

Can Bhumyamalaki help with kidney stones?

Bhumyamalaki has traditional use for kidney stones and urinary tract health. The herb is closely related to Phyllanthus niruri (chanca piedra), commonly called 'stone breaker' in South American traditional medicine. Traditional use suggests it may help prevent calcium oxalate stone formation and support urinary tract function. However, clinical evidence specifically for Bhumyamalaki in kidney stone treatment is limited (Evidence Level: Traditional). Adequate hydration remains the primary recommendation for kidney stone prevention.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Bhumyamalaki (Phyllanthus amarus) is a medicinal herb used in traditional Ayurvedic medicine, primarily recognized for its hepatoprotective, antiviral, and anti-inflammatory properties [PMID:38642916, PMID:40901185, PMID:40271556].

Contexte

Phyllanthus amarus is a small herb from the Euphorbiaceae family, globally distributed and central to the Indian Ayurvedic system of medicine [PMID:21982793, PMID:36407559]. In India, several species of the Phyllanthus genus are referred to as 'Bhumyamalaki' [PMID:22408311].

Usages traditionnels

It is traditionally used for the prevention and treatment of jaundice and various liver disorders [PMID:38642916, PMID:22408311]. Other traditional applications include treating problems of the stomach, kidney, spleen, and genitourinary system, as well as conditions such as gonorrhea, menorrhagia, diarrhea, dysentery, intermittent fevers, scabies, and wounds [PMID:21982793].

Composés actifs

The herb contains a diversity of bioactive compounds including lignans (such as phyllanthin and hypophyllanthin), flavonoids (such as quercetin), alkaloids, terpenoids, tannins (including ellagitannins), polyphenols, sterols, and phenolic derivatives [PMID:38642916, PMID:21982793, PMID:23594304].

Mécanisme d'action

Anti-inflammatory effects are facilitated by reducing pro-inflammatory cytokine production and inhibiting the synthesis of prostaglandins and nitric oxide [PMID:40271556]. In cancer models, it has been shown to induce the expression of p53 and p45NFE2, inhibit DNA topoisomerase II, and inhibit the cell cycle regulatory enzyme cdc25 tyrosine phosphatase [PMID:19815595, PMID:12020923]. It also demonstrates acetylcholinesterase inhibitory potential [PMID:36046175].

Preuves cliniques

Preuve DDiabetic Neuropathy

Bhumyamalaki Churna (3g twice daily) combined with Atibala was studied in 33 patients to assess sensory perception and symptoms like numbness and pain [PMID:22529650].

Preuve DDiabetic Nephropathy

As part of an Ayurvedic formulation including Gokshuradi Guggulu and Vasa, it contributed to a significant reduction in serum creatinine, blood urea, and urinary albumin excretion in patients [PMID:22131758].

Preuve DHepatotoxicity (Animal Models)

Leaf extracts restored deranged biochemical parameters in rat models of CCl4 and rifampicin-induced hepatic and renal assault [PMID:33364479].

Preuve DErythroleukemia (Animal Model)

Oral administration decreased the progression of FMuLv-induced erythroleukemia and enhanced the life span of mice [PMID:19815595].

Preuve DCardiac Function (Animal Model)

Leaf extracts mitigated the increase of ACE, arginase, AChE, ADA, and LDH activities and MDA levels in doxorubicin-stressed rats [PMID:31823659].

Synthèse des preuves

The evidence is primarily based on review articles, in vitro studies, and animal models (Level C and D), with limited clinical data from small-scale Ayurvedic studies. High-level evidence (RCTs/Meta-analyses) for specific clinical conditions is lacking in the provided set.

Sources PubMed

1.PMID: 38642916 (2025) — Phytochemical profile and hepatoprotective potentiality of Phyllanthus genus: a review. · The Journal of pharmacy and pharmacology
2.PMID: 22529650 (2011) — Effect of Atibalamula and Bhumyamalaki on thirty-three patients of diabetic neuropathy. · Ayu
3.PMID: 22408311 (2011) — Pharmacognostic evaluation of leaves of certain Phyllanthus species used as a botanical source of Bhumyamalaki in Ayurveda. · Ayu
4.PMID: 38315581 (2025) — Identification of authentic Phyllanthus amarus species in India. · Natural product research
5.PMID: 31823659 (2022) — Modulatory effects of stonebreaker (Phyllanthus amarus) and bitter gourd (Momordica charantia) on enzymes linked with cardiac function in heart tissue of doxorubicin-stressed rats. · Drug and chemical toxicology

Bhumyamalaki

Sources et citations

Calculer une dose sûre de Bhumyamalaki

Strobilanthes Crispus

Indian Kalonji Seed

Kayu Manis Jamu

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Bhumyamalaki

Sources et citations

Calculer une dose sûre de Bhumyamalaki

Plantes associées

Strobilanthes Crispus

Indian Kalonji Seed

Kayu Manis Jamu

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Synthèse des preuves

Sources PubMed

Sources gouvernementales