Clerodendrum serratum (Clerodendrum serratum): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Clerodendrum serratum work for asthma?

Clerodendrum serratum contains active compounds including clerodendrin, flavonoids, and iridoid glycosides that exhibit bronchodilatory and anti-inflammatory properties. These compounds are believed to help relax bronchial smooth muscles and reduce airway inflammation, which may alleviate asthma symptoms and improve breathing. The herb also demonstrates antipyretic effects for fever reduction. Evidence level: C (preliminary research and traditional use).

Is Clerodendrum serratum safe to take during pregnancy?

No, Clerodendrum serratum is considered unsafe during pregnancy and should be avoided. Traditional Ayurvedic texts contraindicate its use in pregnant women, and there is insufficient safety data to support use during pregnancy or breastfeeding. Women who are pregnant, planning to become pregnant, or breastfeeding should not use this herb. Evidence level: C (traditional contraindication).

What is the recommended dosage for Clerodendrum serratum?

The traditional Ayurvedic dosage for Clerodendrum serratum is 3-6 grams of root or leaf prepared as a decoction, typically taken once or twice daily. To prepare, boil the plant material in water, strain, and consume. Dosage may vary based on the specific condition and individual factors. Consult a qualified Ayurvedic practitioner or healthcare provider for personalized guidance. Evidence level: Traditional.

Does Clerodendrum serratum interact with any medications?

Limited clinical data exists on specific drug interactions for Clerodendrum serratum. Due to its bronchodilatory and anti-inflammatory effects, caution is advised when combining with prescription bronchodilators, corticosteroids, or other asthma medications, as the herb may theoretically potentiate or interfere with these drugs. Patients taking respiratory or anti-rheumatic medications should consult a healthcare provider before use. Evidence level: C.

What is Clerodendrum serratum used for in Ayurveda?

Clerodendrum serratum, known as Bharangi in Ayurveda, is traditionally used for respiratory conditions including asthma, bronchitis, and chronic cough. It is also employed for fever reduction, rheumatic conditions, and as an anti-inflammatory agent. The herb has been used in Ayurvedic medicine for centuries to support respiratory health and manage inflammatory conditions. Evidence level: C (traditional use with preliminary research).

What are the side effects of Clerodendrum serratum?

Clerodendrum serratum may cause mild gastrointestinal upset in some individuals, including nausea or stomach discomfort. No serious adverse effects have been commonly reported at traditional dosages. However, individuals with severe asthma should seek medical advice before use, as this herb should not replace prescribed asthma treatments. Discontinue use if adverse reactions occur. Evidence level: C (traditional use reports).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 20 articles PubMed · modèle : gemma4:31b

Résumé

Clerodendrum serratum is a medicinal plant found in tropical and warm temperate regions, traditionally used for treating inflammation, respiratory disorders, and pain [PMID:24727551].

Contexte

Clerodendrum serratum (L.) Moon, also known as Bharangi or Cheruthekku, is a member of the Verbenaceae family distributed across Africa, Southern Asia, Malaysia, India, and Sri Lanka [PMID:24727551].

Usages traditionnels

It is traditionally valued in India for treating pain, inflammation, rheumatism, respiratory disorders, fever, and malarial fever [PMID:24727551]. It is also recognized as an anti-allergic drug in Asian folk medicine [PMID:38143476].

Composés actifs

Identified compounds include bharangin [PMID:19168424], ursolic acid [PMID:17585689], and flavonoids such as apigenin and luteolin [PMID:28458420]. Other constituents include diterpenes and terpenoid glucosides [PMID:31368375, PMID:11265600].

Mécanisme d'action

The plant may attenuate the production of inflammatory mediators (including IL-4, IL-5, IL-1β, TNF-α, and LTD-4) in asthma models [PMID:38143476]. It has demonstrated anti-biofilm potency against Mycobacterium species [PMID:40812437] and inhibits the production of nitric oxide (NO) in L929 and RAW 264.7 cells [PMID:42064586].

Preuves cliniques

Preuve BChronic Sinusitis (Kaphaja Shirsha Shoola)

Used as one of nine ingredients in the traditional Sri Lankan decoction Pitawakka Navaya to treat chronic sinusitis [PMID:22131709].

Preuve DAllergic Asthma

Ethanolic root extract attenuated inflammatory mediators and biomarkers in ovalbumin-induced rat models [PMID:38143476].

Preuve DArthritis/Inflammation

Standardized aqueous extracts demonstrated anti-inflammatory and anti-arthritic potential [PMID:33912046].

Preuve DHepatotoxicity

Ursolic acid isolated from roots showed significant hepatoprotective activity against carbon tetrachloride-induced toxicity in rats [PMID:17585689].

Preuve DDepressive-like behavior

Leaf extract (specifically flavonoids apigenin and luteolin) showed neuroprotective effects against acute restraint stress-induced symptoms in mice [PMID:28458420].

Preuve DMycobacterial Infections

Sécurité et effets indésirables

An acute oral toxicity study was conducted to evaluate the biosafety of the plant and its phytoconstituents [PMID:31368375].

Synthèse des preuves

The evidence is primarily based on preclinical animal models (rats, mice), in vitro studies, and virtual screenings, with limited clinical trial data involving polyherbal formulations. Most findings are categorized as level D (preclinical/other).

Sources PubMed

1.PMID: 24727551 (2014) — Clerodendrum serratum (L.) Moon. - a review on traditional uses, phytochemistry and pharmacological activities. · Journal of ethnopharmacology
2.PMID: 38143476 (2022) — Clerodendrum serratum extract attenuates production of inflammatory mediators in ovalbumin-induced asthma in rats. · Turkish journal of chemistry
3.PMID: 40812437 (2025) — Mechanistic evaluation of Clerodendrum serratum anti-biofilm potency against Mycobacterium species. · Microbial pathogenesis
4.PMID: 23284214 (2012) — Anti-histaminic, mast cell stabilizing and bronchodilator effect of hydroalcoholic extract of polyherbal compound- Bharangyadi. · Ancient science of life
5.PMID: 22131709 (2010) — A clinical trial of Sri Lankan traditional decoction of Pitawakka Navaya in treatment of Kaphaja Shirsha Shoola (chronic sinusitis).

Clerodendrum serratum

Sources et citations

Calculer une dose sûre de Clerodendrum serratum

Prunus avium

Alpinia calcarata

Enterolobium cyclocarpum

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Clerodendrum serratum

Sources et citations

Calculer une dose sûre de Clerodendrum serratum

Plantes associées

Prunus avium

Alpinia calcarata

Enterolobium cyclocarpum

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales