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PubMed · Mechanisms, Machinery, and Dynamics of Chromosome Segregation in <i>Zea mays</i>. (2024)
PubMed · By-Products of Zea mays L.: A Promising Source of Medicinal Properties with Phytochemistry and Pharmacological Activities: A Comprehensive Review. (2023)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Corn silk (Zea mays), the styles and stigmas of maize, is a traditional medicinal herb with reported antioxidant, anti-inflammatory, and metabolic regulatory effects [PMID:40437199, PMID:38398644].
Contexte
Corn silk consists of the hair-like stigmata of female maize flowers [PMID:37361240]. It is an agricultural byproduct of Zea mays L., a global cereal crop [PMID:42227415, PMID:40461278].
Usages traditionnels
Corn silk is used as a traditional medicine in many nations, including China, the United States, Turkey, and France [PMID:37187994, PMID:22890173]. It has been traditionally used by the Chinese and Native Americans to treat various diseases, and is used in teas and supplements for urinary-related problems [PMID:22890173].
Composés actifs
Bioactive constituents include flavonoids (such as quercetin, rutin, and apigenin), polysaccharides (specifically corn silk polysaccharide or CSP), polyphenols, sterols (such as beta-sitosterol), terpenoids, saponins, phenolic acids, fatty acids, and organic acids [PMID:37361240, PMID:40437199, PMID:42227415, PMID:38398644].
Mécanisme d'action
Corn silk may exert its effects through several signaling pathways, including the down-regulation of the PI3K/AKT/NF-κB pathway to reduce inflammation and apoptosis in hyperuricemia [PMID:37294890], and the PI3K/Akt pathway for anti-cancer effects [PMID:37361240]. Other involved pathways include Nrf2 and FoxO1 [PMID:42227415]. In the liver, acidic polysaccharides (CSP-50E) may function through the caspase cascade and mitochondrial apoptosis pathway [PMID:36863670].
Preuves cliniques
Preuve ADyslipidemia/Angina Pectoris
A meta-analysis of four RCTs indicated that corn silk decoction is effective in improving the lipid profile in patients with angina pectoris [PMID:31423665].
Preuve BDiabetes/Hyperglycemia
Preliminary clinical trials show promise for anti-diabetic effects, though larger RCTs are needed [PMID:40437199].
Preuve DHyperuricemia
Corn silk flavonoids exhibited uric acid-lowering activity in vitro and in vivo by inhibiting xanthine oxidase (XOD) and promoting uric acid excretion [PMID:37294890].
Preuve DHepatoprotection
Acidic polysaccharides from corn silk (CSP-50E) showed significant hepatoprotective effects in vitro by reducing IL-6, TNF-α, AST, and ALT activity in ethanol-induced damaged liver cells [PMID:36863670].
Sécurité et effets indésirables
Corn silk is noted for having fewer adverse reactions compared to conventional anti-hyperglycemic drugs [PMID:37187994]. However, comprehensive safety and effectiveness evaluations are still being reviewed [PMID:36721262].
Synthèse des preuves
The evidence for corn silk is primarily based on preclinical in vitro/in vivo studies and reviews (Level C/D), with one systematic review/meta-analysis (Level A) supporting its use for lipid profiles in angina pectoris and preliminary clinical data (Level B) for diabetes.
Sources PubMed
1.PMID: 37294890 (2023) — Corn Silk Flavonoids Ameliorate Hyperuricemia via PI3K/AKT/NF-κB Pathway. · Journal of agricultural and food chemistry
2.PMID: 37187994 (2023) — Bioactive compounds of corn silk and their role in management of glycaemic response. · Journal of food science and technology
4.PMID: 40461278 (2026) — Field Preparation and Planting Corn (Zea mays). · Cold Spring Harbor protocols
5.PMID: 22890173 (2012) — Corn silk (Stigma maydis) in healthcare: a phytochemical and pharmacological review.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 37361240 (2023) — Anti-cancerous effect of corn silk: a critical review on its mechanism of action and safety evaluation. · 3 Biotech
7.PMID: 42227415 (2026) — Corn Silk in Pharmaceutical Biotechnology: Bioactive Compounds, Pharmacological Activities, and Mechanistic Insights. · Current pharmaceutical biotechnology
8.PMID: 36721262 (2023) — By-Products of Zea mays L.: A Promising Source of Medicinal Properties with Phytochemistry and Pharmacological Activities: A Comprehensive Review. · Chemistry & biodiversity
9.PMID: 31423665 (2019) — Corn silk decoction for blood lipid in patients with angina pectoris: A systematic review and meta-analysis. · Phytotherapy research : PTR
10.PMID: 36863670 (2023) — Acidic polysaccharide from corn silk: Structural & conformational properties and hepatoprotective activity. · International journal of biological macromolecules
11.PMID: 38398644 (2024) — An Umbrella Insight into the Phytochemistry Features and Biological Activities of Corn Silk: A Narrative Review. · Molecules (Basel, Switzerland)